Myasthenia gravis and Guillain-Barré cooccurrence syndrome

Zhang, Juan; Niu, Shiqin; Wang, Yan; Hu, Wenli

doi:10.1016/j.ajem.2013.05.029

Cited by 9 publications

(12 citation statements)

References 14 publications

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“…3 To the best of our knowledge, the occurrence of MG and GBS overlap syndrome is quite rare. [3][4][5][6][7][8][9][10][11][12][13][14] Furthermore, only 4 studies have reported the comorbidity of MG and MFS previously. [15][16][17][18] Here, we review all previously described cases and present a new case of our own.…”

mentioning

confidence: 99%

The clinical features of patients concurrent with Guillain-Barré syndrome and myasthenia gravis

Yuan

Zhang

et al. 2018

NSJ

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confidence: 99%

The clinical features of patients concurrent with Guillain-Barré syndrome and myasthenia gravis

Yuan

Zhang

et al. 2018

NSJ

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“…It is also noted that this combination of disorders are more prevalent between Chinese people which may in part point to the possible genetic background and ethnicity as predisposing factors for this rare combination [4,5]. In this report, we have presented a case of MG, newly diagnosed during her severe exacerbation, with clues for GBS particularly facial palsy that lead to the diagnosis of GBS after several days of ICU admission.…”

Section: Introductionmentioning

confidence: 83%

Co-occurrence of Guillain-Barré syndrome and myasthenia gravis, the first report in Iran

Rismanchi¹,

Rismanchi²,

Karimian³

2020

Ann Musculoskelet Med

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Guillain-Barré syndrome and myasthenia gravis are two immune mediated neuromuscular diseases, both threaten respiratory function and may emerge as medical emergencies. Co-occurrence of the two entities though possible is a rare condition, and therefore poses special diagnostic diffi culties. Herein, a report of co-presentation of Guillain-Barré syndrome and myasthenia gravis is discussed and the literature is studied regarding this rare combination. Case Study

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“…Both diseases have different pathophysiology and the nature of the presentation. The appearance of both in the same individual is a rare entity and is often under-recognised [1]. So far, only 14 reports have been reported in which 15 cases have been diagnosed with the coexistence of MG and GBS.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Guillain-Barré syndrome and Myasthenia Gravis in an elderly male

Karri

Ramasamy

Perumal

2019

Egypt J Neurol Psychiatry Neurosurg

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Introduction: The occurrence of both Guillain-Barré syndrome(GBS) and myasthenia gravis (MG) in the same individual is rare. The underlying pathophysiology was assumed to be autoimmune humoral mechanisms and molecular mimicry with a cross-reaction between autoantibodies and myelin sheath of peripheral nerves and acetylcholine receptors of the neuromuscular junction (NMJ). Case description: A 68-year-old male known diabetic and hypertensive with good drug compliance presented with acute onset quadriparesis with bulbar involvement for 1 day. On examination, he had mild neck flexion weakness and bulbar weakness. He had flaccid quadriparesis with absent deep tendon reflexes and negative Babinski. The rest of the neurological examination was normal. Discussion and evaluation: Blood and electrophysiological studies showed evidence of demyelinating polyradiculoneuropathy with temporal dispersion suggestive of Guillain-Barré syndrome. He was treated with intravenous immunoglobin and complete resolution of symptoms. Two months later, he presented with new-onset asymmetrical ptosis and bulbar symptoms for 3 days. On further evaluation, repetitive nerve stimulation showed postsynaptic neuromuscular disorder pattern typical of myasthenia gravis, which was further confirmed by positive acetylcholinesterase receptor antibodies (AChR). Thymoma was ruled out by imaging. He was treated with anticholinesterases, low dose steroids, and immunosuppressants (azathioprine) following which he had improvement of symptoms. Conclusion: Our patient, who was initially diagnosed with Guillain-Barré syndrome and recovered, presented 2 months later with a new-onset illness suggestive of myasthenia gravis. This existence of two different neurological entities in the same individual is a rarity, and early recognition is essential for treatment decision and prognostic strategies.

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Myasthenia gravis and Guillain-Barré cooccurrence syndrome

Cited by 9 publications

References 14 publications

The clinical features of patients concurrent with Guillain-Barré syndrome and myasthenia gravis

The clinical features of patients concurrent with Guillain-Barré syndrome and myasthenia gravis

Co-occurrence of Guillain-Barré syndrome and myasthenia gravis, the first report in Iran

Occurrence of Guillain-Barré syndrome and Myasthenia Gravis in an elderly male

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