Myasthenia Gravis as a Paraneoplastic Syndrome Associated With Renal Cell Carcinoma

Torgerson, Erik; Khalili, Ramin; Dobkin, Bruce H.; Reiter, Robert E.

doi:10.1097/00005392-199907000-00037

Cited by 17 publications

(11 citation statements)

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“…In the patient with renal cell carcinoma (Table 1 no. 4), the first evidence for metastatic disease coincided with the diagnosis of MG, similar to another case report [11]. Our patient with chordoma (no.…”

Section: Discussionsupporting

confidence: 90%

Extrathymic malignancies in patients with myasthenia gravis

Levin

Abramsky

Lossos

et al. 2005

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 90%

Extrathymic malignancies in patients with myasthenia gravis

Levin

Abramsky

Lossos

et al. 2005

Journal of the Neurological Sciences

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“…Onconeural antibodies occur only in a small proportion of patients with cancer who develop peripheral neuropathy [7]. Previous case reports of paraneoplastic neuropathies associated with RCC have also described negative antibody screens preceding RCC diagnosis [2, 6, 15, 16, 17, 18–20]. Likewise, our patient was seronegative for common paraneoplastic antibodies including anti-Hu, anti-Ma, and anti-CV2 [21].…”

Section: Discussion and Review Of The Literaturesupporting

confidence: 53%

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

2017

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Neurologic symptoms secondary to a paraneoplastic syndrome may be the presenting manifestation of a previously undiagnosed cancer, and alertness to these syndromes may provide an opportunity for early detection and treatment of a cancer. Paraneoplastic weakness is a rare manifestation of renal cell carcinoma and may present with variable electrophysiological features. We present a case of a patient with progressive weakness, sensory changes, and urinary retention, with electrophysiological features suggestive of a complex peripheral nervous system syndrome. Ultimately, a renal cell mass was detected and resected, resulting in significant clinical improvement. We review the literature, cataloging the known neurologic syndromes and antibodies associated with renal cell carcinoma. This case highlights that paraneoplastic neurological disorders associated with RCC can take on many features and provides a resource to practitioners for early detection of a neurologic paraneoplastic syndrome arising from renal cell carcinoma.

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“…Most paraneoplastic syndromes associated with RCC remit after resection of the primary RCC or treatment of metastatic sites. Several clinical syndromes have been reported as paraneoplastic manifestations of RCC, among this group there is a variety of neurological paraneoplastic syndromes (table 1) [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Opsoclonus-Myoclonus Syndrome as a Paraneoplastic Manifestation of Renal Cell Carcinoma

et al. 2002

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Opsoclonus is a rare but distinctive disorder of ocular motility, characterized by irregular, continual and conjugated chaotic saccades of the eyes. It is increased with eye closure and fixation, and it persists during sleep. Opsoclonus appears more commonly in children and in half of such cases in association with neuroblastoma. In adults the most frequent causes are idiopathic (50%) and paraneoplastic (20%). Among the second group, different types of tumors involving a wide variety of organs have been reported. Opsoclonus when accompanied by other symptoms of central nervous system involvement (head, appendicular myoclonus and truncal ataxia) constitutes a clinical picture, known as opsoclonus-myoclonus syndrome. We report the case of a young patient affected by renal cell carcinoma associated with opsoclonus-myoclonus syndrome which did not respond to medical therapy but dramatically improved after cancer ablation.

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Myasthenia Gravis as a Paraneoplastic Syndrome Associated With Renal Cell Carcinoma

Cited by 17 publications

References 1 publication

Extrathymic malignancies in patients with myasthenia gravis

Extrathymic malignancies in patients with myasthenia gravis

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

Opsoclonus-Myoclonus Syndrome as a Paraneoplastic Manifestation of Renal Cell Carcinoma

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