Myasthenia gravis: long-term prognostic value of thymus lactate dehydrogenase isoenzyme pattern of hyperplastic thymus and thymoma.

Szathmáry, I; Selmeci, L.; Posch, E.; Szobor, A; Molnár, J.

doi:10.1136/jnnp.48.8.757

Cited by 1 publication

(1 citation statement)

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“…Very limited information is available about the diagnostic or prognostic role of circulating LDH in thymoma. Of note, there was one study in a myasthenia gravis patient cohort, where LDH isoenzyme levels were measured in the homogenized thymus tissue [ 37 ]. Nevertheless, similar to earlier studies analyzing overall survival in Asian patients we could confirm the inferior–in our study disease specific - survival of thymic carcinoma patients with increased LDH levels also in a Caucasian patient cohort [ 17 , 18 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Prognostic Value of Preoperative Leukocyte Count, Lactate Dehydrogenase and C-Reactive Protein in Thymic Epithelial Tumors

Valdivia

Cheufou

Fels

et al. 2021

Pathol. Oncol. Res.

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Thymic epithelial tumors are the most common mediastinal tumors. Surgery is the mainstay of treatment and complete resection provides the best survival rate. However, advanced tumors often require multimodality treatment and thus we analyzed the prognostic potential of routine circulating biomarkers that might help to risk-stratify patients beyond tumor stage and histology. Preoperative values for white blood cell count (WBC), C-reactive protein (CRP) and lactate dehydrogenase (LDH) were analyzed in 220 thymic epithelial tumor patients operated between 1999 and 2018. Increased CRP levels (>1 mg/dl) were significantly more often measured in thymic carcinoma and neuroendocrine tumors when compared to thymoma. LDH serum activity was higher in thymic neuroendocrine tumors when compared to thymoma or thymic carcinoma. The median disease specific survival was significantly longer in thymoma cases than in thymic carcinoma and neuroendocrine tumors. Increased preoperative LDH level (>240 U/L) associated with shorter survival in thymus carcinoma (HR 4.76, p = 0.0299). In summary, higher CRP associated with carcinoma and neuroendocrine tumors, while LDH increased primarily in neuroendocrine tumors suggesting that biomarker analysis should be performed in a histology specific manner. Importantly, preoperative serum LDH might be a prognosticator in thymic carcinoma and may help to risk stratify surgically treated patients in multimodal treatment regimens.

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