Myasthenia Gravis Related to Thymic Carcinoma: A Case Study

Lopes, Daniel Thomas Pereira; Gomes, Samila Marissa Pinheiro; Siqueira, Sheila Aparecida Coelho; Frassetto, Fernando Pereira; P, Sampaio; Moreno, Cristiane Araújo Martins; Rocha, M. S.; Estephan, Eduardo de Paula

doi:10.1055/s-0040-1714075

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…One of the most common paraneoplastic disease associated with thymic abnormalities is MG. About 70-80% of patients with MG have thymic hyperplasia or thymoma but, even rare, few cases of thymus carcinoma have been reported (16,17). MG is a heterogeneous neuromuscular disease caused by an autoimmune mediated response against post synaptic nicotinic acetylcholine receptors (AChRs) preventing their activation at the neuromuscular junction.…”

Section: Mgmentioning

confidence: 99%

Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies

Minervini¹,

Boschetti²,

Gregor³

et al. 2021

Gland Surg

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Objective: This study aimed to provide an extensive overview of clinical and pathological findings along with various therapeutic options analyzing in addiction, retrospectively, the surgical outcomes of a single center cohort.Background: Thymic neoplasms are rare thoracic tumors which commonly are located in the anterior mediastinum and are associated with a wide spectrum of clinical presentations. They may run an indolent course or could present a very aggressive biologic progression with infiltration of mediastinal structures and presence of distant metastases. The pathogenesis of these tumors is so far not completely clear. Several treatment modalities in a multidisciplinary setting have to be considered in order to provide the best treatment for patients affected by thymic tumors. Methods:We conducted a retrospective cohort analysis of all patients who underwent surgery due to thymic tumor in a university hospital located in Switzerland (Bern University Hospital) and then we performed a narrative review of the English literature using PubMed, Embase, Cochrane Database of Systematic Reviews and Scopus.Conclusions: Minimally invasive techniques play an important role in the treatment of thymic tumors. A careful patients selection in a multidisciplinary setting is mandatory in order to offer the best treatment for patients affected by thymic tumors.

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Section: Mgmentioning

confidence: 99%

Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies

Minervini¹,

Boschetti²,

Gregor³

et al. 2021

Gland Surg

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“…This is a common combination. Up until now, there has been no connection between thymic carcinoma and myasthenia gravis (8) .…”

Section: Introductionmentioning

confidence: 99%

Survival Outcomes and Prognostic Factors of Thymic Epithelial Tumors a Single Center Experience

2024

The Egyptian Journal of Hospital Medicine

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Background: Thymic epithelial tumors (TET) constitute the most common neoplasia in the anterior mediastinum, although they account for less than 1% of all neoplasms. Objective: This is a retrospective study conducted to analyze clinic-epidemiological characteristics, prognostic factors, treatment modality and survival outcomes of patients with thymic epithelial tumors. Patients and Methods: All patients diagnosed with Thymic epithelial tumors (TETs) over a period of 10 years (from 2010 to 2019) were reviewed. A clinical sheet was designed for 34 cases, and all clinicopathological data were collected. Data analysis was performed using both the Kaplan-Meier method and Cox proportional hazards modeling. Results: seventy-six (76%) of patients presented with thymoma (N: 26) while only 8 patients had thymic carcinoma. By Masoaka staging system 35.3% of the patients were stage III. Myasthenia gravis presented in 11 patients (32.4%). Multiple treatment modalities were needed for 22 patients (64.7%) while single modality was used in 12 patients (35.3 %). Twenty-three of the patients (67.6%) underwent surgical resection. Twenty-nine (29%) of the patients received adjuvant RT. Conclusion:For patients with TETs, surgery is statistically significant for Overall survival (OAS) prognostic factors and the Masoaka staging system is the only statistically significant factor of the progression-free survival (PFS) prognostic factors.

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“…Not by chance, most patients with MG have thymic abnormalities, with more than 50% of anti-AChR positive cases having thymic hyperplasia and 10% to 15% thymic tumor, usually thymoma 3 . Carcinoma has also been rarely reported in association with the disease 4 .…”

Section: Introductionmentioning

confidence: 99%

Myasthenia gravis in clinical practice

Estephan

Baima

Zambon

2022

Arq. Neuro-Psiquiatr.

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Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease. Objective: this review aims to summarize the main practical aspects of the diagnostic approach, treatment and care of myasthenic patients. Methods: The authors performed a non-systematic critical review summarizing the main practical aspects of myasthenia gravis. Results: Most patients with myasthenia have autoantibodies targeted at acetylcholine receptors or, less commonly, muscle-specific kinase - MuSK. Electrophysiology plays an important role in the diagnosis of neuromuscular junction dysfunction. The central clinical manifestation of myasthenia gravis is fatigable muscle weakness, which can affect eye, bulbar, respiratory, and limb muscles. With rare exceptions, patients have a good response to symptomatic treatment, but corticosteroids and/or immunosuppressants are usually also necessary to obtain good control of the manifestations of the disease. Conclusion: Knowledge of the peculiar aspects of their clinical and electrophysiological presentations is important for the diagnosis. Likewise, specific treatment and response time to each drug are crucial for proper care.

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Myasthenia Gravis Related to Thymic Carcinoma: A Case Study

Cited by 3 publications

References 14 publications

Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies

Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies

Survival Outcomes and Prognostic Factors of Thymic Epithelial Tumors a Single Center Experience

Myasthenia gravis in clinical practice

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