Myasthenia gravis with cutaneous polyarteritis nodosa

Sayed, F. El; Dhaybi, Rola Al; Ammoury, Alfred; Chababi, Myrna; Bazex, J

doi:10.1111/j.1365-2230.2005.02015.x

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…None had aimed to investigate the MG autoantibodies. They had mainly described clinical observations like a paraneoplastic MG with central nervous system lymphoma (12), an association of MG with polyarteritis nodosa (13), and a thymoma accompanied by MG, PRCA, and Good's syndrome (14). Other discussed management of MG like the radiotherapy for thymoma resection (15), the safety of cardiopulmonary bypass 123 and gender, MGFA Class, MG category, thymus status, history of respiratory crisis, choice of treatment, and response to treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Lebanese studies about MG were very rare and limited to few case reports. These works had only presented some clinical observations and operational methods to manage MG without investigating Correspondence autoantibodies (12)(13)(14)(15). Therefore, the present study aimed at determining the prevalence of different autoantibodies and their association with clinical phenotypes and quality of life (QOL) in a Lebanese group with MG.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Autoantibodies, clinical phenotypes and quality of life in Lebanese patients with myasthenia gravis

Baalbaki,

Agha,

Jaafar

et al. 2023

IRDR

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Myasthenia gravis (MG) is a rare autoimmune disease that affects the neuromuscular junction. It is characterized by the production of heterogeneous autoantibodies that bind to the neuromuscular junction and alter neural transmission. Recently, more attention was given to MG-related antibodies and their clinical influence. In Lebanon, studies about MG are very rare. To date, there is still no research on the different autoantibodies developed by Lebanese MG patients. We conducted a study aimed at detecting the prevalence of different antibodies in a group of seventeen Lebanese patients with MG, and exploring their associations with clinical phenotypes and quality of life (QOL). MG antibody test in Lebanon is restricted only to two antibodies: acetylcholine receptor (anti-AChR) and muscle-specific kinase (anti-MUSK) antibodies. Results showed that 70.6% of patients were anti-AChR positive and all of them were anti-MUSK negative. Association between MG serological profiles, clinical outcomes and QOL was not significant. Together, current findings suggest that anti-MUSK antibody is not common and difference in antibody profile may not change the clinical phenotypes and QOL of MG Lebanese patients. In the future, it is recommended to check also for autoantibodies other than anti-AChR and anti-MUSK, which may reveal new antibody profiles and possible associations with clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Autoantibodies, clinical phenotypes and quality of life in Lebanese patients with myasthenia gravis

Baalbaki,

Agha,

Jaafar

et al. 2023

IRDR

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“…While some cases of MG have been associated with vascular pathology, to the best of our knowledge no cases of spontaneous iliopsoas hematoma associated with myasthenic crisis have been reported in the literature [6]. MG has an incidence of 0.21 -2 per 100,000, and while bulbar symptoms including dysphagia, slurred speech, and weakness are the hallmark of the disease, associations with coagulopathy or major bleeding is not well documented [7].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Retroperitoneal Hematoma in the Setting of Myasthenic Crisis

Galgano

Bernshteyn

Kaul

2020

Cureus

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Our case highlights a patient with spontaneous retroperitoneal hematoma without clear cause in the setting of myasthenic crisis. While myasthenia gravis (MG) has been reported in the literature to be associated with vascular pathology such as polyarteritis nodosa, its association with coagulopathy and spontaneous major bleed is currently unclear. The patient in this case developed a sudden unprovoked iliopsoas hematoma while in the ICU for the management of newly diagnosed MG. Acute anemia was the only clinical sign which was later confirmed by imaging findings.

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“…In a more recently published study by Liozon et al [10], only one case of MG is reported in a series of 250 patients with GCA during a study period of 27 years. We also found one case report describing the concurrence of MG with polyarteritis nodosa [11], as well as a case of myasthenia gravis in the setting of microscopic polyangiitis [12]. …”

Section: Discussionmentioning

confidence: 99%

Myasthenia Gravis and Stroke in the Setting of Giant Cell Arteritis

Tripodaki

Kakavas

Skrapari

et al. 2013

Case Reports in Rheumatology

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This case report concerns the diagnosis of two independent chronic diseases in a patient hospitalized for stroke, myasthenia gravis (MG) and giant cell arteritis (GCA). MG has been found to be associated with several diseases, but there are very few cases documenting its coexistence with GCA. We report the case of a 79-year-old woman initially hospitalized for stroke. Patient's concurrent symptoms of blepharoptosis, dysphagia, and proximal muscle weakness were strongly suggestive of myasthenia gravis. The persistent low-grade fever and elevated inflammatory markers in combination with the visual deterioration that developed also raised the suspicion of GCA. Histological examination confirmed GCA, while muscle acetylcholine receptor antibodies were also present. Even though in medicine one strives to interpret a patient's symptoms with one diagnosis, when one entity cannot fully interpret the clinical and laboratory findings, clinicians must consider the possibility of a second coexisting illness.

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Myasthenia gravis with cutaneous polyarteritis nodosa

Cited by 9 publications

References 6 publications

Autoantibodies, clinical phenotypes and quality of life in Lebanese patients with myasthenia gravis

Autoantibodies, clinical phenotypes and quality of life in Lebanese patients with myasthenia gravis

Spontaneous Retroperitoneal Hematoma in the Setting of Myasthenic Crisis

Myasthenia Gravis and Stroke in the Setting of Giant Cell Arteritis

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