MYB, CD117 and SOX‐10 expression in cutaneous adnexal tumors

Evangelista, Mara Therese P.; North, Jeffrey P.

doi:10.1111/cup.12904

Cited by 23 publications

(23 citation statements)

References 11 publications

(18 reference statements)

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“…Benign adnexal tumors usually show a characteristic pattern of MYB expression in a cluster pattern in the central portion of the tumor aggregations. The successive loss of nuclear MYB expression is interpreted as a hint for malignant transformation 36. Evangelista et al recently confirmed the results of previous studies, showing homogeneous MYB positive clusters only in cylindromas and spiradenomas 30,32,36.…”

mentioning

confidence: 72%

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

et al. 2018

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confidence: 72%

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

et al. 2018

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“…Our case adds to this list, and ancillary immunohistochemical marker studies performed out of academic interest highlight potential pitfalls with basaloid-appearing breast neoplasms. Recent investigations of MYB and SOX-10 expression in cutaneous adnexal tumors have shown 85% (17/20) immunohistochemical reactivity for both MYB and SOX-10 in cylindromas with SOX-10 studies showing more diffuse and intense staining patterns [ 35 ]. While SOX-10 is known to play an important role in melanocyte development and can be used as a diagnostic marker of malignant melanoma, this protein is less studied in tumors of the apocrine and eccrine sweat glands.…”

Section: Discussionmentioning

confidence: 99%

“…While SOX-10 is known to play an important role in melanocyte development and can be used as a diagnostic marker of malignant melanoma, this protein is less studied in tumors of the apocrine and eccrine sweat glands. Diffuse expression in cylindromas can be considered as a marker of myoepithelial differentiation [ 35 ]. While malignant transformation of cutaneous cylindromas is rare, reports of some cases do exist [ 36 ].…”

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confidence: 99%

Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm

Halima

Pannunzio

Erstine

et al. 2018

Case Reports in Pathology

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Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. In rare instances, solitary cylindromas may arise at other body sites. In the current case, a cylindroma of the skin of the breast was diagnosed by complete excision. Immunohistochemical studies confirmed the tumor cells to be immunoreactive with cytokeratin AE1/3, cytokeratin 5/6, cytokeratin 7, p63, and SOX10. The neoplastic cells were also noted to be immunoreactive with markers typically expected to be positive in ductal epithelium of the breast including GATA3, mammaglobin, and E-cadherin. The case emphasizes the importance of correlating clinical setting, imaging studies, patient history, and careful microscopic evaluation in arriving at an accurate diagnosis. This case also illustrates the point that not all “breast” tumors that are confirmed to be positive for GATA3, mammaglobin, and E-cadherin are derived from mammary ducts.

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“…Regarding cutaneous adnexal tumors, in 2017 Evangelista and North reported SOX10 positivity in spiradenomas, cylindromas and mixed tumors, presumably because of myoepithelial differentiation commonly present in all of them; also they emphasized that SOX10 and CD117 appear to be important proteins for apocrine and eccrine sweat units. In the same study, all follicular tumors included were negative for SOX10 . Finally, SOX10 can be expressed in cutaneous myoepitheliomas …”

Section: Introductionmentioning

confidence: 89%

SOX10 Immunostaining in granulomatous dermatoses and benign reactive lymph nodes

et al. 2019

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Background: SOX10 immunostaining has been considered a highly sensitive and specific marker for melanoma. But there is evidence suggesting that SOX10 positive cells can be present in dermal scars. Therefore, we investigated whether non-melanocytic cell types present in chronic inflammatory processes or benign lymph nodes express SOX10. Methods:We retrospectively selected 20 benign lymph nodes and 20 cutaneous granulomatous dermatoses. SOX10, CD68, and Melan-A immunohistochemistry was performed in all cases.Results: Scattered SOX10 positivity was found in 85% of lymph nodes, specifically in subcapsular and medullary sinuses and in 85% of granulomatous dermatoses. In granulomatous dermatoses, the Melan-A stain did not label the scattered SOX10 positive cells and it was difficult to determine if CD68 was co-expressed on the SOX10 positive cells.In the lymph nodes, the SOX10 positive cells did not co-express Melan-A or CD68. Conclusions:We report SOX10 positive cells detected in granulomatous dermatoses and benign lymph nodes. In lymph nodes, SOX10 positive cells were exclusively in subcapsular and medullary sinuses. Therefore, SOX10 is an excellent stain for evaluation of metastatic melanoma with the caveat that positivity in subcapsular and medullary sinuses can be of non-melanocytic origin; the use of additional melanocytic markers is recommended in this situations. K E Y W O R D Sbenign lymph nodes, granulomatous dermatoses, immunohistochemistry, SOX10

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MYB, CD117 and SOX‐10 expression in cutaneous adnexal tumors

Abstract: Expression of MYB appears limited to a small number of cutaneous adnexal tumors, including cylindromas, spiradenomas, ACCs, mucinous carcinoma, endocrine mucin-producing sweat gland carcinoma and some cases of EMPD.

Cited by 23 publications

References 11 publications

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm

SOX10 Immunostaining in granulomatous dermatoses and benign reactive lymph nodes

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