MYB transcription factors in Arabidopsis

Dubos, Christian; Stracke, Ralf; Grotewold, Erich; Weißhaar, Bernd; Martin, Cathie; Lepiniec, Loïc

doi:10.1016/j.tplants.2010.06.005

Cited by 3,288 publications

(2,923 citation statements)

References 111 publications

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“…Based on the number of MYB domain, the MYB family can be divided into four classes, 1R-, R2R3-, 3R-and 4R-MYB proteins (Dubos et al 2010;Stracke et al 2001). R2R3-MYB proteins are specific to plants and are also the most abundant type in plants, with more than 100 R2R3-MYB members in the genomes of dicots and monocots (Jiang et al 2004a;Wilkins et al 2009).…”

Section: Structure Of Mybmentioning

confidence: 99%

“…MYB genes were generated by successive gain of repeat units. Du et al (2009) and Dubos et al (2010) have reviewed the structure, characteristic, classification, multi-functionality, mechanism of combinational control, the "gain" model for evolution and function redundancy of MYB genes in detail.…”

Section: Evolution Of Mybmentioning

confidence: 99%

“…A tremendous amount of data is available on the roles of MYB transcription factors in plants (Du et al 2009;Dubos et al 2010). The functions of MYB proteins have been investigated in numerous plant species such as Arabidopsis, maize, cotton, rice (Oryza sativa), petunia (Petunia hybrida), snapdragon (Antirrhinum majus), grapevine (Vitis vinifera L.), poplar (Populus tremuloides) and apple (Malus domestica), using both genetic and molecular analyses.…”

Section: Functions Of Mybmentioning

confidence: 99%

See 2 more Smart Citations

MYB transcription factor genes as regulators for plant responses: an overview

Ambawat

Sharma

Yadav

et al. 2013

Physiol Mol Biol Plants

838

544

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Regulation of gene expression at the level of transcription controls many crucial biological processes. Transcription factors (TFs) play a great role in controlling cellular processes and MYB TF family is large and involved in controlling various processes like responses to biotic and abiotic stresses, development, differentiation, metabolism, defense etc. Here, we review MYB TFs with particular emphasis on their role in controlling different biological processes. This will provide valuable insights in understanding regulatory networks and associated functions to develop strategies for crop improvement.

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Section: Structure Of Mybmentioning

confidence: 99%

Section: Evolution Of Mybmentioning

confidence: 99%

Section: Functions Of Mybmentioning

confidence: 99%

See 1 more Smart Citation

MYB transcription factor genes as regulators for plant responses: an overview

Ambawat

Sharma

Yadav

et al. 2013

Physiol Mol Biol Plants

838

544

View full text Add to dashboard Cite

show abstract

“…This plant-specific TF family is defined by a common DNA-binding domain of two repeats of about 50 amino acids. Examination of R2R3MYB TFs by phylogenetic analysis has revealed functionally distinct subgroups (Stracke et al, 2001;Jiang et al, 2004;Dubos et al, 2010), of which several are involved in the regulation of particular branches of phenylpropanoid metabolism; for example, anthocyanin production (PazAres et al, 1987;Quattrocchio et al, 1998;Schwinn et al, 2006), phlobaphene biosynthesis (Grotewold et al, 1994), flavonol biosynthesis (Mehrtens et al, 2005), hydroxycinnamic acid biosynthesis (Tamagnone et al, 1998;Jin et al, 2000), and monolignol biosynthesis (Zhou et al, 2009;Zhong et al, 2010). In legumes, there is an extra dimension to the regulatory control of phenylpropanoid metabolism because they produce isoflavonoids that serve as phytoalexins and as signaling molecules for nodulation (Subramanian et al, 2007).…”

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confidence: 99%

Transcription Factors of Lotus: Regulation of Isoflavonoid Biosynthesis Requires Coordinated Changes in Transcription Factor Activity

et al. 2012

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Isoflavonoids are a class of phenylpropanoids made by legumes, and consumption of dietary isoflavonoids confers benefits to human health. Our aim is to understand the regulation of isoflavonoid biosynthesis. Many studies have shown the importance of transcription factors in regulating the transcription of one or more genes encoding enzymes in phenylpropanoid metabolism. In this study, we coupled bioinformatics and coexpression analysis to identify candidate genes encoding transcription factors involved in regulating isoflavonoid biosynthesis in Lotus (Lotus japonicus). Genes encoding proteins belonging to 39 of the main transcription factor families were examined by microarray analysis of RNA from leaf tissue that had been elicited with glutathione. Phylogenetic analyses of each transcription factor family were used to identify subgroups of proteins that were specific to L. japonicus or closely related to known regulators of the phenylpropanoid pathway in other species. R2R3MYB subgroup 2 genes showed increased expression after treatment with glutathione. One member of this subgroup, LjMYB14, was constitutively overexpressed in L. japonicus and induced the expression of at least 12 genes that encoded enzymes in the general phenylpropanoid and isoflavonoid pathways. A distinct set of six R2R3MYB subgroup 2-like genes was identified. We suggest that these subgroup 2 sister group proteins and those belonging to the main subgroup 2 have roles in inducing isoflavonoid biosynthesis. The induction of isoflavonoid production in L. japonicus also involves the coordinated down-regulation of competing biosynthetic pathways by changing the expression of other transcription factors.

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“…Seven members of the proposed GRN are part of the WRKY TF family: WRKY6, WRKY15, WRKY28, WRKY30, WRKY33, WRKY40, and WRKY48, which contain a conserved sequence (WRKYGQK) followed by a zinc finger motif, enabling the binding to DNA at the position of a W‐box TTGAC(C/T) (Wu et al , 2005). Finally, three other TFs, ZAT6 and STZ, belonging to the Zinc Finger TF family (Englbrecht et al , 2004; Ciftci‐Yilmaz & Mittler, 2008; Kiełbowicz‐Matuk, 2012), and MYB51 (Stracke et al , 2001; Dubos et al , 2010), are part of the proposed mannitol‐inducible network (Appendix Table S1). …”

Section: Resultsmentioning

confidence: 99%

From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress

Broeck

Dubois

Vermeersch

et al. 2017

Molecular Systems Biology

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Plants have established different mechanisms to cope with environmental fluctuations and accordingly fine‐tune their growth and development through the regulation of complex molecular networks. It is largely unknown how the network architectures change and what the key regulators in stress responses and plant growth are. Here, we investigated a complex, highly interconnected network of 20 Arabidopsis transcription factors (TFs) at the basis of leaf growth inhibition upon mild osmotic stress. We tracked the dynamic behavior of the stress‐responsive TFs over time, showing the rapid induction following stress treatment, specifically in growing leaves. The connections between the TFs were uncovered using inducible overexpression lines and were validated with transient expression assays. This study resulted in the identification of a core network, composed of ERF6, ERF8, ERF9, ERF59, and ERF98, which is responsible for most transcriptional connections. The analyses highlight the biological function of this core network in environmental adaptation and its redundancy. Finally, a phenotypic analysis of loss‐of‐function and gain‐of‐function lines of the transcription factors established multiple connections between the stress‐responsive network and leaf growth.

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MYB transcription factors in Arabidopsis

Cited by 3,288 publications

References 111 publications

MYB transcription factor genes as regulators for plant responses: an overview

MYB transcription factor genes as regulators for plant responses: an overview

Transcription Factors of Lotus: Regulation of Isoflavonoid Biosynthesis Requires Coordinated Changes in Transcription Factor Activity

From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress

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