2021
DOI: 10.26420/austinjcancerclinres.2021.1090
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MYBL1 Knockdown in a Triple Negative Breast Cancer Line: Evidence of Down-Regulation of MYBL2, TCF19 and KIF18b Expression

Abstract: Purpose: The MYBL1 gene is a strong transcriptional activator, associated with cell cycle signaling and differentiation. Data show the gene is overexpressed in triple negative breast cancers. Considering the possibility that MYBL1 might be involved in events associated with the pathogenesis of these cancers, we sought to identify genes associated with MYBL1 expression in triple negative breast cancer. Methods: shRNA lentiviral knockdown was used to down-regulate the MYBL1 gene. Microarray analyses were used t… Show more

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(4 citation statements)
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“…In an earlier study, we performed an unsupervised meta-analysis of GEO Affymetrix microarray datasets and identified MYBL1 as differentially expressed in a subpopulation of TNBC. As a follow-up study, we performed a knockdown of MYBL1 expression in MDA-MB-231 cells, followed by microarray analyses to determine genes that either directly or indirectly associate with MYBL1 in the TNBC [ 18 ]. Reprocessing the differentially expressed dataset, we identified genes at chromosome 8q loci that were either upregulated or downregulated following MYBL1 gene knockdown ( Supplemental Table S1 ).…”
Section: Resultsmentioning
confidence: 99%
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“…In an earlier study, we performed an unsupervised meta-analysis of GEO Affymetrix microarray datasets and identified MYBL1 as differentially expressed in a subpopulation of TNBC. As a follow-up study, we performed a knockdown of MYBL1 expression in MDA-MB-231 cells, followed by microarray analyses to determine genes that either directly or indirectly associate with MYBL1 in the TNBC [ 18 ]. Reprocessing the differentially expressed dataset, we identified genes at chromosome 8q loci that were either upregulated or downregulated following MYBL1 gene knockdown ( Supplemental Table S1 ).…”
Section: Resultsmentioning
confidence: 99%
“…Data show that the gene is over-expressed in tumor progressions [ 62 ], confers chemoresistance in TNBC samples [ 63 ], and functions via mitogen-activated protein kinase (MAPK) signaling [ 64 ]. In the current study, the BOP1 gene was over-expressed in TNBC cell lines [ 18 ] and patient samples along with MYBL1, VCPIP1 and MYC genes. Patient sample data show a close relationship between MYBL1 and BOP1; however, in the GENE description of BOP1 located at NCBI, 175 genes are defined as interacting with BOP1, one of which is MYC gene based on affinity capture Mass Spectrometry ( , accessed on 1 February 2024); there is no mention of MYBL1.…”
Section: Discussionmentioning
confidence: 97%
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