Mycetoma

Mahgoub, Elsheikh

doi:10.1016/b978-0-443-06668-9.50083-1

Cited by 4 publications

(8 citation statements)

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“…[1] Actinomycetoma is one of the most neglected diseases and is considered a major health problem in several parts of Sudan. [2][3][4] Geographical distribution of mycetoma causative agents show considerable variations which could be explained by several environmental factors, specially the rainfall. [1,5] The major agents of aerobic actinomycetes are: Nocardia brasiliensis, Actinomadura madurae, and Streptomyces somaliensis.…”

Section: Introductionmentioning

confidence: 99%

Isolation and molecular identification of actinomycetes from mycetoma patients in Sudan

Elhassan¹,

Yousif²,

Elmekki³

et al. 2013

Ann Trop Med Public Health

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Introduction:In order to minimize chance of amputation due to actinomycetoma, it is important to correctly identify the causative agents. Microscopic examination of grains is not definite and further confirmatory diagnostic tests are needed. This study aims to investigate the prevalence of actinomycetoma and to explore the usefulness of strb1 gene in the diagnosis of the disease. Materials & Methods: The present study is a prospective cross-section laboratory-based study in which clinical samples (n = 100) from patients with mycetoma lesions were collected. The samples were cultured on Lowenstein Jensen and glucose yeast extract agar media. Grown colonies were initially identified using Gram's stain, Ziehl Neelsen stain, and selected biochemical reactions. Confirmation was done by the analysis of polymerase chain reaction amplified strb1 gene. Results: Actinomycetoma was represented by a high ratio (12%) among the study population. Nine out of the 12 isolates (75%) were found to belong to the genus Streptomyces; whereas three isolates (25%) were identified as Nocardia spp. on the basis of phenotypic and mycolic acid contents. Conclusion: It could be concluded that actinomycetoma exists with significant prevalence (12%) among patients investigated in the present study. Streptomyces is the most important etiological agent of actinomycetoma compared to Nocardia.

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Section: Introductionmentioning

confidence: 99%

Isolation and molecular identification of actinomycetes from mycetoma patients in Sudan

Elhassan¹,

Yousif²,

Elmekki³

et al. 2013

Ann Trop Med Public Health

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“…The disease is endemic in the mycetoma belt between latitude 15 South and 30 North. Mycetomas are frequent in the tropical zones of Asia (India) [7][8][9][10][11], Africa (Senegal, Mauritius, and Sudan) [4,14,15] and America (Mexico, Brazil, Venezuela) [16,17]. Madurella mycetomatis and Streptomyces somaliensis predominate in tropical parts of Africa and Asia.…”

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confidence: 99%

“…Poor hygiene, low socioeconomic status, and low nutrition are the suggested risk factors. The causative agent that exists as saprophytes usually gains entry into the subcutaneous tissue through abrasions or implantation [4,6,8,18,19]. Infection begins in the skin and subcutaneous tissue causing local popular or nodular swelling that tends to grow and rupture, forming communicating sinus tracts through which grains are discharged.…”

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confidence: 99%

Actinomycetoma-The Welsh Regimen in a Rural Indian Scenario

Mathews¹,

Jadhav²,

Reza³

et al. 2012

Indian J Surg

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We describe a case of Actinomycetoma foot which presented to us after 3yrs of onset of symptoms.We have attempted a chemotherapeutic treatment regime and are reporting the healing changes that have taken place radiologically and macroscopically. A review of literature has been done of various treatment regimens used for Actinomycetoma foot and used and their practical applications in rural hospital.

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“…It is mainly prevalent in tropical rural areas in a belt that matches the Acacia belt in Africa, India, Central and South America (1,2,3). Mycetoma is a major health problem in Sudan notably among rural workers, particularly male farmers, peasant and shepherds.…”

Section: Introductionmentioning

confidence: 99%

“…Actinomycetoma is reportedly caused by Actinomadura madurae, A. pelletieri, Nocardia brasiliensis, N. otitidiscaviarum, N. transvalensis, Streptomyces sudanesnsis and S. somaliensis (4,5). Most mycetoma cases in Sudan are attributed to S. somaliensis (1,6) and S. sudanesnsis (5). Currently, the genus Streptomyces includes over 500 validly described species (7, www.ncbi.nlm.nih.gov/Taxonomy/).…”

Section: Introductionmentioning

confidence: 99%

The use of morphological and cell wall chemical markers in the identification of <i>Streptomyces</i> species associated with Actinomycetoma

Hamid¹

2013

Af J Clin Exp Micro

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Most aerobic, filamentous, spore-forming Actinomycetes are saprophytes but some are considered pathogens of humans and animals, notable examples are the causal agents of mycetoma. The present study aimed to identify Streptomyces spp. isolated from actinomycetoma cases in Sudan by examining some morphological traits and analyzing the cell wall composition. Nineteen Streptomyces strains isolated from purulent materials of patients with mycetoma (human) or fistulous withers (donkeys) were included in the study. Isolates were tentatively identified as Streptomyces species based on morphological and cultural characteristics. Cell wall analysis of isolates yielded LLdiaminopimelic acid (LL-DAP) which authenticates that the isolates are members of genus Streptomyces. The isolates, though they are Streptomyces, but are variable phenotypes. The study concluded that using few selected criteria, as above, would allow identification of unknown actinomycetoma agent to the genus level. The study also assumes that apparently limitless, numbers of saprophytic Streptomyces enter human or animal skin tissue causing actinomycetoma and perhaps other complications in man and animals.

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Mycetoma

Cited by 4 publications

References 0 publications

Isolation and molecular identification of actinomycetes from mycetoma patients in Sudan

Isolation and molecular identification of actinomycetes from mycetoma patients in Sudan

Actinomycetoma-The Welsh Regimen in a Rural Indian Scenario

The use of morphological and cell wall chemical markers in the identification of <i>Streptomyces</i> species associated with Actinomycetoma

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