Mycobacterial infection alters host mitochondrial activity

Mohareer, Krishnaveni; Banerjee, Sharmistha

doi:10.1016/bs.ircmb.2023.01.007

Cited by 2 publications

(1 citation statement)

References 75 publications

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“…Mtb alters the mitochondrial morphology, metabolism, and functions, markedly impacting macrophage immunometabolism and thereby influencing the effectiveness of host antimicrobial defenses and the outcomes of infection ( 50 ). Metabolic reprogramming occurs in alveolar and bone marrow–derived macrophages during Mtb infection ( 51 ).…”

Section: Role Of Tnf In Protective Immunity During Mycobacterial Infe...mentioning

confidence: 99%

TNF in Human Tuberculosis: A Double-Edged Sword

Yuk,

Kim,

Kim

et al. 2024

Immune Netw

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TNF, a pleiotropic proinflammatory cytokine, is important for protective immunity and immunopathology during Mycobacterium tuberculosis (Mtb) infection, which causes tuberculosis (TB) in humans. TNF is produced primarily by phagocytes in the lungs during the early stages of Mtb infection and performs diverse physiological and pathological functions by binding to its receptors in a context-dependent manner. TNF is essential for granuloma formation, chronic infection prevention, and macrophage recruitment to and activation at the site of infection. In animal models, TNF, in cooperation with chemokines, contributes to the initiation, maintenance, and clearance of mycobacteria in granulomas. Although anti-TNF therapy is effective against immune diseases such as rheumatoid arthritis, it carries the risk of reactivating TB. Furthermore, TNF-associated inflammation contributes to cachexia in patients with TB. This review focuses on the multifaceted role of TNF in the pathogenesis and prevention of TB and underscores the importance of investigating the functions of TNF and its receptors in the establishment of protective immunity against and in the pathology of TB. Such investigations will facilitate the development of therapeutic strategies that target TNF signaling, which makes beneficial and detrimental contributions to the pathogenesis of TB.

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Section: Role Of Tnf In Protective Immunity During Mycobacterial Infe...mentioning

confidence: 99%

TNF in Human Tuberculosis: A Double-Edged Sword

Yuk,

Kim,

Kim

et al. 2024

Immune Netw

View full text Add to dashboard Cite

show abstract

Toxoplasma gondii macrophage migration inhibitory factor shows anti– Mycobacterium tuberculosis potential via AZIN1/STAT1 interaction

Yoon,

Kim,

Ham

et al. 2024

Sci. Adv.

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Mycobacterium tuberculosis (MTB) is a pathogenic bacterium, belonging to the family Mycobacteriaceae , that causes tuberculosis (TB). Toxoplasma gondii macrophage migration inhibitory factor (TgMIF), a protein homolog of macrophage migration inhibitory factor, has been explored for its potential to modulate immune responses during MTB infections. We observed that TgMIF that interacts with CD74, antizyme inhibitor 1 (AZIN1), and signal transducer and activator of transcription 1 (STAT1) modulates endocytosis, restoration of mitochondrial function, and macrophage polarization, respectively. These interactions promote therapeutic efficacy in mice infected with MTB, thereby presenting a potential route to host-directed therapy development. Furthermore, TgMIF, in combination with first-line TB drugs, significantly inhibited drug-resistant MTB strains, including multidrug-resistant TB. These results demonstrate that TgMIF is potentially a multifaceted therapeutic agent against TB, acting through immune modulation, enhancement of mitochondrial function, and dependent on STAT1 and AZIN1 pathways.

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Mycobacterial infection alters host mitochondrial activity

Cited by 2 publications

References 75 publications

TNF in Human Tuberculosis: A Double-Edged Sword

TNF in Human Tuberculosis: A Double-Edged Sword

Toxoplasma gondii macrophage migration inhibitory factor shows anti– Mycobacterium tuberculosis potential via AZIN1/STAT1 interaction

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