Mycobacterium abscessus, an Uncommon Cause of Chronic Otitis Media

Linmans, Joris; Stokroos, Robert J.; Linssen, Catharina F. M.

doi:10.1001/archotol.134.9.1004

Cited by 22 publications

(17 citation statements)

References 13 publications

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“…massiliense chronic otitis media. Several cases of pediatric chronic otitis media caused by M. abscessus have been reported (Franklin et al, 1994;Nylén et al, 1994;Linmans et al, 2008;Aarem et al, 1998;Ferguson and Salusbury, 1996), and a regimen containing multiple agents, including a macrolide, has most often been selected for treatment, concurrent with mastoidectomy. Tigecycline is a new option that is particularly useful for cases of extensive resistance.…”

Section: Discussionmentioning

confidence: 99%

“…In the pediatric population, M. abscessus complex has been reported to be the most frequently isolated organism in otitis media and otomastoiditis caused by non-tuberculous mycobacteria (Lee et al, 2012). However, the incidence of mycobacterial otitis media is not known, although it would appear to be rare given the limited number of cases reported in the literature (Franklin et al, 1994;Nylén et al, 1994;Linmans et al, 2008;Aarem et al, 1998;Ferguson and Salusbury, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Chronic otitis media caused by Mycobacterium abscessus spp. massiliense treated with tigecycline in a 10-year-old child

Myojin

Fukuoka

Kanemaru

et al. 2018

International Journal of Infectious Diseases

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Mycobacterium abscessus is one of the most pathogenic and chemotherapy-resistant rapidly growing mycobacteria. This Mycobacterium should always be considered as a possible cause of chronic otitis media in children, and treatment might be challenging because of its resistance to multiple antibiotics. There are no reports describing the therapeutic use of tigecycline for the treatment of chronic otitis media caused by M. abscessus. A 10-year-old boy was referred to Tokyo Metropolitan Children's Medical Center with a 7-year history of recurrent otitis media despite treatment with antibiotics and ventilation tubes. Cultures of the otorrhea yielded Mycobacterium abscessus spp. massiliense, and it showed multiple and high-level resistance. The boy required surgery and underwent initial treatment with clarithromycin, amikacin, and tigecycline for 4 weeks. He experienced emesis as a side-effect of tigecycline, which was well controlled with ondansetron. He was treated successfully with 3 months of subsequent oral clarithromycin and linezolid. This is the first pediatric case of chronic otitis media caused by M. abscessus treated with a tigecycline-containing regimen. Although the therapeutic use of tigecycline remains controversial, especially in the pediatric population, it can be an acceptable option in the treatment of chronic otitis media caused by M. abscessus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic otitis media caused by Mycobacterium abscessus spp. massiliense treated with tigecycline in a 10-year-old child

Myojin

Fukuoka

Kanemaru

et al. 2018

International Journal of Infectious Diseases

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“…Foreign body-associated MABSC infections are increasingly recognised now receiving increasing emphasis because of the increased use of indwelling medical devices29. The presence of a foreign body is believed to facilitate colonisation by weakening host barrier defence mechanisms30. An individual case of perigastrostomy infection caused by M abscessus in an immunocompetent patient has been reported31.…”

Section: Discussionmentioning

confidence: 99%

Nontuberculous mycobacteria in gastrostomy fed patients with cystic fibrosis

Al-Momani

Perry

Jones

et al. 2017

Sci Rep

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Multi-drug resistant Mycobacterium abscessus complex (MABSC) is a form of Nontuberculous mycobacteria (NTM) of special, international concern in Cystic Fibrosis (CF). We hypothesised that gastric juice and percutaneous endoscopic gastrostomy (PEG) feeding devices might yield MABSC isolates. Gastric juice and sputa from sixteen adult PEG fed CF patients and five replaced PEG tubes were studied. Bacterial and fungal isolates were cultured. Mycobacterium were identified by rpoB, sodA and hsp65 gene sequencing and strain typed using variable number tandem repeat. Bacteria and/or fungi grew from all gastric juice, sputa and PEG samples. MABSC were detected in 7 patients. Five had MABSC in their sputum. Two had an identical MABSC strain in their sputum and gastric juice and one had the same strain isolated from their PEG tube and sputum. Two patients who were sputum sample negative had MABSC isolated in their gastric juice or PEG tube. MABSC were therefore identified for the first time from a gastric sample in a minority of patients. We conclude that gastric juice and PEG-tubes may be a potential source of MABSC isolates in CF patients, and these findings warrant further study.

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“…Spontaneous recovery of NTM ear infection is rare. Any foreign material should be removed (tympanostomy tubes) and affected tissue surgically removed [7,12]. Antibiotic therapy should continue at least 2-3 months after disappearance of symptoms [8].…”

Section: Discussionmentioning

confidence: 99%

“…Rarely, NTM can also cause chronic ear infections and mastoiditis [6][7][8][9][10]. Mycobacterium abscessus belongs to the rapidly growing mycobacteria and is considered to be the most dangerous, pathogenic, and therapy-resistant of the NTMs [5].…”

Section: Introductionmentioning

confidence: 99%