Mycobacterium abscessus complex: A Review of Recent Developments in an Emerging Pathogen

Victoria, Laura; Gupta, Amolika; Gómez, José L.; Robledo, Jaime

doi:10.3389/fcimb.2021.659997

Cited by 83 publications

(80 citation statements)

References 76 publications

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“…Although MABC members are generally ubiquitous and their isolation from the respiratory tract does not always indicate a state of disease [32], the potential for personto-person transmission makes identification at the subspecies level mandatory because of differences in antibiotic susceptibility profiles and treatment outcomes. Additionally, MABC infections are difficult to treat because these organisms are resistant to conventional tuberculosis therapies and most antimicrobial agents [33,34].…”

Section: Discussionmentioning

confidence: 99%

An Artefactual Cluster of Mycobacterium abscessus Pneumonia among Cancer Patients Arising from Contamination

et al. 2022

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The Mycobacteriumabscessus complex (MABC) is a group of rapidly growing, nontuberculous mycobacteria that are ubiquitous in soil, urban water pipes, swimming pools, and drinking water. Members of the MABC are considered opportunistic pathogens. The aim of this study was to investigate the origins of MABC detected in broncho-lavage (BL) samples from asymptomatic cancer patients. We turned our attention to washing and disinfection procedures for bronchoscopes; we also assessed water and disinfectant samples. Of 10 BL and 34 environmental samples tested, four BL samples (40%) and seven environmental samples (20.6%) tested positive for MABC. We hypothesized that contamination could arise from the prewashing machine and/or the water used because no patient had clinical or radiological signs consistent with MABC respiratory tract infection. Our study highlights the importance of evaluating cleaning and disinfection procedures for endoscope channels to reduce the potential spread of microorganisms and artefactual results arising from contamination.

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Section: Discussionmentioning

confidence: 99%

An Artefactual Cluster of Mycobacterium abscessus Pneumonia among Cancer Patients Arising from Contamination

et al. 2022

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“…This species is also considered the most antibiotic-resistant of all the mycobacteria [ 3 ]. As per a study, it was estimated that MABC represented 3-13% of all NTM-PD [ 4 ]. Out of the MABC, M. abscessus is the most common isolate, followed by M. massiliense and M. bolletii [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Mycobacterium abscessus: An Emerging Pathogen

Chohan¹,

Choudhury²,

Taweesedt³

et al. 2022

Cureus

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The incidence of infections by rapidly growing mycobacteria has increased in recent decades. nontuberculous mycobacteria (NTM) represent over 190 species and subspecies and can cause both pulmonary and extrapulmonary symptoms. The Mycobacterium abscessus complex (MABC) is among the most drugresistant mycobacterial species, and prompt diagnosis and effective eradication are burdensome. We present the clinical course of a 55-year-old female who was diagnosed with M. abscessus and explore her clinical diagnosis and possible treatment options. This case report emphasizes the challenges clinicians face in the prompt diagnosis of M. abscessus and discusses the treatment options in light of the recent guidelines.

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“…In this study, we describe a medium-throughput bioluminescence-based pipeline to screen fungi for activity against Mycobacteria using bioluminescent derivates of M. abscessus and M. marinum as the testing strains. We included M. abscessus as it is a relatively fast-growing non-tuberculous mycobacterial species and is a cause of opportunistic infections in patients with cystic fibrosis or chronic pulmonary disease, and of skin and soft tissue infections, for which treatment options are limited ( To et al, 2020 ; Victoria et al, 2021 ). We also included M. marinum as, despite being a pathogen of fish, amphibians, and reptiles, it shares conserved virulence determinants with M. tuberculosis ( Bouz and Al Hasawi, 2018 ; Ramakrishnan, 2020 ) and is a Biosafety Level (BSL) 2 rather than an airborne BSL 3 organism.…”

Section: Discussionmentioning

confidence: 99%

Screening of Fungi for Antimycobacterial Activity Using a Medium-Throughput Bioluminescence-Based Assay

et al. 2021

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There is a real and urgent need for new antibiotics able to kill Mycobacteria, acid-fast bacilli capable of causing multiple deadly diseases. These include members of the Mycobacterium tuberculosis complex, which causes the lung disease tuberculosis (TB) as well as non-tuberculous Mycobacteria (NTM) a growing cause of lung, skin, soft tissue, and other infections. Here we describe a medium-throughput bioluminescence-based pipeline to screen fungi for activity against Mycobacteria using the NTM species Mycobacterium abscessus and Mycobacterium marinum. We used this pipeline to screen 36 diverse fungal isolates from the International Collection of Microorganisms from Plants (ICMP) grown on a wide variety of nutrient-rich and nutrient-poor media and discovered that almost all the tested isolates produced considerable anti-mycobacterial activity. Our data also provides strong statistical evidence for the impact of growth media on antibacterial activity. Chemical extraction and fractionation of a subset of the ICMP isolates revealed that much of the activity we observed may be due to the production of the known anti-mycobacterial compound linoleic acid. However, we have identified several ICMP isolates that retained their anti-mycobacterial activity in non-linoleic acid containing fractions. These include isolates of Lophodermium culmigenum, Pseudaegerita viridis, and Trametes coccinea, as well as an unknown species of Boeremia and an isolate of an unknown genus and species in the family Phanerochaetaceae. Investigations are ongoing to identify the sources of their anti-mycobacterial activity and to determine whether any may be due to the production of novel bioactive compounds.

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Mycobacterium abscessus complex: A Review of Recent Developments in an Emerging Pathogen

Cited by 83 publications

References 76 publications

An Artefactual Cluster of Mycobacterium abscessus Pneumonia among Cancer Patients Arising from Contamination

An Artefactual Cluster of Mycobacterium abscessus Pneumonia among Cancer Patients Arising from Contamination

A Case Report on Mycobacterium abscessus: An Emerging Pathogen

Screening of Fungi for Antimycobacterial Activity Using a Medium-Throughput Bioluminescence-Based Assay

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