Mycobacterium abscessus Infection After Facial Injection With Autologous Fat

Yang, Ping; Lu, Yongzhou; Liu, Tianyi; Zhou, Yiqun; Guo, Yu; Zhu, Jianmin; Jia, Chuanlong; Chen, Liang; Yang, Qingjian

doi:10.1097/sap.0000000000000837

Cited by 11 publications

(14 citation statements)

References 9 publications

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“…To meet the challenge of NTM diagnosis and management, we should learn more about it. In Table 1 , previous cases of mycobacterial infections caused by cosmetic performance are reviewed[ 2 - 4 , 6 - 14 ], the results of which are consistent with the previous studies[ 1 ]. It is common to be seen in female patients aged 25 to 45 years.…”

Section: Discussionsupporting

confidence: 83%

Subcutaneous infection caused by Mycobacterium abscessus following cosmetic injections of botulinum toxin: A case report

Lin¹,

Luo²,

Liu³

et al. 2022

WJCC

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BACKGROUND In recent years, the cosmetic intervention related infections caused by nontuberculous mycobacteria (NTM) are increasing as the informal cosmetic treatments are performed. However, many dermatologists are inexperienced in the diagnosis and management of similar cases. Here we report a case of subcutaneous infection caused by Mycobacterium abscessus ( M. abscessus ) following cosmetic injections of botulinum toxin. CASE SUMMARY A 53-year-old woman presented with multiple abscesses and nodules on her forehead and both temporal sites for half a month after cosmetic injections of botulinum toxin. Her lesions did not show any alleviation after 2-wk prescription of antibiotics. Laboratory examinations indicated that she had no sign of immunodeficiency and the whole body of computed tomography did not find any systemic infection or diseases. The pathology of skin tissue showed inflammatory cell infiltration with the negative results of Periodic acid Schiff (PAS) and Acid-fast staining and the culture yielded no microbiome. Afterwards, the puncture on abscess was performed and M. abscessus was successfully isolated. The pathogen was identified by acid-fast staining and DNA sequencing. The patient was treated with the strategy of clarithromycin, ofloxacin, and amikacin according to the result of drug sensitivity test and got complete remission of the lesions. CONCLUSION The case presents the whole process of diagnosis and management of NTM infection after cosmetic intervention and highlights the diagnostic thoughts. In a word, the mycobacterium infection should be aware in patients after cosmetic performance.

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Section: Discussionsupporting

confidence: 83%

Subcutaneous infection caused by Mycobacterium abscessus following cosmetic injections of botulinum toxin: A case report

Lin¹,

Luo²,

Liu³

et al. 2022

WJCC

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“…The present three-year study found that M. marinum infections were predominant over other mycobacterial species in causing cutaneous mycobacterial infections, a trend that has been previously reported ( Mei et al., 2019 ). The surge of M. abscessus infection among young women, with the emergence of diverse unscheduled cosmetic infections, made it the second most causative pathogen of cutaneous mycobacterial infections ( Eustace et al., 2016 , Yang et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

DNA microarray chip assay in new use: early diagnostic value in cutaneous mycobacterial infection

Wang

Gao

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionThe clinical practicability of DNA microarray chip in detecting the presence of mycobacterial species/isolates directly in the skin tissues has not been evaluated, nor the efficacy of DNA microarray chip as a novel diagnostic tool for the early diagnosis of cutaneous mycobacterial infections is known.MethodsThe present study analyzed the incidence of cutaneous mycobacterial infections in Shanghai and explored the efficacy of a novel DNA microarray chip assay for the clinical diagnosis of the disease from skin tissue specimens compared to traditional detection methods. A total of 60 participants fulfilling the defined diagnostic criteria and confirmed positive for cutaneous mycobacterial infections from 2019 to 2021 were enrolled in the study. Subsequent to recording the participants’ medical history and clinical characteristics, the skin tissue specimens were collected for analyses. The specimens underwent histopathological analyses, skin tissue culture, and DNA microarray chip assay.ResultsIncreased incidence of cutaneous mycobacterial infection was detected from 2019 to 2021. The most common infecting pathogen was M. marinum followed by M. abscessus. The sensitivity, specificity and accuracy of the skin tissue culture method were 70%, 100% and 76.62%, respectively, while that of the DNA microarray chip assay were 91.67%, 100% and 93.51%, respectively. The sensitivity and accuracy of the DNA microarray chip assay were significantly higher than those of the skin tissue culture method. The positive likelihood and diagnostic odds ratio were >10 and >1, respectively for both the methods. The negative likelihood ratio was significantly higher (30% vs 8.33%) and the Youden’s index was significantly lower (70.00% vs 91.67%) in the skin culture method compared to that of the DNA microarray chip assay. There was a significant association of false negative results with a history of antibiotic use in the skin tissue culture method.DiscussionGiven the increasing incidence of cutaneous mycobacterial infections, early diagnosis remains a prime clinical focus. The DNA microarray chip assay provides a simple, rapid, high-throughput, and reliable method for the diagnosis of cutaneous mycobacterial infections with potential for clinical application.

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“…Blood examination showed normal ALT, total bilirubin levels, and electrolyte levels [20,22,23]. However, on one hand, some studies indicated normal levels of white blood count, and other studies showed a mild elevation in the other hand [19,[22][23][24][25][26][27]. The level of C-reactive protein was also normal in some investigations [19,[22][23][24][25].…”

Section: Paraclinical Characteristicsmentioning

confidence: 95%

“…On ultrasound results, there could be scattered abscesses, fluid fat foci, or heterogeneous irregulatory and hypoechoic injuries [22,24,27,[34][35][36]. Histopathologic images showed ulcerous or granular lesions [23,34,37,38].…”

Section: Paraclinical Characteristicsmentioning

confidence: 99%

Postoperative infection mycobacterium abscessus associated with liposuction and autologous fat grafting: A narrative review

Hoang,

Nguyen,

Nguyen

et al. 2023

yhthvb

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Liposuction and autologous fat grafting are common aesthetic procedures these days. Although these procedures are relatively safe, some severe complications sometimes happen affecting aesthetic results and the patient’s quality of life. Postoperative infection of Mycobacterium abscessus after liposuction and autologous fat grafting is an uncommon complication along with untypical symptoms. This results in misdiagnosis and delays in proper diagnosis and treatments, prolonging the treatment period. This narrative review summarises cases of M. abscessus infection associated with liposuction and autologous fat grafting, then presents causes, diagnoses, preventive care, and treatments of such cases. This aims to enhance the awareness of this infection after aesthetic surgery and contributes to the appropriate prevention and treatment.

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Mycobacterium abscessus Infection After Facial Injection With Autologous Fat

Cited by 11 publications

References 9 publications

Subcutaneous infection caused by Mycobacterium abscessus following cosmetic injections of botulinum toxin: A case report

Subcutaneous infection caused by Mycobacterium abscessus following cosmetic injections of botulinum toxin: A case report

DNA microarray chip assay in new use: early diagnostic value in cutaneous mycobacterial infection

Postoperative infection mycobacterium abscessus associated with liposuction and autologous fat grafting: A narrative review

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