Mycobacterium agri Skin Infection in a Previously Healthy Patient: A Case Study

Xu, Chengan; Wu, Wenhao; Pan, Heng; Hui, Tian-Chen; Wu, Qingqing; Zhou, Zhewen; Wang, Shouhao; Zheng, Wei; Yi, Qiaoqiao; Pan, Hongying

doi:10.2147/idr.s322717

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Potentially all NTM species can cause skin infections; however, for the slow growing mycobacterium (SGM) M. marinum , the skin is the typical site of infection, and the rapidly growing mycobacteria (RGM) M. fortuitum , M. abscessus and M. chelonae may also give cutaneous disease. MAC complex [ 44 ] and less pathogenic NTM may also determine SSTIs, as reported for M. haemophilum [ 7 , 45 , 46 ], M. gordonae [ 47 ] and M. agri [ 48 ].…”

Section: Mycobacterial Skin Infectionsmentioning

confidence: 99%

Mycobacterial skin infection

Giannotti

Gregori

Matteelli

et al. 2022

Current Opinion in Infectious Diseases

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Purpose of review The aim of this article is to review the most recent evidences concerning mycobacterial skin infections, limiting the period of literature research to 2020--2021. Recent findings Mycobacterial skin infections include a heterogeneous group of cutaneous diseases. Cutaneous tuberculosis is usually the result of hematogenous dissemination or spread from underlying foci and it must be distinguished from tuberculids, resulting from the immunological reaction to Mycobacterium tuberculosis antigens. Leprosy prevalence was drastically reduced after introduction of multidrug therapy in the 1980 s, but cases are still reported due to underdiagnosis, and animal and environmental reservoirs. Recent advances concentrate in the diagnostic field. Specific guidelines for the treatment of nontuberculous mycobacteria skin infections are missing and surgical procedures may be required. Prognosis is better as compared to nontuberculous mycobacteria lung disease. Rapid laboratory-confirmed diagnosis of Buruli ulcer may be achieved by the IS2404 PCR. Among new drugs, telacebec is promising in terms of potency, shorter duration and tolerability in animal studies. A clinical trial in humans is planned. Summary Mycobacterial cutaneous lesions are nonpathognomonic and clinical suspicion must be confirmed by culture or molecular detection. Long-course multidrug treatment is required based on susceptibility tests. Surgical intervention may also be required. Rehabilitation and psychosocial support reduce long-term physical and mental consequences mostly in Buruli ulcer and leprosy.

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Section: Mycobacterial Skin Infectionsmentioning

confidence: 99%

Mycobacterial skin infection

Giannotti

Gregori

Matteelli

et al. 2022

Current Opinion in Infectious Diseases

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“… 3 At present, there are only a few reports of cosmetics-related NTM infection in China, and the incidence of cosmetics-induced NTM infection in China is unclear. 4 , 5 Herein, we report two patients with M. smegmatis infection associated with cosmetic procedures/injections to raise medical providers’ awareness. To our knowledge, only one case of M. smegmatis infection related to cosmetic procedures has been reported in China.…”

Section: Introductionmentioning

confidence: 96%

Mycobacterium smegmatis Skin Infection Following Cosmetic Procedures: Report of Two Cases

Wang¹,

Song²,

Li³

et al. 2022

CCID

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Mycobacterium smegmatis is an acid-fast bacillus of rapidly growing mycobacteria (RGM) of nontuberculous mycobacteria (NTM). M. smegmatis was considered nonpathogenic to humans until 1986, when the first patient was linked to the infection. To date, fewer than 100 cases have been reported in the literature, mainly related to various surgical procedures. Herein, we report two immunocompetent patients who acquired M. smegmatis infection following cosmetic procedures. Due to the rarity of M. smegmatis infection in routine clinical practice, it is challenging for medical providers to diagnose and treat patients with M. smegmatis infection. M. smegmatis infection should be considered for patients with chronic skin and soft tissue infections at the injection site or surgical site following cosmetic procedures. Histological findings, pathogen identification by molecular testing or bacterial culture are required to make a definitive diagnosis. Medical providers should raise awareness of M. smegmatis infection for patients with chronic skin and soft tissue infections after cosmetic procedures. Stringent sterile procedures for surgical instruments, supplies, and environments should be enforced.

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The Price of Beauty: A Literature Review on Non-Tuberculous Mycobacteria Infection After Cosmetic Procedures

Ren,

Xiao,

Tang

et al. 2024

Aesthetic Surgery Journal

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Non-tuberculous mycobacteria (NTM) infection of the skin and soft tissues is a complication of cosmetic procedures. The incidence of cutaneous NTM infections has increased significantly as aesthetic operations have become more commonplace. With the rise of cosmetic tourism, the geographic expansion of NTM infections is a major concern. Due to the unique pathogenesis of NTM infections, diagnosis and treatment remain significant challenges for clinicians. Clinical management relies on a combination of antibiotic therapy with drug susceptibility testing and appropriate surgical debridement. Some new drugs, photodynamic therapy, and bacteriophage therapy have been developed in recent years, and may improve the aesthetic outcomes. This review summarizes the cosmetic procedures prone to NTM infections in recent years and their clinical features. We propose a 2-stage treatment procedure, including a hospitalization phase and a follow-up phase. We aim to increase the alertness of clinicians to NTM infections for timely detection and treatment. Level of Evidence: 3

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Mycobacterium agri Skin Infection in a Previously Healthy Patient: A Case Study

Cited by 4 publications

References 18 publications

Mycobacterial skin infection

Mycobacterial skin infection

Mycobacterium smegmatis Skin Infection Following Cosmetic Procedures: Report of Two Cases

The Price of Beauty: A Literature Review on Non-Tuberculous Mycobacteria Infection After Cosmetic Procedures

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