Mycobacterium avium subspecies paratuberculosis in children with early-onset crohnʼs disease

Wagner, Josef; Sim, Winnie H.; Bishop, Ruth F.; Catto‐Smith, Anthony G.; Cameron, Donald J. S.; Kirkwood, Carl D.

doi:10.1002/ibd.21603

Cited by 14 publications

(6 citation statements)

References 7 publications

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“…So, infected cats can bring MAP to your house to contaminate the household environment as well as your food with this robust harmful bacterium. Special attention should be paid for children as in the last few years there is a growing increase in the incidence of pediatric Chron's disease while MAP was isolated from the gut tissues and blood from children with Chron's disease (Kirkwood et al, 2009;Wagner et al, 2011). Also, MAP was implicated in autism in children, which may complicate MAP infections in children (Daw 2011).…”

Section: Discussionmentioning

confidence: 99%

Detection of Mycobacterium avium subsp. paratuberculosis in an Egyptian mixed breeding farm and comparative molecular characterisation of isolates from cattle, camels and cats – a case report

Salem¹,

El-Deeb²,

Abdel-Moein³

et al. 2019

BJVM

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The present study records and investigates an outbreak of Johne’s Disease in a mixed breeding camel – cattle farm and the possible role of non-domestic non-ruminants animals in the epidemiology of Mycobacterium avium subspecies paratuberculosis in Egypt. For this reason, faecal samples were collected from 24 dairy cattle and from 15 one humped Arabian camels suffering from diarrhoea. Moreover, intestinal tissue samples were provided from 7 cats and 2 rats that were caught from the same farm and were euthanized before necropsy. Samples were examined using traditional culture and IS900 PCR techniques together with the application of BstEII-IS900 RFLP for typing of obtained isolates. Interestingly, MAP was recovered from cattle (n=8) and from camels (n=3) and non-domestic cats (n=3) reared under local conditions in this farm in Egypt. The obtained results highlight the potential role of cats in the epidemiology of MAP, a subject which needs further investigation and might have a public health importance, catsbeing common members of many families.

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Section: Discussionmentioning

confidence: 99%

Detection of Mycobacterium avium subsp. paratuberculosis in an Egyptian mixed breeding farm and comparative molecular characterisation of isolates from cattle, camels and cats – a case report

Salem¹,

El-Deeb²,

Abdel-Moein³

et al. 2019

BJVM

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“…This inconsistency has not been explained in the literature, but may be due to true differences in prevalence, differences in test sensitivity and detection limits or even variation in sampling strategy. To complicate this further, a small cohort study by Wagner et al [47] demonstrated that some CD patients intermittently test positive for M. paratuberculosis by PCR over time and infection may persist despite antimicrobial treatment. Research has not adequately addressed the effects of stage of disease and various treatments on the outcome of M. paratuberculosis testing and there is conflicting results on the relationship between M. paratuberculosis test results and CD activity status (measure of disease symptoms occurring at the time of sample collection) [86,87,[115][116][117].…”

Section: Discussionmentioning

confidence: 99%

“…There were 116 studies that contributed 163 lines of data summarized in Tables 1-4 on the association of M. paratuberculosis with CD (96 studies), HIV (2), sarcoidosis (3), T1DM (7), T2DM (3), multiple sclerosis (5), Hashimoto's thyroiditis (2). Five studies with varying study designs and objectives looked at evidence for an association between Johne's disease and CD including two cross-sectional studies examining high exposure occupations and CD [45,46], one case series that tested newly diagnosed CD patients over 5 years for M. paratuberculosis [47] and two challenge trials that investigated whether M. paratuberculosis isolates from humans could produce Johne's disease in goats [48,49]. Seven molecular epidemiology studies looked at the relatedness of M. paratuberculosis isolates from a variety of species including humans [50][51][52][53][54][55][56].…”

Section: Description Of Relevant Studiesmentioning

confidence: 99%

The zoonotic potential ofMycobacterium aviumssp.paratuberculosis: a systematic review and meta-analyses of the evidence

et al. 2015

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This systematic review-meta-analysis appraises and summarizes all the available research (128 papers) on the zoonotic potential of Mycobacterium avium ssp. paratuberculosis. The latter has been debated for a century due to pathogenic and clinical similarities between Johne's disease in ruminants and Crohn's disease (108 studies) in humans and recently for involvement in other human diseases; human immunodeficiency virus (HIV) infection (2), sarcoidosis (3), diabetes mellitus type 1 (T1DM) (7) and type 2 (3), multiple sclerosis (5) and Hashimoto's thyroiditis (2). Meta-analytical results indicated a significant positive association, consistently across different laboratory methods for Crohn's disease [odds ratio (OR) range 4·26-8·44], T1DM (OR range 2·91-9·95) and multiple sclerosis (OR range 6·5-7·99). The latter two and the thyroiditis hypothesis require further investigation to confirm the association. Meta-regression of Crohn's disease studies using DNA detection methods indicated that choice of primers and sampling frame (e.g. general population vs. hospital-based sample) explained a significant proportion of heterogeneity. Other epidemiological studies demonstrated a lack of association between high-risk occupations and development of Crohn's disease. Due to knowledge gaps in understanding the role of M. paratuberculosis in the development or progression of human disease, the evidence at present is not strong enough to inform the potential public health impact of M. paratuberculosis exposure.

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“…Moreover, the first ever longitudinally study of MAP implication in CD patients suggested that MAP may be present as a persistent infection in pediatrics, although the study population was very limited [9].…”

Section: Introductionmentioning

confidence: 99%

Fecal Detection of Mycobacterium avium Paratuberculosis Using the IS900 DNA Sequence in Crohn’s Disease and Ulcerative Colitis Patients and Healthy Subjects

et al. 2011

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The possibility to track the MAP presence in human feces represents a new approach to the "MAP hypothesis". Detection of MAP DNA in feces is very common, reaching very high prevalence both in CD and in UC and even in HC. Our findings seem consistent with a high prevalence of MAP asymptomatic infection among the general population and so the possible involvement of MAP in CD pathogenesis could be linked to a specific immune defective response.

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Mycobacterium avium subspecies paratuberculosis in children with early-onset crohnʼs disease

Cited by 14 publications

References 7 publications

Detection of Mycobacterium avium subsp. paratuberculosis in an Egyptian mixed breeding farm and comparative molecular characterisation of isolates from cattle, camels and cats – a case report

Detection of Mycobacterium avium subsp. paratuberculosis in an Egyptian mixed breeding farm and comparative molecular characterisation of isolates from cattle, camels and cats – a case report

The zoonotic potential ofMycobacterium aviumssp.paratuberculosis: a systematic review and meta-analyses of the evidence

Fecal Detection of Mycobacterium avium Paratuberculosis Using the IS900 DNA Sequence in Crohn’s Disease and Ulcerative Colitis Patients and Healthy Subjects

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