Mycobacterium baemophilum Infection in AIDS

Lerner, Chester W.; Safdar, Amar; Coppel, Suzanne

doi:10.1097/00019048-199505000-00023

Cited by 8 publications

(2 citation statements)

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“…Cutaneous infections with potentially pathogenic mycobacterial species are important for the differential diagnosis of skin lesions in these patients (36,61,93,106). M. haemophilum infections have been reported, especially in patients with lymphoma or HIV and in organ transplant recipients (19,66,81,84,112,153). The clinical spectrum of cutaneous infections caused by M. haemophilum appears to be broad (19,30), varying from localized disease to systemic disease with cutaneous dissemination (49).…”

Section: Cutaneous Manifestationsmentioning

confidence: 99%

Clinical Manifestations, Diagnosis, and Treatment of Mycobacterium haemophilum Infections

et al. 2011

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SUMMARY Mycobacterium haemophilum is a slowly growing acid-fast bacillus (AFB) belonging to the group of nontuberculous mycobacteria (NTM) frequently found in environmental habitats, which can colonize and occasionally infect humans and animals. Several findings suggest that water reservoirs are a likely source of M. haemophilum infections. M. haemophilum causes mainly ulcerating skin infections and arthritis in persons who are severely immunocompromised. Disseminated and pulmonary infections occasionally occur. The second at-risk group is otherwise healthy children, who typically develop cervical and perihilar lymphadenitis. A full diagnostic regimen for the optimal detection of M. haemophilum includes acid-fast staining, culturing at two temperatures with iron-supplemented media, and molecular detection. The most preferable molecular assay is a real-time PCR targeting an M. haemophilum -specific internal transcribed spacer (ITS), but another approach is the application of a generic PCR for a mycobacterium-specific fragment with subsequent sequencing to identify M. haemophilum . No standard treatment guidelines are available, but published literature agrees that immunocompromised patients should be treated with multiple antibiotics, tailored to the disease presentation and underlying degree of immune suppression. The outcome of M. haemophilum cervicofacial lymphadenitis in immunocompetent patients favors surgical intervention rather than antibiotic treatment.

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Section: Cutaneous Manifestationsmentioning

confidence: 99%

Clinical Manifestations, Diagnosis, and Treatment of Mycobacterium haemophilum Infections

et al. 2011

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“…Patients who have colonization of their respiratory and gastrointestinal tracts are at higher risk of developing disseminated disease (102). Of the infections caused by other organisms, M. kansasii has been reported most frequently; however, other NTM, including M. scrofulaceum, M. gordonae, M. haemophilum, M. genavense, M. celatum, M. conspicuum, M. xenopi, M. fortuitum, M. marinum, M. malmoense, and M. simiae, have also been described as a cause of pulmonary or disseminated NTM disease in AIDS (20,(160)(161)(162)(163)(164)(165)(166)(167)(168)(169). Disseminated disease due to NTM in persons with HIV infections occurs only in patients who are severely immunocompromised, as evidenced by very low CD4 ϩ T-cell counts (20,(154)(155)(156)(157).…”

Section: Disseminated Diseasementioning

confidence: 99%

Metabolomic Insights into Tuberculosis: Machine Learning Approaches for Biomarker Identification

2023

IJMCB

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The lung parenchyma is largely impacted by the infectious condition known as pulmonary tuberculosis (pulmonary TB) when the immune system creates a wall around the germs in the lungs, a tiny, hard bulge known as a tubercle develops, earning the disease the name tuberculosis. Although the majority of TB germs target the lungs, they can also harm other bodily organs. The identification of TB biomarkers, which are crucial for diagnosis, treatment monitoring, risk analysis, and prognosis, has been the subject of extensive research. Differences in metabolites between normal cells and tuberculosis are considered to be able to support the diagnosis of tuberculosis. Metabolite data was taken from the Metabolomic workbench and further identification and prediction were carried out in silico. A total of 44 samples found 69 metabolites which were then carried out further analysis. Found as many as 5 metabolites that play an important role in tuberculosis. Of the 5 metabolites, 2 candidate biomarkers were found which are known to have potential as biomarkers. The candidate biomarkers for these metabolites are trans-3-methyluric acid and nicotinic acid. However, this simulation needs further testing to obtain more accurate biomarkers and support the diagnosis.

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Nontuberculous Mycobacterial Infections

Safdar

2011

Principles and Practice of Cancer Infectious Diseases

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Mycobacterium baemophilum Infection in AIDS

Cited by 8 publications

References 0 publications

Clinical Manifestations, Diagnosis, and Treatment of Mycobacterium haemophilum Infections

Clinical Manifestations, Diagnosis, and Treatment of Mycobacterium haemophilum Infections

Metabolomic Insights into Tuberculosis: Machine Learning Approaches for Biomarker Identification

Nontuberculous Mycobacterial Infections

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