Mycobacterium Bovis Infection in Animals and Humans

Thoen, Charles O.; Steele, James H.; Gilsdorf, Michael J.

doi:10.1002/9780470344538

Cited by 95 publications

(63 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The many factors, which have maintained TB in the world today, include (often in combination) poverty (Bhatti et al, 1995), poor diet, TB-contaminated foods [e. g., see Harris et al (2007), overcrowding (Elender et al, 1998), specific occupations such as working with animals (Thoen and Steele, 1995), being in prison (Balinska, 2000), increased mobility through travel (business and pleasure- Driver et al, 1994) and migration (from troubled parts of the world- Bhatia et al, 2001)], the presence of the HIV, age (Johnston, 1995), sex (Hudelson, 1996), and ethnicity (Newport and Levin, 1999), concepts of TB occurrence and access to health education and care (e.g. see Foster, 1999), treatment compliance (Farmer, 1999), and multiple drug resistance.…”

Section: Mycobacterial Diseases: the Historical Epidemiological Andmentioning

confidence: 99%

Tuberculosis and leprosy in perspective

Stone

Wilbur

Buikstra

et al. 2009

American J Phys Anthropol

View full text Add to dashboard Cite

Two of humankind's most socially and psychologically devastating diseases, tuberculosis and leprosy, have been the subject of intensive paleopathological research due to their antiquity, a presumed association with human settlement and subsistence patterns, and their propensity to leave characteristic lesions on skeletal and mummified remains. Despite a long history of medical research and the development of effective chemotherapy, these diseases remain global health threats even in the 21st century, and as such, their causative agents Mycobacterium tuberculosis and M. leprae, respectively, have recently been the subject of molecular genetics research. The new genome-level data for several mycobacterial species have informed extensive phylogenetic analyses that call into question previously accepted theories concerning the origins and antiquity of these diseases. Of special note is the fact that all new models are in broad agreement that human TB predated that in other animals, including cattle and other domesticates, and that this disease originated at least 35,000 years ago and probably closer to 2.6 million years ago. In this work, we review current phylogenetic and biogeographic models derived from molecular biology and explore their implications for the global development of TB and leprosy, past and present. In so doing, we also briefly review the skeletal evidence for TB and leprosy, explore the current status of these pathogens, critically consider current methods for identifying ancient mycobacterial DNA, and evaluate coevolutionary models. Yrbk Phys At the close of the first decade of the 21st century, a number of factors converge to make a review of mycobacterial disease timely. The first of these is the re-emergence of human tuberculosis (TB) in epidemic proportions on a global scale. As emphasized in the section on Mycobacterial diseases: The Historical, Epidemiological, and Ecological Context Section, by the mid-point of the 20th century the disease was thought to be conquerable and by the 1980s, conquered. How wrong these predictions were! TB, termed ''the white plague'' during the 19th century, has a very long history as a health burden to humankind, which continues today. A thorough knowledge of the coevolution of humans and pathogenic mycobacteria may inform development of treatment and prevention methods.A second important factor making a review of mycobacterial disease timely involves the emergence of new techniques in molecular biology. The development of the polymerase chain reaction (PCR) method for amplifying DNA, advancements in sequencing technology, as well as the availability of mycobacterial genome sequences have revolutionized our knowledge of contemporary mycobacterial genetic variation. These advances permit scientists not only to explore global patterning within species, but also to make phylogenetic inferences and understand the evolutionary relationships between mycobacterial strains. In turn, molecular biologists and anthropologists have used this technology to identify...

show abstract

Section: Mycobacterial Diseases: the Historical Epidemiological Andmentioning

confidence: 99%

Tuberculosis and leprosy in perspective

Stone

Wilbur

Buikstra

et al. 2009

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…It is characterized by progressive development of granulomatous lesions in affected tissues and organs (Shitaye et al, 2006;Theon et al, 2006). TB is caused by slow growing non-pigmented bacilli that belong to the Mycobacterium tuberculosis complex (MTBC).…”

Section: ■ Introductionmentioning

confidence: 99%

Mycobacterial infections in carcasses of ruminants slaughtered at the two slaughterhouses of Kassala, Sudan

Shuaib¹,

Niemann²,

Khalil³

et al. 2018

Rev. Elev. Med. Vet. Pays Trop.

View full text Add to dashboard Cite

SummaryTuberculosis (TB) is a chronic bacterial disease of humans and animals. It is characterized by the progressive development of specific granulomatous lesions in affected organs. Human TB is endemic in EasternSudan. However, knowledge on the epidemiology of TB in ruminants is scarce. In a six-month study from June to November 2014, a total of 2304 carcasses of cattle, sheep, goats and camels slaughtered at the East and West Gaash slaughterhouses of Kassala were inspected to investigate TB prevalence. Only 0.1% (n = 2) of the carcasses had suspicious TB lesions. These lesions were solely found in carcasses of sheep, in the liver, lungs, and peritoneal cavity. The samples collected from the lesions were investigated for the presence of mycobacteria, which were found in one of the two carcasses. The grown bacteria were subjected to a line probe assay (GenoType Mycobacterium CM), and to 16S rDNA and ITS gene sequencing, and whole genome sequencing (WGS). However, none of these methods identified this isolate as a valid Mycobacterium species. Nevertheless, 16S sequence allocated this isolate to slow growing mycobacteria. Neither Mycobacterium bovis nor M. caprae nor M. tuberculosis were found in the collected granulomatous lesions. In conclusion, the overall prevalence of TB-suggestive lesions in ruminants in Kassala was very low. Extended studies combining the use of a tuberculin skin test and slaughterhouse-based investigations should be adopted for TB surveillance in ruminants in Sudan.■ How to quote this article: Shuaib Y.A., Niemann S., Khalil E.A.G., Schaible U., Wieler L.H., Bakheit M.A., Mohamed-Noor S.E., Abdalla M.A., Richter E., 2017. Mycobacterial infections in carcasses of ruminants slaughtered at the two slaughterhouses of Kassala, Sudan. Rev. Elev. Med. Vet. Pays Trop.,

show abstract

“…Tuberculosis (TB), caused by organisms within the Mycobacterium tuberculosis complex (MTC), is a serious chronic infection of humans and animals world-wide (Thoen et al, 2006). Classical members of the MTC are M. tuberculosis, M. bovis, M. bovis BCG, M. africanum and M. microti, which are closely related from a taxonomic point of view (Aranaz et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Zoo animals may originate from the countries with a high prevalence of TB among humans and animals. Moreover, animals in captive settings are believed to be more susceptible to TB than free-living animals (Thoen et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…In our opinion, one or more of the six bison should be regarded as the source of infection while the dromedary camel (case 1) was most probably a spill-over host. Bison are closely related to cattle (both genera belong to the subfamily Bovinae), which are the natural hosts of the causative agent of bovine TB (Thoen et al, 2006). Thus bison were more likely to develop the chronic subclinical form of the disease, which may take years until the manifestation of the clinical signs.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Outbreak of Tuberculosis Caused by Mycobacterium caprae in a Zoological Garden

Pate¹,

Švara²,

Gombač³

et al. 2006

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

In the autumn of 2004, tuberculosis caused by Mycobacterium caprae occurred in a zoo in Slovenia. A dromedary camel (Camelus dromedarius) was killed after a history of progressive emaciation. Necropsy findings indicated disseminated tuberculosis, which was confirmed by cultivation of M. caprae. Consequently, a tuberculin skin test was performed in all epidemiologically linked animals and another dromedary camel and six bison (Bison bison) were positive and killed. Mycobacterium caprae was isolated from two bison while M. scrofulaceum and Mycobacterium spp. were found in two other bison, respectively. The second dromedary camel was found to be negative for mycobacteria under both microscopic and culture tests. The isolates were investigated with commercial identification kits, IS6110 PCR, IS6110 restriction fragment length polymorphism analysis, spoligotyping and mycobacterial interspersed repetitive units typing. Genotyping results revealed that the dromedary camel and the two bison were infected by the same M. caprae.

show abstract

Mycobacterium Bovis Infection in Animals and Humans

Cited by 95 publications

References 0 publications

Tuberculosis and leprosy in perspective

Tuberculosis and leprosy in perspective

Mycobacterial infections in carcasses of ruminants slaughtered at the two slaughterhouses of Kassala, Sudan

Outbreak of Tuberculosis Caused by Mycobacterium caprae in a Zoological Garden

Contact Info

Product

Resources

About