Mycobacterium Chelonae Infections Associated With Bee Venom Acupuncture

Cho, Sun Young; Peck, Kyong Ran; Kim, Jung Ok; Ha, Young Eun; Kang, Cheol-In; Chung, Doo Ryeon; Lee, Nam Yong; Song, Jae–Hoon

doi:10.1093/cid/cit753

Cited by 13 publications

(7 citation statements)

References 11 publications

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“…A combination antimicrobial therapy is however recommended to avoid development of mutational resistance. Moxifloxacin has proven to be a successful supplement to clarithromycin in this case as well as in other case reports 24. A minimum of 4 months is necessary to treat skin or soft tissue infection.…”

Section: Discussionsupporting

confidence: 59%

“…While M. fortuitum causes infection primarily by direct inoculation, M. chelonae often causes infection in immunosuppressed patients. M. chelonae infection should be considered in patients with chronic soft tissue infections non-responsive to commonly used antimicrobial therapies 24. The source of M. chelonae infection is usually not identified due to the ubiquitous presence in the environment.…”

Section: Discussionmentioning

confidence: 99%

“…35 According to ATS guidelines, M. chelonae is susceptible to clarithromycin (100%) and tobramycin (100%), linezolid (90%), amikacin (50%), doxycycline (25%) and ciprofloxacin (20%) 6. Clarithromycin is the drug of choice 24 36–38. A combination antimicrobial therapy is however recommended to avoid development of mutational resistance.…”

Section: Discussionmentioning

confidence: 99%

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Mycobacterium chelonaehand infection after steroid injection in a patient with rheumatoid arthritis receiving long-term linezolid therapy

Olesen

Wang

Wejse³

2017

BMJ Case Reports

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A 66-year-old multimorbid man with rheumatoid arthritis developed an infection after a steroid injection in the hand. Mycobacterium chelonae was cultured 1-month after presentation. In the mean time, his third finger had been amputated. Further treatment was based on preliminary susceptibility testing and the American Thoracic Society guidelines. No regression of the infection was observed before the addition of linezolid (600 mg×1/day) to a combination antimicrobial therapy also consisting of clarithromycin (500 mg×2/day) and moxifloxacin (400 mg×1/day), even though two methods of susceptibility testing, the E-test and broth microdilution, had shown susceptibility to other antimicrobial drugs. The healing was complete 12 months after presentation. There were no serious side effects observed with the use of linezolid in reduced dosage of 600 mg×1/day for a duration of 9 months.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Mycobacterium chelonaehand infection after steroid injection in a patient with rheumatoid arthritis receiving long-term linezolid therapy

Olesen

Wang

Wejse³

2017

BMJ Case Reports

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“…Although most species are nonpathogenic, Thomson et al found pathogenic NTM species in large urban water distribution systems in Australia [ 4 ]. Human NTM diseases (e.g., pulmonary diseases, lymphadenitis, skin and soft tissue infections, and disseminated diseases) are believed to result from environmental exposure, trauma, and surgical or cosmetic procedures [ 5 ]. In 2019, Hung et al reported a cluster of patients with postoperative M. abscessus endophthalmitis [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus

Tseng

Sun

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Mycobacterium abscessus infections are notoriously difficult to be treated and newer treatment options are required. Coptis chinensis (C. chinensis) and its main compound berberine are frequently used to treat bacterial and viral infections. In this study, the susceptibility of M. abscessus to C. chinensis extract and berberine was assessed by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) evaluation. The effects of C. chinensis and berberine on biofilm formation and antibiotic susceptibility in M. abscessus were observed. C. chinensis at concentrations of MIC (1.5 mg/mL) and 2 × MIC (3.0 mg/mL) and berberine at ½ × MIC (0.125 mg/mL) demonstrated a strong inhibition of biofilm formation. Concentration of C. chinensis at ½ × MIC resulted in a significant reduction in MICs of trimethoprim/sulfamethoxazole (TMP/SXT), clarithromycin (CLA), and linezolid (LZD). Similarly, ½ × MIC berberine had a significant effect on the MIC reductions of nine antibiotics including TMP/SXT, CLA, and LZD. Notably, the resistance level MIC of LZD against M. abscessus was reversed to a susceptible level by treatment with either C. chinensis or berberine. Therefore, C. chinensis and berberine have the potential to produce a synergistic antimycobacterial effect, reduce biofilm formation, and decrease antibacterial resistance to LZD in M. abscessus.

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“…Infections with non-tuberculous mycobacteria have been described increasingly, especially in immunocompromised patients and as iatrogenic infections in immunocompetent patients, causing a variety of local and disseminated disease. RGM in particular can cause local skin and soft tissue infections (SSTI) and have also been described in outbreak and pseudo-outbreak settings involving infections after surgery or other invasive procedures [ 1 ]-[ 3 ]. Here, we describe a case from the Hospital of Tropical Diseases in Ho Chi Minh City, Vietnam of M. fortuitum infection of the skin and soft tissues covering several joints after injection of traditional Vietnamese medicine to relieve joint pain.…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium fortuitum skin infections after subcutaneous injections with Vietnamese traditional medicine: a case report

et al. 2014

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Background: Iatrogenic skin and soft tissue infections by rapidly growing mycobacteria are described with increasing frequency, especially among immunocompromised patients. Case presentation: Here, we present an immunocompetent patient with extensive Mycobacterium fortuitum skin and soft tissue infections after subcutaneous injections to relieve joint pains by a Vietnamese traditional medicine practitioner. Moreover, we present dilemmas faced in less resourceful settings, influencing patient management. Conclusion: This case illustrates the pathogenic potential of rapid growing mycobacteria in medical or non-medical skin penetrating procedures, their world-wide distribution and demonstrates the dilemmas faced in settings with fewer resources.

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Mycobacterium Chelonae Infections Associated With Bee Venom Acupuncture

Abstract: We report 3 cases of Mycobacterium chelonae infections after bee venom acupuncture. All were treated with antibiotics and surgery. Mycobacterium chelonae infections should be included in the differential diagnosis of chronic skin and soft tissue infections following bee venom acupuncture.

Cited by 13 publications

References 11 publications

Mycobacterium chelonaehand infection after steroid injection in a patient with rheumatoid arthritis receiving long-term linezolid therapy

Mycobacterium chelonaehand infection after steroid injection in a patient with rheumatoid arthritis receiving long-term linezolid therapy

Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus

Mycobacterium fortuitum skin infections after subcutaneous injections with Vietnamese traditional medicine: a case report

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