Mycobacterium fortuitum empyema associated with an indwelling pleural catheter: Case report and review of the literature

Blair, Paul W; Moshgriz, Mahdi; Siegel, Marc

doi:10.1016/j.jiac.2016.08.016

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…However, no consensus treatment regimen has been established for extra-pulmonary NTM diseases ( 2 ), and poor outcomes of patients with M. abscessus disease have been reported ( 19 ). Similar to our patient, anti-tuberculosis regimens were often used initially in patients with NTM pleurisy including M. abscessus , but RGMs are reported to show no susceptibility to treatment with these first-line agents ( 10 , 12 ). A few reports have shown the clinical effect of combined treatment with CAM, EB, and RFP on patients with pulmonary NTM infection ( 20 , 21 ), and improvements in the pleural effusion and high-grade fever were achieved by treatment with first-line anti-tuberculosis medications in our case.…”

Section: Discussionsupporting

confidence: 74%

Pleurisy Caused by <i>Mycobacterium abscessus</i> in a Young Patient with Dermatomyositis: A Case Report and Brief Review of the Literature

et al. 2018

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M. abscessus is a rapidly growing mycobacteria (RGM) and is the most common cause of pulmonary RGM infection. M. abscessus pleurisy is extremely rare. We herein report the case of a young patient with M. abscessus pleurisy without any lung lesions. A laboratory analysis of the pleural effusion revealed lymphocyte predominance and increased adenosine deaminase, similar to the findings observed in tuberculous pleurisy. The patient was initially treated for tuberculous pleurisy, which resulted in the partial improvement of the patient's symptoms and pleural effusion. M. abscessus pleurisy should be considered, especially in immunocompromised individuals, even in the absence of pulmonary involvement.

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Section: Discussionsupporting

confidence: 74%

Pleurisy Caused by <i>Mycobacterium abscessus</i> in a Young Patient with Dermatomyositis: A Case Report and Brief Review of the Literature

et al. 2018

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“…M. fortuitum , which belongs to the rapidly growing mycobacteria (RGM), is a well-known cause of skin, soft tissue, post-surgical wound and catheter-related infections [7, 15]. Pulmonary infection by this species is relatively rare; however, its incidence increases in patients with gastro-oesophageal disorders such as gastrectomy or reflux disease [6], which is also a risk factor for beriberi [16].…”

Section: Discussionmentioning

confidence: 99%

“…More specifically for M. fortuitum , gastro-oesophageal disorders such as gastrectomy or reflux disease have been reported as risk factors for pulmonary infection [6]. Despite the fact that M. fortuitum is occasionally cultured from sputum samples, it rarely causes pulmonary disease [7]. However, in this case, the patient presented many risk factors.…”

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confidence: 99%

A rare pulmonary pathology complicated with an unusual condition

Kotoulas

Manika

Pilianidis

et al. 2019

Breathe

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A 73-year-old male presented to the emergency department complaining about fatigue, night sweats, lack of appetite and weight loss for the past 2 months. His baseline weight was 47 kg and his height was 1.78 m (body mass index of 14.83 kg·m −2 ), while at presentation he weighed 39 kg. From his history, he underwent gastrectomy 31 years ago for stomach cancer. He was a smoker (55 pack-years), with no history of alcohol consumption or any other known pathological condition. Despite his gastrectomy, he did not suffer from symptoms suggesting reflux disease. 2 years ago, his daughter suffered from pulmonary tuberculosis, but he was not checked at that time with either a Mantoux test or chest radiograph. Physical examination revealed crackles in both lungs. His heart rate and blood pressure were normal. Because of his gastrectomy, he was on treatment with B12 and folic acid supplements and on presentation he did not reveal megaloblastic anaemia. From his laboratory examinations, his white blood cells were normal (9780 cells·μL −1 (68.4% neutrophils, 21.7% lymphocytes)) while his C-reactive protein was elevated (8.87 mg·dL −1 ). Despite his obviously impaired nutritional status his serum albumin was slightly above the lower normal level (3.67 g·dL −1 ). His chest computed tomography (CT) revealed infiltrations bilaterally, signs of incipient pulmonary fibrosis with thickened interlobular septa, centrilobular nodules and loss of volume of the left lower lobe (figure 1). His blood gas analysis revealed hypoxaemia; therefore, he was admitted to hospital and initiated intravenous antibiotic treatment with ampicillin/sulbactam plus azithromycin.

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“…4 Rapid growing mycobacteria (RGM) can form biofilms drastically affecting immunocompromised hosts, and the infection progression are challenging to control due to multi-drug resistance profiles against different antibiotics, 5 such as clarithromycin, imipenem, 6 rifampicin, isoniazid, ethambutol, pyrazinamide, 7 cefoxitin, and doxycycline. 8 Mycobacterium fortuitum is mainly present in skin, soft tissue and catheter associated infections, 9 while Mycobacterium abscessus noticeably accounts for pulmonary infections 10 and Mycobacterium massiliense for post-surgical ones. 11 Considering the reduced introduction of novel antibiotics in the market and the increasing resistance to the commonly used in mycobacterial infections, the urge for new antimycobacterial agents is a reality.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of New Eugenol-Derived 1,2,3-Triazoles as Antimycobacterial Agents

Santos

Coelho

Elias

et al. 2019

J. Braz. Chem. Soc.

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Eugenol has diverse biological properties including antimycobacterial activity, and the triazole ring is an important heterocycle in antimycobacterial compounds. Therefore, this research aimed to synthesize novel eugenol-derived 1,2,3-triazole as antimycobacterial agents with interesting cytotoxic profile and pharmacological assets. Sixteen compounds were obtained and characterized by nuclear magnetic resonance (NMR), infrared (IR), and high-resolution mass spectrometry (HRMS). Among them, the best growth inhibition properties from a microdilution assay were observed for three derivatives: a benzylic ether (minimum inhibitory concentration (MIC) = 48.89 µM) against Mycobacterium abscessus (ATCC 19977), an O-galactosyde (MIC = 31.76 µM) against Mycobacterium massiliense (ATCC 48898) and a sulfonate (MIC = 88.64 µM) against Mycobacterium fortuitum (ATCC 6841). They can form biofilms, and the infection progression is challenging to control due to multi-drug resistance profiles against diverse antibiotics. In conclusion, the above-mentioned compounds represent starting points in the search of bioactive molecules against mycobacteria with low cytotoxicity and better pharmacological profiles.

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Mycobacterium fortuitum empyema associated with an indwelling pleural catheter: Case report and review of the literature

Cited by 8 publications

References 14 publications

Pleurisy Caused by <i>Mycobacterium abscessus</i> in a Young Patient with Dermatomyositis: A Case Report and Brief Review of the Literature

Pleurisy Caused by <i>Mycobacterium abscessus</i> in a Young Patient with Dermatomyositis: A Case Report and Brief Review of the Literature

A rare pulmonary pathology complicated with an unusual condition

Synthesis and Biological Evaluation of New Eugenol-Derived 1,2,3-Triazoles as Antimycobacterial Agents

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