Mycobacterium fortuitum pulmonary infection associated with an antigen-selective defect in cellular immunity

Metcalf, John F.; John, Joseph F.; Wilson, Gregory B.; Fudenberg, H. Hugh; Harley, Russell A.

doi:10.1016/0002-9343(81)90186-8

Cited by 21 publications

(6 citation statements)

References 38 publications

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“…A rare case of pulmonary infection due to M. fortuitum associated with an antigen-selective defect in cell-mediated immunity to the organism was also described (244). A defect in cellular immunity to purified protein derivative (PPD) from M. fortuitum was shown to be antigen selective, evidenced by a normal response to PPD from M. tuberculosis and several other antigens accompanying extended M. fortuitum infection (244).…”

Section: Treatment Of Nontuberculous Mycobacterial Infections Pulmonarymentioning

confidence: 99%

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Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

2012

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SUMMARY Within the past 10 years, treatment and diagnostic guidelines for nontuberculous mycobacteria have been recommended by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA). Moreover, the Clinical and Laboratory Standards Institute (CLSI) has published and recently (in 2011) updated recommendations including suggested antimicrobial and susceptibility breakpoints. The CLSI has also recommended the broth microdilution method as the gold standard for laboratories performing antimicrobial susceptibility testing of nontuberculous mycobacteria. This article reviews the laboratory, diagnostic, and treatment guidelines together with established and probable drug resistance mechanisms of the nontuberculous mycobacteria.

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Section: Treatment Of Nontuberculous Mycobacterial Infections Pulmonarymentioning

confidence: 99%

“…A defect in cellular immunity to purified protein derivative (PPD) from M. fortuitum was shown to be antigen selective, evidenced by a normal response to PPD from M. tuberculosis and several other antigens accompanying extended M. fortuitum infection (244).…”

Section: Treatment Of Nontuberculous Mycobacterial Infections Pulmonarymentioning

confidence: 99%

Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

2012

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“…The M. chelonae-abscessus group has been involved in several health care-associated disease outbreaks including post-cardiac surgery sternal wound infections and vein graft site infections (87). Other outbreaks of M. chelonae-abscessus group infection have involved plastic surgery (52,146), hemodialysis, and miscellaneous outbreaks including wound infections following laparoscopy, liposuction (107), and post-tympanostomy tube placement (98). Additionally, postinjection abscess outbreaks following the use of multidose vials (15,62,129) or contaminated biologicals (30,33,57,183) also have been reported.…”

Section: Chelonae-abscessus Groupmentioning

confidence: 99%

“…Sporadic localized wound infections following medical or surgical procedures including needle injections can occur with M. chelonae but are rare compared to infections with M. fortuitum and M. abscessus. Health care-associated outbreaks due to M. chelonae are also rare and have been observed only following injection with contaminated syringes or needles, the implantation of contaminated porcine heart valves (55,79,189), and, recently, the use of liposuction (107). In this last outbreak, the organism was recovered from tap water connected to the suction cannulas.…”

Section: Chelonae-abscessus Groupmentioning

confidence: 99%

“…The RGM have been recognized for over 20 years as causative agents of sporadic nosocomial or health care-associated infections including disease that involves renal dialysis; punch biopsy surgery; augmentation mammaplasty; other forms of plastic surgery including face-lifts and liposuction; sternal wound infections following cardiac surgery; and postinjection abscesses (12,22,38,57,97,107,183,198). In one series of 44 postsurgical RGM infections, 31 cases involved M. fortuitum and 13 cases involved the M. chelonae-abscessus group (203).…”

Section: Postsurgical Wound Infectionsmentioning

confidence: 99%

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Clinical and Taxonomic Status of Pathogenic Nonpigmented or Late-Pigmenting Rapidly Growing Mycobacteria

2002

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The history, taxonomy, geographic distribution, clinical disease, and therapy of the pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria (RGM) are reviewed. Community-acquired disease and health care-associated disease are highlighted for each species. The latter grouping includes health care-associated outbreaks and pseudo-outbreaks as well as sporadic disease cases. Treatment recommendations for each species and type of disease are also described. Special emphasis is on the Mycobacterium fortuitum group, including M. fortuitum, M. peregrinum, and the unnamed third biovariant complex with its recent taxonomic changes and newly recognized species (including M. septicum, M. mageritense, and proposed species M. houstonense and M. bonickei). The clinical and taxonomic status of M. chelonae, M. abscessus, and M. mucogenicum is also detailed, along with that of the closely related new species, M. immunogenum. Additionally, newly recognized species, M. wolinskyi and M. goodii, as well as M. smegmatis sensu stricto, are included in a discussion of the M. smegmatis group. Laboratory diagnosis of RGM using phenotypic methods such as biochemical testing and high-performance liquid chromatography and molecular methods of diagnosis are also discussed. The latter includes PCR-restriction fragment length polymorphism analysis, hybridization, ribotyping, and sequence analysis. Susceptibility testing and antibiotic susceptibility patterns of the RGM are also annotated, along with the current recommendations from the National Committee for Clinical Laboratory Standards (NCCLS) for mycobacterial susceptibility testing

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Sarcoidlike Manifestations of Histoplasmosis

Wheat

French²,

Wass³

1989

Arch Intern Med

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Mycobacterium fortuitum pulmonary infection associated with an antigen-selective defect in cellular immunity

Cited by 21 publications

References 38 publications

Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

Clinical and Taxonomic Status of Pathogenic Nonpigmented or Late-Pigmenting Rapidly Growing Mycobacteria

Sarcoidlike Manifestations of Histoplasmosis

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