Mycobacterium tuberculosis aortic graft infection with recurrent hemoptysis: a case report

Clerc, Olivier; Jaton, Katia; Prod’hom, Guy; Segesser, Ludwig von; Greloz, Vincent; Greub, Gilbert

doi:10.1186/1752-1947-2-233

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Bartonella henselae [67] Francisella tularensis [68,69] M. tuberculosis complex [70] Toxoplasma gondii Perform also a serology if infectious mononucleosis is suspected EBV Systemic (immunosuppressed patients) Adenovirus [71] BK virus [72] CMV [72] EBV [73,74] HHV-6 [75] HHV-8 [76] Parvovirus B19 Endocarditis/systemic infection Bartonella henselae/quintana [77] Coxiella burnetii May also be performed on sera or EDTA blood. Serology is recommended since PCR is generally becoming negative at the time of seroconversion [26,78] Mycoplasma hominis [79] Rickettsiae sp./group typhus [33]…”

Section: Adenopathiesmentioning

confidence: 99%

Ten Years of R&D and Full Automation in Molecular Diagnosis

et al. 2016

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A 10-year experience of our automated molecular diagnostic platform that carries out 91 different real-time PCR is described. Progresses and future perspectives in molecular diagnostic microbiology are reviewed: why automation is important; how our platform was implemented; how homemade PCRs were developed; the advantages/disadvantages of homemade PCRs, including the critical aspects of troubleshooting and the need to further reduce the turnaround time for specific samples, at least for defined clinical settings such as emergencies. The future of molecular diagnosis depends on automation, and in a novel perspective, it is time now to fully acknowledge the true contribution of molecular diagnostic and to reconsider the indication for PCR, by also using these tests as first-line assays.

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Section: Adenopathiesmentioning

confidence: 99%

Ten Years of R&D and Full Automation in Molecular Diagnosis

et al. 2016

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“…and Listeria spp. as well as Mycobacterium tuberculosis and nontuberculosis Mycobacteria have been reported in association with both intravascular and extravascular foreign body infections [105][106][107][108][109][110][111][112]. However, the host response to these bacteria is different.…”

Section: Intracellular Persistence Of Bacteria In Implant-associated mentioning

confidence: 99%

Pathogenesis of implant-associated infection: the role of the host

2011

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Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which can be designated as biocompatibility. The interaction of the device with adjacent granulocytes and complement not only induces various degrees of inflammation but also impairs local microbial clearance. Foreign surfaces are a preferred target for bacterial adherence. While adhering bacteria are highly resistant to the bactericidal activity of phagocytes, they are also resistant to most antimicrobial agents. Certain bacteria may reside within host cells, and hence, evade host defense mechanisms by persisting intracellularly around implants. Nanotechnology minimizes clotting activation and bacterial adhesion by intravascular devices. Furthermore, surface coating with appropriate substances favorably influences biocompatibility as well as susceptibility to infection. In the future, "Microsystems Technology" deployed as intelligent device may decrease the risk of implant failure due to infection.

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Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections

Azad,

Patel

2024

Clin Microbiol Rev

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SUMMARY Implant-associated infections (IAIs) pose serious threats to patients and can be associated with significant morbidity and mortality. These infections may be difficult to diagnose due, in part, to biofilm formation on device surfaces, and because even when microbes are found, their clinical significance may be unclear. Despite recent advances in laboratory testing, IAIs remain a diagnostic challenge. From a therapeutic standpoint, many IAIs currently require device removal and prolonged courses of antimicrobial therapy to effect a cure. Therefore, making an accurate diagnosis, defining both the presence of infection and the involved microorganisms, is paramount. The sensitivity of standard microbial culture for IAI diagnosis varies depending on the type of IAI, the specimen analyzed, and the culture technique(s) used. Although IAI-specific culture-based diagnostics have been described, the challenge of culture-negative IAIs remains. Given this, molecular assays, including both nucleic acid amplification tests and next-generation sequencing-based assays, have been used. In this review, an overview of these challenging infections is presented, as well as an approach to their diagnosis from a microbiologic perspective.

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Mycobacterium tuberculosis aortic graft infection with recurrent hemoptysis: a case report

Cited by 4 publications

References 12 publications

Ten Years of R&D and Full Automation in Molecular Diagnosis

Ten Years of R&D and Full Automation in Molecular Diagnosis

Pathogenesis of implant-associated infection: the role of the host

Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections

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