Mycobacterium tuberculosis Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Assefa, Muluneh; Girmay, Getu

doi:10.2147/itt.s455744

ITT

2024

DOI: 10.2147/itt.s455744

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Mycobacterium tuberculosis Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Muluneh Assefa,

Getu Girmay

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2024

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Antibiotic Resistance in Mycobacteria

Zeng,

Tan,

Gao

2024

Mycobacteria - Comparative Genomics, Biomarker Identification, Laboratory Diagnosis and Clinical Treatment [Working Title]

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Mycobacterium infection caused by Mycobacterium tuberculosis (MTB) and non-tuberculosis mycobacterium (NTM) presents a serious threat to global health, mainly due to a protracted treatment regimen involving a combination of drugs. Antibiotic resistance in mycobacterium is mainly due to a frequent gene mutation that encodes antibiotic resistance. There are also several additional unique features of drug resistance, such as chromosomal mutation, efflux pumps, bacterial heterogeneity, slow metabolism, biofilm formation, antibiotic degradation or modification, target modification, and host microenvironment. In this chapter, we discuss the traditional mechanisms of drug resistance in mycobacterium, newer understandings, and the shaping of unconventional approaches to target both the emergence and treatment of drug resistance in mycobacterium.

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Antibiotic Resistance in Mycobacteria

Zeng,

Tan,

Gao

2024

Mycobacteria - Comparative Genomics, Biomarker Identification, Laboratory Diagnosis and Clinical Treatment [Working Title]

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show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Mycobacterium tuberculosis Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Cited by 1 publication

References 69 publications

Antibiotic Resistance in Mycobacteria

Antibiotic Resistance in Mycobacteria

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