Mycobacterium tuberculosis complex: Detection and patterns of resistance to the first line anti-TB drugs at the King Abdulaziz University Hospital, Saudi Arabia

Abstract

Background: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Continued surveillance of drug susceptibility helps determining proper treatment regimen. This study aimed to investigate occurrence, patterns of anti-tuberculosis drug-susceptibility at the King Abdulaziz University Hospital (KAUH), Jeddah, KSA.

Prevalence and outcome of isoniazid-monoresistant tuberculosis at a university hospital in Saudi Arabia

“…5 A study at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, focused on investigating the trends of resistance to the current standard anti-TB regimen and revealed the monoresistance proportion to INH was 1%, to PZN was 11.9%, and to RIF was 2%. 6 Furthermore, RIF monoresistance is rare worldwide and is usually associated with MDR TB. 7 Recent literature has shown INH monoresistance increased the likelihood of failure in treatments and relapse in patients treated with first-line anti-TB regimens.…”

“…https://smj.org.sa Saudi Med J 2021; Vol. 42(6) Isoniazid-resistant tuberculosis ... Binkhamis et al…”