Mycobacterium tuberculosis concealed by enterococcal sacroiliitis

Chandradevan, Raguraj; Takeda, Hironobu; Lim, Tanna; Patel, Nidhip

doi:10.1016/j.idcr.2020.e00858

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…and Luo et al. observed E. faecalis in both blood cultures and synovial tissue culture from RA patients ( 27 , 28 ). However, other species and phyla have not been reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, Enterococcus faecalis, Yamamoto et al found that hyperimmunization with attenuated E. faecalis as normal gut microbiota could provide an animal model of chronic polyarthritis (26). Chandradevan et al and Luo et al observed E. faecalis in both blood cultures and synovial tissue culture from RA patients (27,28). However, other species and phyla have not been reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

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Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

et al. 2021

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Several studies have investigated the causative role of the microbiome in the development of rheumatoid arthritis (RA), but changes in the gut microbiome in RA patients during drug treatment have been less well studied. Here, we tracked the longitudinal changes in gut bacteria in 22 RA patients who were randomized into two groups and treated with Huayu-Qiangshen-Tongbi formula (HQT) plus methotrexate (MTX) or leflunomide (LEF) plus MTX. There were differences in the gut microbiome between untreated (at baseline) RA patients and healthy controls, with 37 species being more abundant in the RA patients and 21 species (including Clostridium celatum) being less abundant. Regarding the functional analysis, vitamin K2 biosynthesis was associated with RA-enriched bacteria. Additionally, in RA patients, alterations in gut microbial species appeared to be associated with RA-related clinical indicators through changing various gut microbiome functional pathways. The clinical efficacy of the two treatments was further observed to be similar, but the response trends of RA-related clinical indices in the two treatment groups differed. For example, HQT treatment affected the erythrocyte sedimentation rate (ESR), while LEF treatment affected the C-reactive protein (CRP) level. Further, 11 species and 9 metabolic pathways significantly changed over time in the HQT group (including C. celatum, which increased), while only 4 species and 2 metabolic pathways significantly changed over time in the LEF group. In summary, we studied the alterations in the gut microbiome of RA patients being treated with HQT or LEF. The results provide useful information on the role of the gut microbiota in the pathogenesis of RA, and they also provide potentially effective directions for developing new RA treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

et al. 2021

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“…Misdiagnosis was an important factor that delayed treatment in the cases presented above. Importantly, misdiagnosis of rare forms of EPTB occurs in both developing and developed nations [ [17] , [18] , [19] ]. EPTB infection in organs with a high normal burden of bacterial flora, like the colon, can be particularly difficult to diagnose as samples may culture pathogenic bacteria that disguise the mycobacterial tuberculosis infection, delaying diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Mistaken identity: Reporting two cases of rare forms of extrapulmonary tuberculosis in Solomon Islands

Bush,

Fiuramo,

Liligeto

et al. 2024

International Journal of Surgery Case Reports

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“…Isolated tuberculosis of the sacrum is rarely reported in the literature, mostly limited to sporadic cases, with a frequency estimated at for approximately 0.3 to 0.5% of all tuberculosis cases [1][2][3]. Its presenting symptoms are non-specific, with a predominance of vague backpain [4].…”

Section: Case Reportmentioning

confidence: 99%