Mycobacterium tuberculosis infection in systemic lupus erythematosus patients

Hussein, Dahlia A.; Habeeb, Reem A.; El-Azizi, N.O.; El-Deen, Noha Nagi M. Salah; Morad, Caroline S.; Hawwash, Amr Mohammad

doi:10.1016/j.ejr.2017.04.005

Cited by 6 publications

(11 citation statements)

References 31 publications

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“…Among 27 studies, nine were from China, 7,8,11,12,[20][21][22][23][24] and the rest were in various countries 1,[4][5][6]9,[14][15][16][25][26][27][28][29][30][31][32][33][34] (Table 1). Twenty-five studies reported prevalence of TB disease, [4][5][6][7][8][9]11,12,[14][15][16]20,21,[23][24][25][26][27][29][30][31][32][33][34] whereas three studies ...…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…Twenty-five studies reported prevalence of TB disease, [4][5][6][7][8][9]11,12,[14][15][16]20,21,[23][24][25][26][27][29][30][31][32][33][34] whereas three studies reported the prevalence of TB infection. 1,4,28 Ten studies reported the type of immunosuppressive medications in TB disease patients. 6,7,9,11,[14][15][16]25,31,32 Glucocorticoid (GC) treatment was reported in seven studies.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…13 Compared with the previous study, 13 our study included more studies (27 vs 26 studies) reporting TB prevalence with greater number of total participants (47,133 vs 42,063 subjects). We added four new studies 1,25,26,31 and one study had updated study data. 6 We excluded six studies from previous meta-analysis due to no clear SLE diagnosis criteria (four studies), experimental study (one study), and duplication data with smaller sample size (one study).…”

Section: Discussionmentioning

confidence: 99%

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Global tuberculosis disease and infection in systemic lupus erythematosus patients: A systematic review and meta-analysis

Darmawan,

Liman,

Wibowo

et al. 2024

Lupus

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Background Tuberculosis (TB) is one of the most common infections among systemic lupus erythematosus (SLE) patients. We aimed to evaluate the global prevalence of TB infection and disease, its type, and medication risk factors in SLE patients. Methods We searched PubMed, Science Direct, EBSCO, and Web of Science databases from inception to April 30, 2023, and included studies assessing TB among SLE patients. We estimated the prevalence of TB disease (including type of TB disease), TB infection, and SLE medication as TB risk factors. Meta-analysis was performed using Stata 14.2 and Review Manager 5.3. Results Twenty-seven studies met the eligibility criteria. The global prevalence of TB disease was 4% (95% confidence interval (CI): 3–4%, n = 25) and TB infection was 18% (95% CI: 10–26%, n = 3). The pooled prevalence of pulmonary TB, extrapulmonary TB, and disseminated TB were 2% (95% CI: 2–3%, n = 20), 1% (95% CI: 1–2%, n = 17), and 1% (95% CI: 0–1%, n = 6), respectively. The 1-year cumulative glucocorticoid (GC) dose in SLE patients contracting TB was higher than in those without TB, having a mean difference of 2.56 (95% CI: 0.22–4.91, p < .00001, n = 3). The odd ratio of TB was 2.11 (95% CI: 1.01–4.41, p = .05, n = 3) in SLE patients receiving methylprednisolone (MP) pulse therapy as compared to those without MP pulse therapy. Other immunosuppressive agents were not significantly associated with TB. Conclusion TB prevalence in SLE was relatively high and associated with GC. Awareness of TB and lowering GC dose are warranted to alleviate the TB burden in SLE.

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Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Global tuberculosis disease and infection in systemic lupus erythematosus patients: A systematic review and meta-analysis

Darmawan,

Liman,

Wibowo

et al. 2024

Lupus

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“…Th e tuberculin skin test is reader dependent and it can be falsely negative in lupus patients due to immunity dysregulation or previous bacillus Calmette-Guérin vaccine. However, QuantiFERON ® (QIAGEN N.V., Vento, Netherlands) gamma levels are more accurate in this group of patients [27] . Belimumab (Benlysta ® ) (GlaxoSmithKline plc., Brentford, London, United Kingdom) is a targeted, human monoclonal antibody that binds to soluble B lymphocyte stimulator (BLyS).…”

Section: Infectious Complicationsmentioning

confidence: 95%

“…In Saudi Arabia the incidence of tuberculosis (TB) is about 8% based on a study of 117 lupus patients [6] . Th ere are no clear guidelines for TB screening in lupus patients but results from several retrospective studies showed a signifi cant number of active and latent TB cases, especially in endemic countries [26,27] .…”

Section: Infectious Complicationsmentioning

confidence: 99%

Pulmonary Manifestations of Systemic Lupus Erythematosus: Global and Saudi Arabian Populations

Bawazir¹,

Aljohaney²

2019

Saudi J Intern Med

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This paper reviews the pulmonary manifestations of systemic lupus erythematosus with particular focus on comparing global and Saudi Arabian populations. Dozens of articles addressing lupus complications in Saudi patients were published in recent years; to our knowledge, this is the first review focusing on pulmonary complications. In this narrative literature review, we conducted a systematic search of MEDLINE and Google Scholar using the words pulmonary complications of systemic lupus in Saudi Arabia. Th e search covered the period between 2000 and 2019. We found that the rate of pulmonary complications in Saudi lupus patients was consistent with that in global patients; exceptionally higher incidence of acute lupus pneumonitis was reported in Saudi patients. We hope that this study will inform clinicians about the important points regarding pulmonary complications in lupus patients, particularly in the Saudi population.

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Analysis of clinical features and prognostic factors in Chinese patients with rheumatic diseases in an intensive care unit

Wang

et al. 2018

The Egyptian Rheumatologist

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Mycobacterium tuberculosis infection in systemic lupus erythematosus patients

Cited by 6 publications

References 31 publications

Global tuberculosis disease and infection in systemic lupus erythematosus patients: A systematic review and meta-analysis

Global tuberculosis disease and infection in systemic lupus erythematosus patients: A systematic review and meta-analysis

Pulmonary Manifestations of Systemic Lupus Erythematosus: Global and Saudi Arabian Populations

Analysis of clinical features and prognostic factors in Chinese patients with rheumatic diseases in an intensive care unit

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