Mycobacterium ulcerans disease (Buruli ulcer) in Gabon: 2005-2011

Manou, L S Bayonne; Portaels, Françoise; Eddyani, Miriam; Book, Alphonse Um; Vandelannoote, Koen; Jong, Bouke C. de

doi:10.1684/mst.2013.0259

Cited by 9 publications

(6 citation statements)

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“…West and Central Africa, Australia, and similar tropical localities have reported an increasing incidence of the disease over the past decade23. Exposure to the bacteria is thought to occur from a yet unknown, but persistent, environmental niche.…”

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confidence: 99%

“…Infection with Mycobacterium ulcerans results in a necrotizing ulceration of the subcutaneous tissue (Buruli Ulcer disease) and is a major cause of morbidity in more than 30 countries 1 . West and Central Africa, Australia, and similar tropical localities have reported an increasing incidence of the disease over the past decade 2 3 . Exposure to the bacteria is thought to occur from a yet unknown, but persistent, environmental niche.…”

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confidence: 99%

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Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans

Hoxmeier

Thompson

Broeckling

et al. 2015

Sci Rep

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Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated the metabolome of the Anopheles gambiae mosquito to profile the metabolic changes associated with bacterial colonization. Contamination of mosquitoes with live M. ulcerans bacilli results in disruptions to lipid metabolic pathways of the mosquito, specifically the utilization of glycerolipid molecules, an affect that was not observed in mosquitoes exposed to dead M. ulcerans. These results are consistent with aberrations of lipid metabolism described in other mycobacterial infections, implying global host-pathogen interactions shared across diverse saprophytic and pathogenic mycobacterial species. This study implicates features of the bacterium, such as the putative M. ulcerans encoded phospholipase enzyme, which promote virulence, survival, and active adaptation in concert with mosquito development, and provides significant groundwork for enhanced studies of the vector-pathogen interactions using metabolomics profiling. Lastly, metabolic and survival data suggest an interaction which is unlikely to contribute to transmission of M. ulcerans by A. gambiae and more likely to contribute to persistence of M. ulcerans in waters cohabitated by both organisms.

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confidence: 99%

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confidence: 99%

Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans

Hoxmeier

Thompson

Broeckling

et al. 2015

Sci Rep

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“…Its preferential site in 9 out of 10 cases is in lower limbs [3, 4]. However, in our experience, we observed some unusual sites.…”

Section: Introductionmentioning

confidence: 52%

Mycobacterium ulceransDisease with Unusual Sites Not to Be Ignored

Sangaré

Hamdan

Isidore

et al. 2014

Dermatology Research and Practice

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Objective. The usual preferential site of BU is in the limbs. In our experience, we noticed atypical and often misleading sites which pose serious issues for the diagnosis and often for the treatment. Methods. This is a retrospective study conducted over a period of ten years of BU treatment at the Department of Dermatology of the University Teaching Hospital of Treichville (Abidjan, Côte d'Ivoire). We included in this study all BU cases with atypical site diagnosed clinically and confirmed either by the histology, by smear, or by PCR. Results. Epidemiologically, the age of patients ranged from 3 to 72 years with a median age of 14.2 years. Children aged less than 15 years were affected in almost 80% of case. The clinical table was dominated by ulcerated forms in 82.1% of cases. The unusual topography mostly observed was that of the torso (thorax, back, and abdomen) in 76.8% of cases. Conclusion. BU is an endemic disease in Côte d'Ivoire where it constitutes a serious public health issue. Several years following its first cases, BU still is little known. This dermatosis may present atypical misleading clinical aspects which must be ignored.

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“…1 ). This left 155 unique articles corresponding to 645 MU detection and/or case fatality rates records included in this review [15] , [24] , [28] , [30] , [33] , [34] , [40] , [54] , [57] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] , [95] , [96] , [97] , [98] , [99] , [100] , [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] , [110] , [111] , [112] , [113] , [114] , [115] , [116] , [117] , …”

Section: Resultsunclassified

“…Six studies from different countries have provided consistent data on the case fatality rate (CFR) of MU in humans ( Supplementary table 9 ). Death occurred in 24 MU positive patients in 5 countries including: Democratic Republic of the Congo that accounted for 3.2–19.4 % [15] , [121] , 7.5 % in Gabon [69] , 1.2 % in Australia [122] , 50 % in case reports in Central African Republic [123] and in Burkina Faso [124] ( Supplementary table 9 ). In Gabon, these patients have a immuno-compromised system due to coinfection of BU and HIV.…”

Section: Global Detection Rate Of Mycobacterium Ulcerans ...mentioning

confidence: 99%

Systematic review: Global host range, case fatality and detection rates of Mycobacterium ulcerans in humans and potential environmental sources

Tchatchouang,

Andre Mbongue Mikangue,

Kenmoe

et al. 2024

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Mycobacterium ulcerans disease (Buruli ulcer) in Gabon: 2005-2011

Cited by 9 publications

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Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans

Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans

Mycobacterium ulceransDisease with Unusual Sites Not to Be Ignored

Systematic review: Global host range, case fatality and detection rates of Mycobacterium ulcerans in humans and potential environmental sources

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