Mycobiome Dysbiosis in Women with Intrauterine Adhesions

Liu, Ningning; Zhao, Xingping; Tan, Jing-Cong; Liu, Sheng; Li, Bowen; Xu, Wanxing; Lin, Peng; Gu, Pan; Li, Waixing; Shapiro, Rebecca; Zheng, Xiaoqi; Zhao, Wenjing; Jiang, Yiguo; Chen, Dan; Xu, Dabao; Wang, Hui

doi:10.1128/spectrum.01324-22

Cited by 18 publications

(21 citation statements)

References 70 publications

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“…Although it has been touched upon in the previous sections of this review, it is important to reiterate the significance of the mycobiome and how dysbiosis in any part of a microbiome can have severe consequences on host health, as well as other communities within the overall microbiome [ 51 ]. While the contributions of bacterial microbiome dysbiosis toward disease have been thoroughly studied, mycobiome dysbiosis has been heavily neglected [ 52 ]. Dysbiosis of the mycobiome occurs from various factors, but some common ones include diet, skin contamination, lifestyle activities, medical treatments or pharmaceuticals, environmental factors, and hygiene practices [ 53 ].…”

Section: Mycobiome Dysbiosismentioning

confidence: 99%

“…One area of mycobiome dysbiosis that has important implications for women is in the vaginal microbiota community [ 52 ]. In a study of intrauterine adhesion (IUA) disease, it was found that certain fungal genera, such as Filobasidium and Exophiala , are more enriched in IUA samples versus healthy subjects [ 52 ]. It has also been shown that fungal–bacterial patterns and interactions exist in this region.…”

Section: Mycobiome Dysbiosismentioning

confidence: 99%

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The Role of the Mycobiome in Women’s Health

Esposito

Patsakos

Borruso

2023

JoF

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Although the human bacteriome and virome have gained a great deal of attention over the years, the human mycobiome has been far more neglected despite having significant value and implications in human health. In women, mycobiome profiles in breastmilk, vaginal regions, the gut, skin, and the oral cavity can provide insight into women’s health, diseases, and microbiome dysbiosis. Analyses of mycobiome composition under factors, such as health, age, diet, weight, and drug exposure (including antibiotic therapies), help to elucidate the various roles of women’s mycobiome in homeostasis, microbiome interactions (synergistic and antagonistic), and health. This review summarizes the most recent updates to mycobiome knowledge in these critical areas.

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Section: Mycobiome Dysbiosismentioning

confidence: 99%

Section: Mycobiome Dysbiosismentioning

confidence: 99%

The Role of the Mycobiome in Women’s Health

Esposito

Patsakos

Borruso

2023

JoF

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“…The study of intrauterine adhesion patients described Candida -related differences in the gut mycobiome composition and numerous fungal–bacterial correlations in cervical canal and middle vagina sites [ 154 ]. There are multiple studies describing the role of Candida strains in the context of vaginal pathophysiology, but there are no studies describing the comprehensive impact of vaginal mycobiome dysbiosis on women´s health.…”

Section: Genitourinary Tract Mycobiomementioning

confidence: 99%

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

Belvončíková

Šplíchalová

Vídeňská

et al. 2022

JoF

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The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth. The initial mycobiome is influenced by the gestational age of a newborn, birth weight, delivery method and feeding method. During a human’s life, the composition of the mycobiome is further influenced by a large number of endogenous and exogenous factors. The most important factors are diet, body weight, age, sex and antibiotic and antifungal therapy. The human mycobiome inhabits the oral cavity, gastrointestinal tract, respiratory tract, urogenital tract and skin. Its composition can influence the gut–brain axis through immune and non-immune mediated crosstalk systems. It also interacts with other commensals of the ecosystem through synergistic and antagonistic relationships. Moreover, colonization of the gut by opportunistic fungal pathogens in immunocompromised individuals can lead to clinically relevant disease states. Thus, the mycobiome represents an essential part of the microbiome associated with a variety of physiological and pathological processes. This review summarizes the current knowledge on the composition of the mycobiome in specific sites of the human body and its role in health and disease.

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“…Reproductive tract fungal infections can have serious effects on women's professional and personal lives 8 , 9 . Harnessing 16S and ITS2 rDNA sequencing analysis, our previous study found that the fungal genera were enriched in the lower genital tract of IUA patients 10 . Moreover, site-specific fungal-bacterial correlation networks were discovered in those patients 10 .…”

Section: Introductionmentioning

confidence: 99%

“…Harnessing 16S and ITS2 rDNA sequencing analysis, our previous study found that the fungal genera were enriched in the lower genital tract of IUA patients 10 . Moreover, site-specific fungal-bacterial correlation networks were discovered in those patients 10 . Vaginal candidiasis is the most common vaginal fungal infection 11 .…”

Section: Introductionmentioning

confidence: 99%

Candida albicans-induced activation of the TGF-β/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion

Zhao

Sun

Zhang

et al. 2023

Sci Rep

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Iatrogenic injury to endometrial tissue is the main cause of intrauterine adhesions (IUA) and infection can also damage the endometrium. The microbiota plays an important role in the health of the female reproductive tract. However, the mechanism is still unclear. In total, 908 patients with IUA and 11,389 healthy individuals were retrospectively selected for this clinical study. Participant information including vaginal microecological results and human papillomavirus (HPV) status were collected. Univariate and multivariate logistic regression analyses were used to identify the factors related to IUA. Next, animal experiments were performed in a curettage-induced IUA rat model. After the procedure, rats in the experimental group received a vaginal infusion of a Candida albicans (C. albicans) fungal solution. On days 3, 7, and 14 after curettage and infusion, the expression levels of IL-6, fibrotic pathway-related factors (TGF-β1, Smad 2, and COL1), and estrogen receptor (ER) and progesterone receptor (PR) in rat endometrial tissues were assessed. Fungal infection of the reproductive tract was found to be an independent risk factor for IUA (P < 0.05). The inflammatory response and degree of fibrosis were greater in rats infected with C. albicans than in the controls. The levels of IL-6, TGF-β1, Smad 2, and COL1 expression in endometrial tissues were significantly higher in the experimental group than in the control group (P < 0.05). However, the ER and PR levels were lower in the IUA group than in the non-IUA group (P < 0.05). C. albicans infection may be related to IUA. C. albicans elicits a strong inflammatory response that can lead to more severe endometrial fibrosis.

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Mycobiome Dysbiosis in Women with Intrauterine Adhesions

Cited by 18 publications

References 70 publications

The Role of the Mycobiome in Women’s Health

The Role of the Mycobiome in Women’s Health

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

Candida albicans-induced activation of the TGF-β/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion

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