Mycobiota dysbiosis and gastric tumorigenesis

Papon, Nicolas; Hohl, Tobias M.; Zhai, Bing

doi:10.7150/thno.61480

Cited by 15 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Table 3 [31]. Together with our findings, these recent advancements not only support that certain commensal fungi might be related to gastrointestinal cancers, [32] but also highlight the feasibility of mycobiota-driven approaches to identify patients at risk of gastrointestinal disease and cancers. Studies using animal models found a ~ 3000-fold fungal increase in PDAC [3].…”

Section: Logistic Regression For Mycobiota Profilesupporting

confidence: 80%

Oral mycobiota and pancreatic ductal adenocarcinoma

et al. 2022

View full text Add to dashboard Cite

Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for survival. Preliminary research demonstrated significant associations between structural alternation of mycobiota and PDAC. In this study, we investigated the associations between oral mycobiota and PDAC. We further explored mycobiota biomarkers for PDAC detection. We enrolled 34 PDAC patients and 35 matched healthy controls from West China hospital in Southwest China. Demographic data, clinical information, and salivary samples were collected. Mycobiota characteristics were defined using Internal Transcribed Spacer (ITS) ribosomal RNA sequencing. We found that the PDAC patients had significant increase in fungal abundance (P < 0.001) and significant decrease in fungal diversity (P < 0.001) in comparison to the healthy controls. A higher abundance of Basidiomycota and Unclassifed_p_Ascomycota was associated with an increased risk of PDAC. With each increase of abundance of g__unclassified_k__Fungi and g__unclassified_p__Ascomycota in PDAC patients, the risk of pancreatic cancer increased by 1.359 odds and 1.260 odds, respectively. Aspergillus (AUC = 0.983, 95% CI 0.951–1.000) and Cladosporium (AUC = 0.969, 95% CI 0.921–1.000) achieved high classification powers to distinguish PDAC patients from the healthy controls. The rapid, inexpensive tests of ITS1 sequencing of mycobiota and PCR detection of potential fungal biomarkers make it promising for the clinical practice to use oral microbes for PDAC early detection and prevention. Results of our study provide evidence that salivary mycobiota may provide insights into cancer risk, prevention, and detection.

show abstract

Section: Logistic Regression For Mycobiota Profilesupporting

confidence: 80%

Oral mycobiota and pancreatic ductal adenocarcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Notably, the existence of a significant correlation between gastric dysbiosis and aforementioned pathologies was observed, highlighting the importance of perturbations in the gastric microbiome in the etiopathology of gastric diseases [ 24 , 27 , 28 , 53 ]. Moreover, an association between dysbiosis of the fungal gastric community and the development of gastritis, ulcers and gastric cancer has been also proven in several studies, indicating the significance of microbiota dysbiosis [ 47 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

In Search for Reasons behind Helicobacter pylori Eradication Failure–Assessment of the Antibiotics Resistance Rate and Co-Existence of Helicobacter pylori with Candida Species

Bačić

Milivojević

Petković

et al. 2023

JoF

View full text Add to dashboard Cite

Helicobacter pylori eradication is characterized by decreasing successful eradication rates. Although treatment failure is primarily associated with resistance to antibiotics, other unknown factors may influence the eradication outcome. This study aimed to assess the presence of the antibiotics resistance genes in H. pylori and the presence of Candida spp., which are proposed to be endosymbiotic hosts of H. pylori, in gastric biopsies of H. pylori-positive patients while simultaneously assessing their relationship. The detection and identification of Candida yeasts and the detection of mutations specific for clarithromycin and fluoroquinolones were performed by using the real-time PCR (RT-PCR) method on DNA extracted from 110 gastric biopsy samples of H. pylori-positive participants. Resistance rate to clarithromycin and fluoroquinolone was 52% and 47%, respectively. Antibiotic resistance was associated with more eradication attempts (p < 0.05). Candida species were detected in nine (8.18%) patients. Candida presence was associated with older age (p < 0.05). A high rate of antibiotic resistance was observed, while Candida presence was scarce, suggesting that endosymbiosis between H. pylori and Candida may not be a major contributing factor to the eradication failure. However, the older age favored Candida gastric mucosa colonization, which could contribute to gastric pathologies and microbiome dysbiosis.

show abstract

“…Research on the role of fungal and viral microbiota in tumors is relatively limited compared to bacteria ( Papon et al, 2021 ). However, studies have identified a significant elevation of Candida albicans in GC patients ( Zhong et al, 2021 ).…”

Section: Gastric Microbial Dysbiosis In Correa’s Cascadementioning

confidence: 99%

The role of gastric microecological dysbiosis in gastric carcinogenesis

Huang,

Zhong,

Wang

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Gastric cancer (GC) is the leading cause of cancer-related death worldwide, and reducing its mortality has become an urgent public health issue. Gastric microecological dysbiosis (including bacteria, fungi, viruses, acid suppressants, antibiotics, and surgery) can lead to gastric immune dysfunction or result in a decrease in dominant bacteria and an increase in the number and virulence of pathogenic microorganisms, which in turn promotes development of GC. This review analyzes the relationship between gastric microecological dysbiosis and GC, elucidates dynamic alterations of the microbiota in Correa’s cascade, and identifies certain specific microorganisms as potential biomarkers of GC to aid in early screening and diagnosis. In addition, this paper presents the potential of gastric microbiota transplantation as a therapeutic target for gastric cancer, providing a new direction for future research in this field.

show abstract

Mycobiota dysbiosis and gastric tumorigenesis

Cited by 15 publications

References 14 publications

Oral mycobiota and pancreatic ductal adenocarcinoma

Oral mycobiota and pancreatic ductal adenocarcinoma

In Search for Reasons behind Helicobacter pylori Eradication Failure–Assessment of the Antibiotics Resistance Rate and Co-Existence of Helicobacter pylori with Candida Species

The role of gastric microecological dysbiosis in gastric carcinogenesis

Contact Info

Product

Resources

About