2017
DOI: 10.1194/jlr.m073171
|View full text |Cite
|
Sign up to set email alerts
|

Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
18
0

Year Published

2018
2018
2022
2022

Publication Types

Select...
3
3

Relationship

1
5

Authors

Journals

citations
Cited by 19 publications
(18 citation statements)
references
References 61 publications
0
18
0
Order By: Relevance
“…Hence, to describe the conformational behavior of free MAs in solution more holistically, it is necessary to further develop a well-defined analysis strategy. Table 4 The percentage, calculated as a percentage of the total number of frames for the 20 Exploring the wider scope of MA conformations A more comprehensive picture of the spread of all the conformations was initially obtained by a principle component analysis (PCA) using the carbon backbone of average WUZstructures combined from extracted frames to map out two principal coordinates for each MA. These principal component plots are shown in Figs.…”
Section: Solvent Effect On Wuz Foldingmentioning
confidence: 99%
See 2 more Smart Citations
“…Hence, to describe the conformational behavior of free MAs in solution more holistically, it is necessary to further develop a well-defined analysis strategy. Table 4 The percentage, calculated as a percentage of the total number of frames for the 20 Exploring the wider scope of MA conformations A more comprehensive picture of the spread of all the conformations was initially obtained by a principle component analysis (PCA) using the carbon backbone of average WUZstructures combined from extracted frames to map out two principal coordinates for each MA. These principal component plots are shown in Figs.…”
Section: Solvent Effect On Wuz Foldingmentioning
confidence: 99%
“…There is now significant evidence that particular MAs and specific MA functionalities have a measurable impact on cell wall permeability, growth, virulence, bacterial proliferation, host immune response, and impact on infected cells [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (reviewed also in [4]). Here, two key features play a significant role; oxygenation of the MA [15][16][17][18][19][20][21][22][23], and cyclopropanation [24][25][26][27], including the specific stereochemistry of the cyclopropane ring [22][23][24][25]. Confirmation of the role of individual MA structures and benchmarked mixtures has recently been achieved through the use of synthetic derivatives [20][21][22][23][31][32][33], and strongly implies that the underlying MA structure (individually or as sugar-ester derivatives), which steers the physical properties and conformational behavior of the molecule, can offer a window to rationalize their biological role.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Interestingly, an involvement of keto MA with cholesterol in vivo has recently been reported by Vermeulen et al . [ 51 ]. These authors wanted to determine the effect that the different MA subclasses have on the growth of the mycobacteria in macrophages, particularly the accumulation of cholesterol brought about by the M .…”
Section: Discussionmentioning
confidence: 99%
“…Recent work suggests mycolic acids, hydrophobic lipids of the bacterial envelope produced only by virulent strains, are responsible for LD and foamy macrophage formation. Specifically, keto‐oxygenated mycolic acids induce cholesterol esterification and the formation of abundant intracellular LDs . Of note, a number of proteins important for LD biogenesis and processing are upregulated in human TB granulomas , suggesting global transcriptional changes during infection.…”
Section: Redirection Of Lipids For the Pathogen's Benefitmentioning
confidence: 99%