Mycology-Nanotechnology Interface: Applications in Medicine and Cosmetology

Dhanjal, Daljeet Singh; Mehra, Parul; Bhardwaj, Sonali; Singh, Reena; Sharma, Parvarish; Nepovimová, Eugenie; Chopra, Chirag; Kuča, Kamil

doi:10.2147/ijn.s363282

Cited by 20 publications

(10 citation statements)

References 207 publications

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“…Among the transitional elements, silver nanoparticles (Ag NPs) are a novel nanometal particle form widely incorporated in biological, therapeutic, and engineering disciplines [ 10 ]. In particular, synthetic biologically active Ag NPs have demonstrated substantial therapeutic aptitudes, including broad-spectrum antimicrobial, anticancer, anti-inflammatory, antioxidative, and antidiabetic action [ 11 , 12 ]. A modern review of the synthesis of Ag NPs and their uses in antimicrobial textile fabrics, food packaging films, and wound dressings is provided by Chengzhu L. et al The antibacterial activity and cytotoxic effect in mammalian cells are given special consideration [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Identifying the Anti-MERS-CoV and Anti-HcoV-229E Potential Drugs from the Ginkgo biloba Leaves Extract and Its Eco-Friendly Synthesis of Silver Nanoparticles

et al. 2023

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The present study aimed to estimate the antiviral activities of Ginkgo biloba (GB) leaves extract and eco-friendly free silver nanoparticles (Ag NPs) against the MERS-CoV (Middle East respiratory syndrome-coronavirus) and HCoV-229E (human coronavirus 229E), as well as isolation and identification of phytochemicals from GB. Different solvents and high-performance liquid chromatography (HPLC) were used to extract and identify flavonoids and phenolic compounds from GB leaves. The green, silver nanoparticle synthesis was synthesized from GB leaves aqueous extract and investigated for their possible effects as anti-coronaviruses MERS-CoV and HCoV-229E using MTT assay protocol. To verify the synthesis of Ag NPs, several techniques were employed, including X-ray diffraction (XRD), scan, transmission electron microscopy, FT-IR, and UV–visible spectroscopy. The highest contents of flavonoids and phenolic compounds were recorded for acetone, methanol, and ethanol as mixtures with water, in addition to pure water. HPLC flavonoids were detected as apegenin, luteolin, myricetin, and catechin, while HPLC phenolic compounds were pyrogallol, caffeic acid, gallic acid, and ellagic acid. In addition, our results revealed that Ag NPs were produced through the shift from yellow to dark brown. TEM examination of Ag NPs revealed spherical nanoparticles with mean sizes ranging from 5.46 to 19.40 nm and an average particle diameter of 11.81 nm. A UV–visible spectrophotometric investigation revealed an absorption peak at λ max of 441.56 nm. MTT protocol signified the use of GB leaves extract as an anti-coronavirus to be best from Ag NPs because GB extract had moderate anti-MERS-CoV with SI = 8.94, while had promising anti-HCov-229E, with an SI of 21.71. On the other hand, Ag NPs had a mild anti-MERS-CoV with SI = 4.23, and a moderate anti-HCoV-229E, with an SI of 7.51.

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Section: Introductionmentioning

confidence: 99%

Identifying the Anti-MERS-CoV and Anti-HcoV-229E Potential Drugs from the Ginkgo biloba Leaves Extract and Its Eco-Friendly Synthesis of Silver Nanoparticles

et al. 2023

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“…These include drug delivery, 4 antiviral properties, 5 antifungal, 6 anti-parasitic, 7 therefore, they are very often used in medicine, 8 pharmacy, 9 and cosmetology. 10 In vitro studies also confirm anticancer activities of nanocomposites. 11 …”

Section: Introductionmentioning

confidence: 79%

Evaluation of the Antimicrobial, Cytotoxic, and Physical Properties of Selected Nano-Complexes in Bovine Udder Inflammatory Pathogen Control

Wierzbicki,

Kot,

Lange

et al. 2024

NSA

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Purpose Mastitis in dairy cows is a worldwide problem faced by dairy producers. Treatment mainly involves antibiotic therapy, however, due to widespread antibiotic resistance among bacteria, such treatments are no longer effective. For this reason, scientists are searching for new solutions to combat mastitis , which is caused by bacteria, fungi, and algae. One of the most promising solutions, nanotechnology, is attracting research due to its biocidal properties. The purpose of this research was to determine the biocidal properties of nanocomposites as a potential alternative to antibiotics in the control of mastitis , as well as to determine whether the use of nanoparticles and what concentration is safe for the breeder and the animal. Patients and Methods In this study, the effects of Ag, Au, Cu, Fe, and Pt nanoparticles and their complexes were evaluated in relation to the survival of bacteria and fungi isolated from cattle diagnosed with mastitis , their physicochemical properties, and their toxicity to bovine and human mammary epithelial cells BME-UV1 and HMEC (human microvascular endothelial cells). Moreover, E. coli, S. aureus, C. albicans , and Prototheca sp. invasion was assessed using the alginate bead (bioprinted) model. The NPs were tested at concentrations of 25, 12.5, 6.25, 3.125, 1.56 mg/l for Au, Ag, Cu and Fe NPs, and 10, 5, 2.5, 1.25, 0.625 mg/l for Pt. Results With the exception of Fe and Pt, all exhibited biocidal properties against isolates, while the AgCu complex had the best effect. In addition, nanoparticles showed synergistic effects, while the low concentrations had no toxic effect on BME-UV1 and HMEC cells. Conclusion Synergistic effects of nanoparticles and no toxicity to bovine and human cells might, in the future, be an effective alternative in the fight against microorganisms responsible for mastitis , and the implementation of research results in practice would reduce the percentage of dairy cows suffering from mastitis . The problem of increasing antibiotic resistance is posing a global threat to human’s and animal’s health, and requires comprehensive research to evaluate the potential use of nanoparticles – especially their complexes – as well as to determine whether nanoparticles are safe for the breeders and the animals. The conducted series of studies allows further consideration of the use of the obtained results in practice, creating a potentially new alternative to antibiotics in the treatment and prevention of mastitis in dairy cattle.

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“…29 One common strategy is to modify biomaterial surfaces in terms of chemistry, wettability, topography, stiffness, electrical charge, and porosity. 30 In recent years, rapid progress has been made in the production of smart biomaterials, ranging from using external stimulation to enhance therapeutic effects and bone regeneration, to sensing and intelligently responding to changes in the internal microenvironment.…”

Section: Biomaterials Science Perspectivementioning

confidence: 99%