Mycophenolate Mofetil and Cough

Elli, A.; Aroldi, A.; Montagnino, G.; Tarantino, A; Ponticelli, Claudio

doi:10.1097/00007890-199808150-00026

Cited by 18 publications

(6 citation statements)

References 4 publications

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“…Their patient’s respiratory symptoms resolved after discontinuation of MMF. In the same year, Elli et al suggested cough and dyspnea as a potential side-effect of MMF [26]. Since these reports, four separate case reports and three case series have been reported on the effects of MMF on the lung post-transplantation (Table 1) [13–19].…”

Section: Discussionmentioning

confidence: 99%

Mycophenolate Mofetil and Pulmonary Fibrosis After Kidney Transplantation: A Case Report

Takahashi

Stone

et al. 2017

Am J Case Rep

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Patient: Male, 50Final Diagnosis: Pulmonary fibrosisSymptoms: Short of breathMedication: —Clinical Procedure: —Specialty: TransplantologyObjective:Adverse events of drug therapyBackground:Mycophenolate mofetil (MMF) induced lung disease has been described in only a few isolated reports. We report a case of fatal respiratory failure associated with MMF after kidney transplantation.Case Report:A 50-year-old Hispanic male with a history of end-stage renal disease secondary to hypertension underwent deceased donor kidney transplantation. His preoperative evaluations were normal except for a chest x-ray which showed bilateral interstitial opacities. Tacrolimus and MMF were started on the day of surgery. His postoperative course was uneventful and he was discharged on postoperative day 5. One month later, he presented with shortness of breath and a cough with blood-tinged sputum. His respiratory condition deteriorated rapidly, requiring intubation. Chest computer tomography (CT) demonstrated patchy ground-glass opacities with interlobular septal thickening. Comprehensive pulmonary, cardiac, infectious, and immunological evaluations were all negative. Open lung biopsy revealed extensive pulmonary fibrosis with no evidence of infection. He temporarily improved after discontinuation of tacrolimus and MMF, however, on resuming MMF his respiratory status deteriorated again and he subsequently died from hypoxic respiratory failure.Conclusions:An awareness of pulmonary lung disease due to MMF is important to prevent adverse outcomes after organ transplantation. MMF must be used with utmost care in recipients with underlying lung disease as their pulmonary condition might make them more susceptible to any harmful effects of MMF.

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Section: Discussionmentioning

confidence: 99%

Mycophenolate Mofetil and Pulmonary Fibrosis After Kidney Transplantation: A Case Report

Takahashi

Stone

et al. 2017

Am J Case Rep

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“…The paradoxical effect that MMF may lead to pulmonary fibrosis has a less apparent pathophysiology, and is rarely identified. MMF has been implicated in the development of pulmonary pathology in several situations, ranging from acute pulmonary fibrosis shortly following transplant (10–12) to more protracted cough and dyspnoea (13). It has also been implicated in the development of bronchiectasis in the paediatric post‐transplant population (14), though the mechanics of this are unknown.…”

Section: Discussionmentioning

confidence: 99%

Reversible chronic pulmonary fibrosis associated with MMF in a pediatric patient: A case report

Reynolds

Paton

Howatson

et al. 2007

Pediatric Transplantation

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“…There is a report of five kidney transplant patients who developed cough after taking mycophenolate mofetil (Elli et al 1998). Despite normal chest radiography, nonproductive cough occurred 36 to 84 days after these patients were administered the drug, and only discontinuation of mycophenolate mofetil reduced the cough symptoms (Elli et al 1998). Omeprazole is one of widely used proton pump inhibitors to relieve peptic symptoms in patients with gastroesophageal acidic reflux diseases (Kahrilas et al 2013).…”

Section: Mycophenolate Mofetilmentioning

confidence: 99%

Drug-Induced Cough

Shim

Song

Morice³

2020

Physiol Res

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Since the recognition of angiotensin-converting enzyme inhibitors (ACEIs)-induced cough, drug has been considered as a potential cause of chronic cough. This review presents recent knowledge on drug-induced coughs in patients with chronic cough. The focus is placed on ACEIs, for which there are a multitude of studies documenting their associations with cough. Additional drugs are discussed for which there are reports of cough as a side effect of treatment, and the potential mechanisms of these effects are discussed.

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Mycophenolate Mofetil and Cough

Cited by 18 publications

References 4 publications

Mycophenolate Mofetil and Pulmonary Fibrosis After Kidney Transplantation: A Case Report

Mycophenolate Mofetil and Pulmonary Fibrosis After Kidney Transplantation: A Case Report

Reversible chronic pulmonary fibrosis associated with MMF in a pediatric patient: A case report

Drug-Induced Cough

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