Mycophenolate Mofetil for the Treatment of Uveitis

Mycophenolate mofetil monotherapy in the management of paediatric uveitis

“…[23][24][25][26][27][28] The results of these studies, however, do not specifically address the effectiveness and safety of MMF in children. Before the present report, the effectiveness of MMF exclusively in treatment of paediatric uveitis had only been demonstrated in the case series study of 17 children conducted by Doycheva et al 29 In support of that previous work, our data suggest that MMF monotherapy is an effective steroid-sparing treatment in paediatric autoimmune uveitis.…”

“…[23][24][25][26][27][28][29][30] In the present study, it took about 5 months to develop these adverse effects while on MMF therapy. In about one-fifth of the study population, the adverse effects were significant, but a decrease in MMF dosage was able to bring the effects under control in approximately half of these patients.…”

Current concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation

“…Over the last few years, assisted by major expert opinion overview articles that provided treatment recommendations, 49 there have been further seminal trials and patient cohort studies highlighting the evidence for treatment with non-biologic conventional immunosuppressants. 4,7,[50][51][52][53][54][55][56][57][58] The most compelling studies of recent years include evidence from patient cohort analytical studies for the use of cellcept displaying its effectiveness as a corticosteroid-sparing agent with an acceptable adverse event profile. 4,7,59 In particular, there are two studies that presented their results in accordance with SUN guidelines showing concordance in effect, with around an 80% chance of achieving disease control at a prednisolone dose of o10 mg/day.…”

“…55 A cohort analysis of 62 patients has since revealed that patients on tacrolimus had an 85% probability of achieving remission and o10 mg/day of prednisolone with an excellent cardiovascular risk profile. 58 The efficacy of voclosporin has also since been assessed in the international Lux Uveitis Multicenter Investigation of a New Approach to Treatment (LUMINATE) studies. 61,62 These included, for active non-infectious uveitis, a RCT of 218 patients, which showed that 0.4 mg/kg achieved its primary endpoint of superiority to placebo, using suppression of vitreous haze as a readout of intraocular inflammation.…”

Treatment Approach for Juvenile Idiopathic Arthritis-Related Uveitis: 2012 Update

“…Исследования применения препарата у детей, стра-дающих увеитом, показали, что ММФ позволяет сни-зить потребность в гормональной терапии у большинства пациентов, однако лишь у некоторых из них не отмеча-ется рецидивов, в то время как у значительной части наблюдаемых улучшалась острота зрения или не реги-стрировалось ее ухудшения [26,27]. Побочные эффекты легкой степени выраженности, как, например, голов-ная боль, кожные высыпания и дискомфорт со стороны желудочно-кишечного тракта, были зарегистрированы приблизительно у 40% пациентов.…”