In 1937, Dermatologist Hulusi Behcet presented a case of a patient with a 7-year history of recurrent ocular lesions, oral aphthous ulcers, and genital ulcers. The case report with the addition of a similar one was published in 1937. 1 Behcet published three more relevant papers most importantly pointing toward a single disease-syndrome from 1938 to 1940. In 1930, the Ophthalmologist Benedictos Adamantiades had described a case report of a disease with the title "A case of relapsing iritis with hypopyon." 2 Interestingly, we find Adamantiades-Behcet's disease (ABD) descriptions not only from Hippocrates of Kos but also from clinical observations similar to ABD disease recorded from 1772 to 1940. 3,4 Adamantiades-Behcet's disease (ABD) is a chronic, multisystem inflammatory disorder, which is clinically characterized mainly by relapsing oral aphthous, genital ulcers, ocular, and vascular lesions.The disease may affect small and large vessels in almost all organs.
B-cell inhibitorsRituximab for ocular involvement
Interleukin inhibitors monoclonal antibodiesAnakinra (IL 1) Canakinumab (IL1) Mucocutaneous involvement Ustekinumab (IL 12, IL 23) Tocilizumab (IL 6) Selective costimulation modulators Abatacept ocular, cutaneous involvement Apremilast phosphodiesterase inhibitor PDE4 Anti TNF Adalimumab, Infiximab eye, deep vein thrombosis, GI involvement, nervous system involvement Etanercept arthritis, mucocutaneous involvement TA B L E 2 Categories of biologic agents under study and in use.