Mycophenolic Acid Pharmacokinetics Early After Kidney Transplant

Abstract

Objectives: To determine the mycophenolic acid pharmacokinetic profile early after transplant in Iranian kidney graft recipients. Materials and Methods: A cross-sectional study was performed during 6 months in 31 patients who recently had kidney transplant and received fixed doses of mycophenolate mofetil (2 g/d). The plasma levels of mycophenolic acid were determined by high performance liquid chromatography. Results: The mean first mycophenolic acid peak level was 10 ± 5 mg/L. The mean mycophenolic acid area under the curve was 26 ± 19 mgh/L and apparent clearance was 57 ± 55 L/h. The mycophenolic acid area under the curve values of only 8 patients (26%) were within the therapeutic range (30-60 mgh/L). The first, second, and third mycophenolic acid peak levels correlated significantly with mycophenolic acid area under the curve (P < .05). Mycophenolic acid concentration at 10 hours had the highest correlation with mycophenolic acid area under the curve (r=0.962; P < .05). No statistically significant differences were evident in the mean mycophenolic acid area under the curve between men and women. Conclusions: There was a high degree of variation between different patients in mycophenolic acid pharmacokinetics early after kidney transplant.

Mycophenolic Acid Concentration on Vietnamese Renal Transplant Recipients

“…In Thai kidney transplant recipients, MPA concentration at 2 hours had the highest correlation with MPA-AUC (r = 0.622); the time of the study was 4 months (19). In the study of Honarbakhsh et al (20), the recipients showed one peak, two peaks, or three peaks, and the time of the study was days 9 or 10. These differences depended on many factors including race, immunosuppression protocol, time from transplant, or MMF dosage.…”