Mycoplasma adaptation to stress conditions: Proteome shift in Mycoplasma hominis PG37 in response to starvation and low temperatures

Чернов, В. М.; Чернова, О. А.; Baranova, N. B.; Gorshkov, Oleg; Medvedeva, E. S.; Shaymardanova, G. F.

doi:10.1134/s0026893311050037

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…This inconsistent history has made it challenging to clarify the role of these bacteria. The host-pathogen relationship is a complex and variable subject, but some interactions that have been studied have helped better understand this important relationship [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Mycoplasma genitalium and Mycoplasma hominis in urogenital tract of Brazilian women

et al. 2015

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BackgroundThe role of Mycoplasma hominis and M. genitalium in urogenital tract infections remains unknown. Furthermore these mollicutes present a complex relationship with the host immune response. The role of inflammatory cytokines in infections also makes them good candidates to investigate bacterial vaginosis and mycoplasma genital infections. Therefore, the aim of this study was to detect the above-mentioned mollicutes by quantitative Polymerase Chain Reaction (qPCR) methodologies in vaginal swabs and dosage of cytokines.MethodsVaginal swabs and peripheral blood were collected from 302 women, including healthy individuals. The molecular findings were correlated with some individual behavioral variables, clinical and demographic characteristics, presence of other important microorganisms in vaginal swabs, and levels of interleukin (IL)-1β and IL-6.ResultsM. hominis and M. genitalium were detected in 31.8% and 28.1% of samples, respectively. The qPCR results were associated with clinical signs and symptoms of the infections studied. The frequency of Trichomonas vaginalis, Gardnerella vaginalis, Neisseria gonorrhoeae and Chlamydia trachomatis was 3.0%, 21.5%, 42.4%, and 1.7% respectively. Increased levels of IL-1β were associated with the presence of M. hominis and signs and/or symptoms of the genital infection of women studied.ConclusionIL-1β production was associated with the detection of M. hominis by qPCR. The sexual behavior of women studied was associated with the detection of mycoplasma and other agents of genital infections.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-015-0792-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Mycoplasma genitalium and Mycoplasma hominis in urogenital tract of Brazilian women

et al. 2015

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“…However, five decades ago, some Mollicutes were considered to be infectious agents of the human urogenital tract (16). This inconsistent history has made it challenging to clarify the role of these bacteria (17). Mycoplasma hominis is associated with nongonococcal urethritis (NGU), bacterial vaginosis, and post-birth fever (18).…”

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confidence: 99%

Mycoplasma genitalium can modulate the local immune response in patients with endometriosis

Campos

Marques

Rezende

et al. 2018

Fertility and Sterility

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“…Hence exploration of novel targets for antimycoplasma antibiotics is essential 47,48,49 . These novel targets are being investigated and are usually based on protein 46,50 , gene 47,51 , enzymes 52 or metabolism 53 . In addition a number of novel targets are being elucidated 44,47,48,49 and future research will help in identifying specific and effective therapeutic targets in future.…”

Section: Novel Targets For Antimycoplasma Therapymentioning

confidence: 99%

“…Target alterations, in ribosome and in topoisomerase II genes have been found as resistance mechanisms to macrolide and tetracycline and fluoro-quinolone class of antibiotics, respectively 44,45 . However other mechanisms of antibiotic resistance in mycoplasma need to be explored 46 .…”

Section: Introductionmentioning

confidence: 99%

“…These include the follow ups for antibiotic sensitivity testing, employing alternativeantibiotics, and alternate therapies. Novel targets are based on proteomics 46,50 , genomics, enzymes 52 or metabolism 53 , besides there are numerous other novel targets which are under investigation 44,47,48,49 and further exploration can help in identifying specific and effective therapeutic and drug targets in future. All these measures will help in preventing antibiotic resistance in mycoplasma, emergence of resistant species, exploring novel targets, safe and effective therapy of mycoplasma diseases in future.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Antibiotic Resistance in Mycoplasma Microorganisms, Designing Effective and Novel Drugs / Therapeutic Targets: Current Knowledge and Futuristic Prospects

Yatoo¹,

Parray²,

Bhat³

et al. 2019

J Pure Appl Microbiol

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Emerging antibiotic resistance among mycoplasma microorganisms is of major concern in present times as they cause various diseases in both animals and humans. Mycoplasmoses, infections caused by mycoplasma microorganisms have become common in recent past and have gained importance both due to inability to diagnose and difficulty to treat. Respiratory tract infection, mastitis, arthritis, and septicemia caused by Mycoplasma in livestock are responsible for causing heavy economic losses. These diseases are frequently reported from countries of Africa and Asia, including India. Antimycoplasma antibiotics are frequently being used as therapeutic agents for the treatment of mycoplasmoses infection in livestock. They include macrolides, tetracyclines, fluoroquinolones, and aminoglycosides which are the main antibiotic classes commonly used against mycoplasma globally. Oxytetracyclines are the commonest antibiotics used for decades followed by enrofloxacin, tylosin, and streptomycin. Danofloxacin, lincomycin, spiramycin, erythromycin, gamithromycin, azithromycin, clarithromycin, gentamicin, doxycycline, and tulathromycin are also used occasionally. Continuous and unregulated use of these antibiotics over prolonged period can lead to menace of antibiotic resistance which is aided by inappropriate doses and uncontrolled use. Resistance to some antibiotics is already emerging. Mycoplasmas have devised different resistance mechanisms for combating antimicrobial action of these drugs. Common mechanisms noted are acquisitions of proteins affecting ribosomal subunits, inhibition of antibiotic efflux, structural changes in the ribosomal subunit, target mutations, expression or production of enzymes. Additional novel mechanisms of resistance still need to be investigated. Strategies for prevention and encountering of this antibiotic resistance are being devised by alternating antibiotics in application, using antimycoplasma antibiotic sensitivity tests, along with evaluation of specific doses and exploration of novel mycoplasma specific class of antibiotics. Novel targets based on various cell structures including cell membrane, organelles, proteins, enzymes or metabolites are being explored for antimycoplasma therapy. These all will help in effective therapeutic management of mycoplasmoses with minimal side effects.

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Mycoplasma adaptation to stress conditions: Proteome shift in Mycoplasma hominis PG37 in response to starvation and low temperatures

Cited by 5 publications

References 26 publications

Prevalence of Mycoplasma genitalium and Mycoplasma hominis in urogenital tract of Brazilian women

Prevalence of Mycoplasma genitalium and Mycoplasma hominis in urogenital tract of Brazilian women

Mycoplasma genitalium can modulate the local immune response in patients with endometriosis

Emerging Antibiotic Resistance in Mycoplasma Microorganisms, Designing Effective and Novel Drugs / Therapeutic Targets: Current Knowledge and Futuristic Prospects

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