Mycoplasma hominisnecrotizing pleuropneumonia in a previously healthy adolescent

Pascual, Andrés; Perez, Marie-Hélène; Jaton, Katia; Hafen, Gaudenz; Bernardo, Stefano Di; Cotting, Jacques; Greub, Gilbert; Vaudaux, Bernard

doi:10.1186/1471-2334-10-335

Cited by 21 publications

(19 citation statements)

References 22 publications

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“…Increasingly, basic and clinical research suggest that urogenital strains of Mycoplasma can cause respiratory disease not just in immunocompromised, but even healthy adults and children and are often not easy to identify or treat 29 . While we did not find a definitive link between the presence of individual organisms and chronic lung disease in this study cohort, patients positive for Mycoplasma 16S DNA were more often asthmatic.…”

Section: Discussioncontrasting

confidence: 75%

“…It is not clear what role, if any, the urogenital Mycoplasmas and Ureaplasma play in acute or chronic respiratory disease. Increasing evidence suggests that these urogenital Mycoplasmas can be the cause of serious extra‐genital infections, mainly in immunocompromised patients, although extragenital infections are uncommon in healthy patients and cases of pneumonia are exceptional 29 . In recent studies the urogenital Mycoplasmas have been associated with respiratory distress in newborns 30 and neonatal meningitis 31 .…”

Section: Discussionmentioning

confidence: 99%

“…It is not clear what role, if any, the urogenital Mycoplasmas and Ureaplasma play in acute or chronic 29 In recent studies the urogenital Mycoplasmas have been associated with respiratory distress in newborns 30 and neonatal meningitis. 31 The Ureaplasmas have been linked with preterm labour, 32 intrauterine lung disease 33 and neonatal pneumonia.…”

Section: Discussionmentioning

confidence: 99%

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Colonization of paediatric lower respiratory tract with genital Mycoplasma species

2011

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Colonization of paediatric lower respiratory tract with genital Mycoplasma species

2011

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“…Mycoplasma are eukaryote commensals and can cause severe pathologies in humans (Uphoff and Drexler, 2005; Myers et al, 2010; Pascual et al, 2010). As shown in Figure 1F, the peptide efficiently cleared mycoplasma from infected eukaryote cell cultures.…”

Section: Resultsmentioning

confidence: 99%

The Anticancer Peptide TAT-RasGAP317−326 Exerts Broad Antimicrobial Activity

et al. 2017

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Antibiotic resistance has become a major health issue. Nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. Therefore, there is an urgent need to develop new classes of antibiotics effective on multi-resistant nosocomial pathogenic bacteria. We have previously shown that a cell-permeable peptide derived from the p120 Ras GTPase-activating protein (RasGAP), called TAT-RasGAP317−326, induces cancer cell death, inhibits metastatic progression, and sensitizes tumor cells to various anti-cancer treatments in vitro and in vivo. We here report that TAT-RasGAP317−326 also possesses antimicrobial activity. In vitro, TAT-RasGAP317−326, but not mutated or truncated forms of the peptide, efficiently killed a series of bacteria including Escherichia coli, Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa. In vivo experiments revealed that TAT-RasGAP317−326 protects mice from lethal E. coli-induced peritonitis if administrated locally at the onset of infection. However, the protective effect was lost when treatment was delayed, likely due to rapid clearance and inadequate biodistribution of the peptide. Peptide modifications might overcome these shortcomings to increase the in vivo efficacy of the compound in the context of the currently limited antimicrobial options.

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“…MH can cause a wide range of diseases, such as genital infections in adults and may be involved in infections in premature and low birth-weight infants with clinical manifestations of septicaemia (Gonzalez-Jimenez et al , 2006; Karabay et al , 2006; Koshiba et al , 2011). This tiny microorganism can also invade in central nervous system, joint, peritonitis, pyelonephritis and respiratory tract (Garcia et al , 2007; Kacerovsky et al , 2009; Koshiba et al , 2011; Krijnen R. et al , 2006; Myers et al , 2010; Pascual 2010). Barykova (2011) reported that MH infection may be involved in Prostate Cancer development.…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis clinical isolates

De-sheng¹,

Sun²,

Yu³

et al. 2014

Braz. J. Microbiol.

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To evaluate the molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis (MH) clinical strains isolated from urogenital specimens. 15 MH clinical isolates with different phenotypes of resistance to fluoroquinolones antibiotics were screened for mutations in the quinolone resistance-determining regions (QRDRs) of DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC and parE) in comparison with the reference strain PG21, which is susceptible to fluoroquinolones antibiotics. 15 MH isolates with three kinds of quinolone resistance phenotypes were obtained. Thirteen out of these quinolone-resistant isolates were found to carry nucleotide substitutions in either gyrA or parC. There were no alterations in gyrB and no mutations were found in the isolates with a phenotype of resistance to Ofloxacin (OFX), intermediate resistant to Levofloxacin (LVX) and Sparfloxacin (SFX), and those susceptible to all three tested antibiotics. The molecular mechanism of fluoroquinolone resistance in clinical isolates of MH was reported in this study. The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is likely associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.

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Mycoplasma hominisnecrotizing pleuropneumonia in a previously healthy adolescent

Cited by 21 publications

References 22 publications

Colonization of paediatric lower respiratory tract with genital Mycoplasma species

Colonization of paediatric lower respiratory tract with genital Mycoplasma species

The Anticancer Peptide TAT-RasGAP317−326 Exerts Broad Antimicrobial Activity

Molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis clinical isolates

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