Mycoplasma-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: Case-control analysis of a cohort managed in a specialized center

Liew, Yasmin Chia Chia; Choo, Karen Jui Lin; Oh, Choon Chiat; Pang, Shiu Ming; Yeo, Yoomi; Lee, Haur Yueh

doi:10.1016/j.jaad.2021.04.066

Cited by 12 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The causes of SJS/TEN include infection, drugs, and immunity (4). MP infection is associated with SJS/TEN (5). An investigation into outbreaks of MP-associated SJS revealed 3-X-6-2 MP strain is more common in SJS patients than patients with pneumonia only (6).…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans associated with toxic epidermal necrolysis induced by infection: A case report and literature review

et al. 2023

View full text Add to dashboard Cite

BackgroundStevens-Johnson syndrome/toxic epidermal necrolysis has a severe impact on patients' eyes, genital mucosa, and many other organs. Bronchiolitis obliterans is a rare complication of Stevens-Johnson syndrome/toxic epidermal necrolysis.Data sourcesWe report a case of bronchiolitis obliterans associated with toxic epidermal necrolysis in our department. Furthermore, we examined the patients with bronchiolitis obliterans induced by Stevens-Johnson syndrome/toxic epidermal necrolysis and summarized the clinical characteristics, treatment, and prognosis. Databases available online in English including PubMed, Medline, and Web of Science were consulted.ResultsWe report one case and review 23 published case reports. Of the 24 patients, 13 were female, the oldest patient was 59 years old and the youngest was 5 years old. The time of bronchiolitis obliterans onset after Stevens-Johnson syndrome/toxic epidermal necrolysis varied from 5 days to 5 months. Bronchoscopy examination showed ulceration, exudative lesions, occlusion, and inflammation. The CT of lung manifestation included mosaic perfusion, bronchiectasis, consolidation, air trapping, pneumatocele, pleural thickening, lung collapse, larger central airway dilatation, lung overinflation, oligemia, and pneumomediastinum. Most cases indicated pulmonary function tests with obstructive ventilation dysfunction. The prognosis was poor; six of the patients died.ConclusionsPatients with Stevens-Johnson syndrome/toxic epidermal necrolysis may develop bronchitis obliterans at different stages, so all patients with Stevens-Johnson syndrome/toxic epidermal necrolysis should be followed up for possible respiratory complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans associated with toxic epidermal necrolysis induced by infection: A case report and literature review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Mycoplasmainduced cases carried statistically lower rates of mortality (0%) compared with medication-induced cases (22.5%). 7 Another prospective open-label study evaluated SJS/TEN management by randomizing 25 patients to receive either combination therapy with methylprednisolone plus a tumor necrosis factor α inhibitor or methylprednisolone alone. 8 Anti-tumor necrosis factor therapy was associated with a shorter length of initial steroid treatment and duration of the acute stage, hospitalization, and time to re-epithelialization 8 ; however, as in a prior randomized unblinded trial, 9 there was no difference in mortality between the 2 groups.…”

Section: U T I S D O N O T C O P Ymentioning

confidence: 99%

Hospital Dermatology: Review of Research in 2022-2023

Berk-Krauss

2023

Cutis

View full text Add to dashboard Cite

“…Stevens-Johnson syndrome (SJS) and toxic epidermaly necrolysis (TEN) are rare potentially fatal severe cutaneous adverse reactions characterized by extensive epidermal detachment and mucocutaneous involvement (Supplement Table 5, http://links.lww.com/MOP/A66) [46 ▪▪ ]. They are almost always drug-related with occasional infectious etiology [14,42].…”

Section: Stevens-johnson Syndromementioning

confidence: 99%

“…Interestingly, in pediatric cohorts, infections account for a higher proportion of SJS/TEN cases than in adults [43]. In particular, Mycoplasma pneumoniae has been shown to trigger an SJS/TEN presentation that is clinically indistinguishable from classic medication-induced cases [46 ▪▪ ]. Any mucosal surface may be affected by SJS/TEN including oropharyngeal, genital, and ocular sites, with involvement of at least two sites required for diagnosis [44,47].…”

Section: Stevens-johnson Syndromementioning

confidence: 99%

The eyes have it: when skin findings prompt referral to ophthalmology

Dunn¹,

Foss²,

Kumar

2022

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of reviewCo-presentation of ocular and cutaneous conditions is common and prompt recognition of known associations may be imperative to sight-saving intervention. There are currently limited reviews in the pediatric literature addressing comorbid ocular and dermatologic presentations. Recent diagnostic and therapeutic advances have drastically altered the prognostic landscape for several disease states when recognition and referral are timely. The aim of this report is to examine important oculocutaneous disease associations with emphasis on management of ocular complications and appropriate referral practices to ophthalmology specialists. Recent findingsOculocutaneous associations can be broadly classified into four etiologic categories: infectious, inflammatory, genetic, and medication/nutrition induced pathology. Several conditions in all four categories have had recent advances in their etiologic understanding, diagnostic evaluation, and therapeutic approach. Thematically, these advances highlight increasing disease prevalence of certain conditions, previously unrecognized pediatric relevance of others, updated diagnostic criteria, and newer categories of iatrogenic illness induced by advances in medical therapy.

show abstract

Mycoplasma-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: Case-control analysis of a cohort managed in a specialized center

Cited by 12 publications

References 23 publications

Bronchiolitis obliterans associated with toxic epidermal necrolysis induced by infection: A case report and literature review

Bronchiolitis obliterans associated with toxic epidermal necrolysis induced by infection: A case report and literature review

Hospital Dermatology: Review of Research in 2022-2023

The eyes have it: when skin findings prompt referral to ophthalmology

Contact Info

Product

Resources

About