Mycoplasma pneumoniae Disease: Clinical Spectrum, Pathophysiology, Epidemiology, and Control

Fw, Denny; Wa, Clyde; Wp, Glezen

doi:10.1093/infdis/123.1.74

Cited by 234 publications

(95 citation statements)

References 55 publications

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“…However, this serological survey must be viewed against the background that the specimens were from patients in whom the physician suspected a current 11. pneumoniae illness, and 59 % of these MPCF-positive patients also had a positive CA test supporting the diagnosis [1,5]. Furthermore, 4066 or 44 % of the patients had MPCF titres of > 512, and 10% of the total had significant changes in titre.…”

Section: Resultsmentioning

confidence: 85%

“…Though non-specific, this test has been retained as a supplement to the MPCF test, because CA develop 195 in more than half the patients with M. pneumoniae infection, and they are usually the first antibodies detected and also the first to disappear [5].…”

Section: Resultsmentioning

confidence: 99%

“…This is in accordance with findings of Fernald and colleagues [11] and Brunner and colleagues [14], who reported that the infection is often asymptomatic in infants and young children. In their review, Denny and colleagues [5] state that M. pneumoniae disease is recognized infrequently in patients younger than 5 years of age.…”

Section: Resultsmentioning

confidence: 99%

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Ten and a half years seroepidemiology ofMycoplasma pneumoniaeinfection in Denmark

Lind¹,

Bentzon

1991

Epidemiol. Infect.

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SUMMARYThe study was based on a computerized card index of 9161 patients who had at least one positive blood specimen in the Mycoplasma pneumoniae complement fixation test. A total of 12562 specimens from these patients had been sent to Statens Seruminstitut from hospitals and general practitioners during a 10-5-year period. The period encompassed a previously described endemic period in a 30-year study of the epidemiological pattern ofM. pneumoniae infection in Denmark [1]. The serological data presented support the hypothesis advanced here that a more than sixfold increase of children in day care might have contributed to a change in the epidemiological pattern. The correlation between age and level of specific antibodies, as well as persistence of seropositivity, were also investigated.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ten and a half years seroepidemiology ofMycoplasma pneumoniaeinfection in Denmark

Lind¹,

Bentzon

1991

Epidemiol. Infect.

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“…The occurrence of M. pneumoniae CAP throughout the year is a well-documented finding in the literature [1,[14][15][16][17][18][19][20]. Seasonal peaks have been reported in only some of these studies.…”

Section: Discussionmentioning

confidence: 99%

Seasonal variation in community-acquired pneumonia

Lieberman

Porath²

1996

Eur Respir J

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S Se ea as so on na al l v va ar ri ia at ti io on n i in n c co om mm mu un ni it ty y--a ac cq qu ui ir re ed d p pn ne eu um mo on ni ia a ABSTRACT: Seasonal variation in the incidence of disease in general, and of infectious diseases in particular, is vitally important information for epidemiologists and for clinicians who deal with these diseases. In relation to communityacquired pneumonia (CAP), the seasonal distribution of the disease and, in particular, of each of the specific aetiological agents is important. All 346 adult patients who were admitted to a regional hospital in southern Israel for CAP over a period of 1 year were included in a prospective study. As part of the study, a comprehensive diagnostic work-up was performed to identify the specific causative agents for CAP. The study findings were analysed and are presented in terms of the seasonal distribution of the disease.Thirty four percent of CAP cases occurred in the spring and only 18% in the autumn (p=0.036). Respiratory viruses CAP were predominant in the winter and spring (p=0.009), whilst Mycoplasma pneumoniae CAP reached its peak incidence of 41% in the spring compared with 15% during the winter months (p=0.054). No significant seasonal predominance was observed for the other specific aetiological agents of CAP. In 58% of the CAP patients who were hospitalized in the autumn we identified a pneumococcal aetiology, whilst this agent was found in only 32% of the cases in the winter.In contrast with popular public opinion, winter with its low temperatures is not the main reason for the development of community-acquired pneumonia. Most of the specific aetiologies for community-acquired pneumonia, with the exception of respiratory viruses and Mycoplasma pneumoniae, have no seasonal predilection.

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“…Infection with this agent is the leading cause of acute pneumonitis in high contact environments such as college campuses and military bases, as well as being a common cause of respiratory illness in children (1). Illnesses associated with M. pneumoniae infections range from mild upper respiratory infection, through tracheobronchitis, to acute pneumonia (2).…”

Section: Introductionmentioning

confidence: 99%

Experimental infection of the respiratory tract with Mycoplasma pneumoniae.

Hu¹,

Kirtz²,

Gardner³

et al. 1980

Environ Health Perspect

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M. pneumoniae, a common human respiratory pathogen, has been studied experimentally for years using intranasal inoculation of the golden Syrian hamster. Because of recent evidence outlining the role in pulmonary immune development of particle size and depth of mycoplasma deposition in the hamster lung, we developed an aerosol chamber for the reproducible aerosolization of radiolabeled M. pneumoniae.Organisms were labeled to high specific activity by the incorporation of 3H-oleic acid and aerosolized under airflow and humidity conditions creating a mean particle diameter of 2.0 ,um. Under these conditions, viable mycoplasmas were reproducibly and evenly distributed to all major lobes of the lung. Examination of radioactive clearance and organism viability within the lung during the first 48 hr after aerosolization have suggested a minimal role for macrophage mycoplasmacidal activity and a more prominent role for ciliary clearance. Data from aerosol infections of hamsters with radio-labeled M. pneumoniae should provide a unique opportunity to examine in a highly controlled manner the effects of air pollutants on the initial stages of infection as well as effects on the development of pulmonary immunity and histologic alterations.

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Mycoplasma pneumoniae Disease: Clinical Spectrum, Pathophysiology, Epidemiology, and Control

Cited by 234 publications

References 55 publications

Ten and a half years seroepidemiology ofMycoplasma pneumoniaeinfection in Denmark

Ten and a half years seroepidemiology ofMycoplasma pneumoniaeinfection in Denmark

Seasonal variation in community-acquired pneumonia

Experimental infection of the respiratory tract with Mycoplasma pneumoniae.

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