Mycoplasma Pneumoniae Induced Rash and Mucositis with Bilateral Otitis Media and Sinusitis

Lofgren, Daniel H; Lenkeit, Christopher; Palanisamy, Jaishree; Brown, Jens

doi:10.7759/cureus.7449

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Existen evidencias que lo relacionan con casos de conjuntivitis y uveítis [ 191, 192], otitis media [ 193 , 194 ], pérdida de audición repentina [ 195 ], y Síndrome de Grisel [ 196 ]. El papel que puede desempeñar M. pneumoniae como agente etiológico de la miringitis bullosa está, en estos momentos, en entredicho [ 197 - 200 ].…”

Section: Especies Implicadas En Patología Humanaunclassified

Clinical implications of the genus Mycoplasma

Rufo¹,

Sánchez²,

Sánchez³

et al. 2021

Rev Esp Quimioter

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Within Mycoplasma genus, M. pneumoniae, M. genitalium, M. hominis or U. urealyticum are the main species that have been traditionally linked to infectious processes. However, there are many other species involved in these conditions and that are, frequently, unfamiliar to healthcare professionals. The aim of this review is to identify all Mycoplasma genus species that have been isolated in human beings and to determine their involvement in infectious pathology.

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Section: Especies Implicadas En Patología Humanaunclassified

Clinical implications of the genus Mycoplasma

Rufo¹,

Sánchez²,

Sánchez³

et al. 2021

Rev Esp Quimioter

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“…Mycoplasma pneumonia (MP) is a common pathogen that gives rise to respiratory infectious diseases such as pediatric pneumonia 1 . MP occurs frequently in preschool children and may induce rhinitis, otitis media, tonsillitis, etc 2 , seriously affecting the physical and mental health of children. 3 Antibacterial agents have been clinically preferred for the treatment of mycoplasma pneumonia, but antibacterial agents alone have not achieved the desired effect.…”

Section: Introductionmentioning

confidence: 99%

Clinical effect of reduning combined with gamma globulin treatment on symptom improvement serum levels of IL-6, 25-(OH)D and LDH in children with severe mycoplasma pneumonia

Ma¹,

Gao²,

2022

Pak J Med Sci

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Objectives: To investigate the effects of Reduning combined with gamma globulin on symptom improvement and serum levels of interleukin-6 (IL-6), 25-hydroxyvitamin D[25-(OH)D] and lactate dehydrogenase (LDH) in children with severe mycoplasma pneumonia (MP). Methods: A total of 123 children with severe MP admitted to the Changzhou Cancer Hospital affiliated to Soochow University from May 2018 to April 2020 were selected as subjects and randomly divided into three groups: control Group-A, control Group-B and the observation group, with 41 cases in each group. Control Group-A was given with Reduning, control Group-B was treated with gamma globulin, while the observation group was treated with Reduning injection combined with gamma globulin. The clinical efficacy, symptom improvement, incidence of adverse reactions, serum levels of IL-6, 25-(OH)D, LDH, Toll-like receptor 4/myeloid differentiation factor 88 (TLR4/MyD88) signaling pathway and T lymphocyte subsets before and after treatment were statistically compared between the three groups. Results: The total effective rate of treatment in the observation group was higher than that in control Group-A and control Group-B (p<0.05); The time for body temperature, lung rales, and cough to return to normal in the observation group was shorter than that in control Group-A and control Group-B (p<0.05). After treatment, the observation group had lower serum levels of IL-6, LDH, and higher levels of 25-(OH)D compared with control Group-A and control Group-B (p<0.05). Moreover, the observation group had lower serum expressions of TLR4 and MyD88 (p<0.05), higher serum levels of CD4+, CD4+/CD8+, and lower CD8+ compared with control Group-A and control Group-B (p<0.05). No significant difference can be seen in the comparison of the incidence of adverse reactions between the three groups (p>0.05). Conclusions: Reduning combined with gamma globulin in the treatment of severe MP is worthy of clinical promotion and application. With such a treatment regimen, the immune function of children with severe MP can be significantly enhanced, the inflammatory response can be suppressed, and symptom improvement can be promoted, further improving the treatment outcome. doi: https://doi.org/10.12669/pjms.38.4.5203 How to cite this:Ma X, Gao W, An J. Clinical effect of reduning combined with gamma globulin treatment on symptom improvement serum levels of IL-6, 25-(OH)D and LDH in children with severe mycoplasma pneumonia. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.5203 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mycoplasma Pneumoniae-Induced Rash and Mucositis: A Systematic Review of the Literature

Lofgren

Lenkeit

2021

Spartan Medical Research Journal

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CONCLUSIONMycoplasma-induced rash and mucositis is a recently described extra-pulmonary manifestation of Mycoplasma pneumoniae infections. To the best of the authors' knowledge, this is the first systematic review of the MIRM literature since the introduction of the diagnosis in 2014. The authors hope that this review can serve to better our current understanding and lead to improved identification, work-up, and treatment of this disease. One notable limitation of this study is the relatively small sample size, which is due to the recent introduction of the term.

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Mycoplasma Pneumoniae Induced Rash and Mucositis with Bilateral Otitis Media and Sinusitis

Cited by 3 publications

References 11 publications

Clinical implications of the genus Mycoplasma

Clinical implications of the genus Mycoplasma

Clinical effect of reduning combined with gamma globulin treatment on symptom improvement serum levels of IL-6, 25-(OH)D and LDH in children with severe mycoplasma pneumonia

Mycoplasma Pneumoniae-Induced Rash and Mucositis: A Systematic Review of the Literature

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