Mycoplasma Pneumoniae–Induced Rash and Mucositis: A Longitudinal Perspective and Proposed Management Criteria

Gise, Ryan; Elhusseiny, Abdelrahman M.; Scelfo, Christina; Mantagos, Iason S.

doi:10.1016/j.ajo.2020.06.010

Cited by 13 publications

(11 citation statements)

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“…The male predominance in the current study is comparable to previously published studies. (13,14) Neither is particularly helpful in distinguishing the two entities. One way to differentiate the two is with clinical and/or radiological signs of atypical pneumonia as well as, more de nitively, with serology.…”

Section: Discussionmentioning

confidence: 99%

“…(19,20) In comparison, ocular ndings in patients with MIRM have been documented in up to 82% of cases. (9,(12)(13)(14) However, this may be an overestimate as there are few reports of MIRM in the literature to date, and a likely bias for reporting the more severe cases. Nonetheless, reports on ocular complications in these patients primarily describe milder symptoms, particularly in younger patients.…”

Section: Discussionmentioning

confidence: 99%

“…The ocular surface is reported to be involved anywhere between 82%-100% in MIRM cases. (9,(12)(13)(14) The most commonly reported ocular ndings include conjunctivitis, blepharitis, subconjunctival hemorrhage, ulceration, and optic disc swelling; ocular signs are typically bilateral. Overall, conjunctivitis is documented as the most common ocular manifestation.…”

Section: Introductionmentioning

confidence: 99%

“…Overall, conjunctivitis is documented as the most common ocular manifestation. (9,(12)(13)(14) Since patients with MIRM initially present with mucositis, SJS/TEN must be considered on the initial differential diagnosis and patients managed accordingly. However, unlike the skin lesions found in SJS/TEN, the lesions in MIRM do not typically progress to con uence, involve a large total body surface area, or show evidence of subsequent necrolysis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute ophthalmic manifestations in Mycoplasma induced rash and mucositis

Rashad¹,

Elhusseiny²,

Shanbhag³

et al. 2022

The Ocular Surface

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute ophthalmic manifestations in Mycoplasma induced rash and mucositis

Rashad¹,

Elhusseiny²,

Shanbhag³

et al. 2022

The Ocular Surface

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“…They reported one patient who developed mild bilateral symblephara and another patient with eyelid margin scarring. (14) Their series did not include adults. In our series, which included 10 adult eyes, no patients underwent AMT or ProKera placement though this alone cannot be used as a marker of severe disease as the threshold for placement may be different between our institutions.…”

Section: Discussionmentioning

confidence: 99%

Acute Ophthalmic Manifestations in Mycoplasma Induced Rash and Mucositis

Rashad

Elhusseiny

Shanbhag

et al. 2021

Preprint

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Background: The purpose of the current study is to demonstrate the prevalence of ocular complications in patients suffering with MIRM, an eruption clinically distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).Methods: In this retrospective observational study, we identified all patients in our hospital database who were diagnosed with MIRM. Diagnosis was confirmed by clinical information and a positive Mycoplasma pneumoniae serology. Only patients with available records with formal ophthalmology consults were included. Clinical and laboratory data were collected from our electronic medical record system.Results: A total of 11 patients were included in our study. The average age was 22 ± 15.2 years, and the majority were male (63.6%). In all 22 eyes, the acute ocular findings were limited to conjunctival hyperemia (n=18, 81.8%), meibomitis (n=2, 9.1%), and conjunctival epithelial defects (n=1, 4.5%). None of the patients were treated with amniotic membrane transplantation in the acute phase. Three patients received follow-up eye examinations; none showed ocular complications.Conclusions: Ocular complications from MIRM appear to be milder in comparison to ocular complications found in other bullous and inflammatory conditions such as SJS/TEN. Understanding the ocular sequelae of MIRM is important to better inform acute and chronic management.

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