Mycoplasma pneumoniae-Induced Rash and Mucositis in a Previously Healthy Man: A Case Report and Brief Review of the Literature

Gandelman, Jocelyn S.; Kim, Elizabeth Y.; Grzegorczyk, Anne M; Zejnullahu, Kreshnik; Edson, Randall S.

doi:10.1093/ofid/ofaa437

Cited by 5 publications

(1 citation statement)

References 31 publications

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“…Most of the cases occurred in older children, as reported previously ( 5 ). Although the age is an important characteristic of MIRM ( 15 ), MIRM can occur over a wide age-range, and has also been reported in adults ( 16 , 17 ). There were 3 cases aged <2 years in our study, and the youngest case was aged only 10 months, which is rare.…”

Section: Discussionmentioning

confidence: 99%

Case Report and Literature Review: Clinical Characteristics of 10 Children With Mycoplasma pneumoniae-Induced Rash and Mucositis

Chen

2022

Front. Pediatr.

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Mycoplasma pneumoniae-induced rash and mucositis (MIRM) is a rare disease, which has not been reported in northern China previously. We retrospectively analyzed the clinical characteristics, diagnosis and treatment of 10 cases of MIRM in order to help clinicians to identify MIRM and to distinguish it from the similar mucositis and cutaneous characteristics of Stevens-Johnson syndrome. All 10 children included in the study had MIRM with skin and mucosal symptoms, but the characteristics of the skin and mucosal lesions differed by age. Most of the older children had sparse erythema and a vesicular rash, but the younger children had dense erythema without blisters but with purulent exudation. The mucositis was relatively mild in the younger children. The erythrocyte sedimentation rate, the levels of C-reactive protein, lactate dehydrogenase, and D-dimer were significantly elevated in most children with MIRM. Concomitant treatment of glucocorticoids and/or IVIG with macrolides may shorten the duration of fever and accelerate the clinical recovery. Additional case reports are needed to improve knowledge of the characteristics of MIRM and its response to therapy.

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Section: Discussionmentioning

confidence: 99%

Case Report and Literature Review: Clinical Characteristics of 10 Children With Mycoplasma pneumoniae-Induced Rash and Mucositis

Chen

2022

Front. Pediatr.

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Update on Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management

Shah,

Parisi,

Mukherjee

et al. 2024

Am J Clin Dermatol

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Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the most severe cutaneous adverse reactions that are typically drug-induced in adults. Both SJS and TEN have high morbidity and mortality rates. SJS/TEN imposes clinical challenges for physicians managing patients suffering from this condition, both because it is rare and because it is a rapidly progressing systemic disease with severe cutaneous, mucosal, and systemic manifestations. Although many cases of SJS/TEN have been reported in the literature, there is no consensus regarding diagnostic criteria or treatment. Significant progress has been made in understanding its genetic predisposition and pathogenesis. This review is intended to provide physicians with a comprehensive but practical SJS/TEN roadmap to guide diagnosis and management. We review data on pathogenesis, reported precipitating factors, presentation, diagnosis, and management SJS/TEN focusing on what is new over the last 5 years.

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