Mycoplasma pneumoniae infection–induced erythema nodosum, anaphylactoid purpura, and acute urticaria in 3 people in a single family

Kano, Yoko; Mitsuyama, Y.; Hirahara, Kazuki; Shiohara, Tetsuo

doi:10.1016/j.jaad.2005.08.027

Cited by 39 publications

(26 citation statements)

References 11 publications

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“…Less commonly, they present with targetoid lesions and nonpitting edema in the context of acute hemorrhagic edema of young children, which is considered the infantile variant of Henoch-Schönlein syndrome, or with urticarial plaques in the context of urticarial vasculitis. Our review disclosed 21 cases of leukocytoclastic vasculitides associated with M. pneumoniae infection: 18 cases of Henoch-Schönlein syndrome, 1 case of acute hemorrhagic edema and 2 cases of urticarial vasculitis [42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62]. …”

Section: Resultsmentioning

confidence: 99%

“…Our review disclosed 11 erythema nodosum cases associated with M. pneumoniae infection [4,54,58,78,79,80,81,82,83]. No more than 1 case of erythema nodosum associated with M. pneumoniae respiratory infection was noted in 9 case series [4,79,84,85,86,87,88,89,90] including a total of 654 erythema nodosum cases not addressing this possible association.…”

Section: Resultsmentioning

confidence: 99%

“…Using the described strategy, 94 reports were retained for the final analysis [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97]: 1 in German [23], 1 in Italian […”

Section: Data Assessmentmentioning

confidence: 99%

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Unusual Eruptions Associated with Mycoplasma pneumoniae Respiratory Infections: Review of the Literature

et al. 2015

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Background: Maculopapular or urticarial eruptions and erythema multiforme sometimes occur in patients affected with Mycoplasma pneumoniae respiratory infections. Further eruptions have also been reported. Objective: To review the literature addressing M. pneumoniae respiratory infection and rather unusual eruptions. Methods: Computer-based search in the US National Library of Medicine database as well as in the search engine Google. Results: We found a possible relationship between M. pneumoniae infection and Fuchs' syndrome (n = 37), varicella-like eruptions (n = 8), Henoch-Schönlein syndrome and further leukocytoclastic vasculitides (n = 21) and erythema nodosum (n = 11). A temporal relationship was also observed with 2 cases of Gianotti-Crosti syndrome. Finally, there exists reasonable evidence that pityriasis rosea Gibert and pityriasis lichenoides et varioliformis acuta Mucha-Habermann are not associated with Mycoplasma infections. Conclusion: This review implies that M. pneumoniae may cause, in addition to erythematous maculopapular (or urticarial) eruptions and erythema multiforme, Fuchs' syndrome and varicella-like eruptions. Furthermore, there is an intriguing link with leukocytoclastic vasculitides or erythema nodosum that deserves further investigation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Data Assessmentmentioning

confidence: 99%

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Unusual Eruptions Associated with Mycoplasma pneumoniae Respiratory Infections: Review of the Literature

et al. 2015

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“…This systemic disorder of the capillary vessels is not restricted to the skin; rather it also leads to microvascular bleeding manifesting as arthropathy (pain, swelling), gastrointestinal symptoms (severe abdominal pain, intestinal bleeding), and renal involvement (hematuria, nephritis) etc. It is possible that several infections can elicit these allergic reactions, and M. pneumoniae-infection-associated anaphylactoid purpura has sporadically been reported [Ghosh & Clements, 1992;Kano et al, 2007]. Considering the immunomodulatory properties of M. pneumoniae, it is reasonable to assume that M. pneumoniae can cause anaphylactoid purpura.…”

Section: Dermatological System 321 Anaphylactoid Purpuramentioning

confidence: 99%

Mycoplasma pneumoniae as an Under- Recognized Agent of Vasculitic Disorders

Narita¹

2011

Advances in the Etiology, Pathogenesis and Pathology of Vasculitis

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“…The indirect type involves the host response to antigens on the microbes 12) . Investigators have speculated that host immune responses, including immune complexmediated injury and cytotoxic T cellmediated responses, play an important role 12) . It is .…”

Section: Case Reportmentioning

confidence: 99%

A Case of Erythema Nodosum Associated withMycoplasma pneumoniaeInfection: Pathologic Findings and a Presumed Pathogenesis

Kim

Choi

2016

Pediatr Infect Vaccine

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Erythema nodosum (EN) is a painful skin disease characterized by erythematous tender nodules located predominantly over the extensor aspects of the legs. Various etiological factors, including infection, drug administration, and systemic illness have been implicated as causes of EN. Mycoplasma pneumoniae is one of rare infectious agents to cause EN in children. We report a case of a 7-year-old boy with context of respiratory illness and skin lesions with arthralgia. From stepwise approaches, IgM antibody against M. pneumoniae was positive with titers of 12.18, consistent with respiratory infection of M. pneumoniae and histopathology showed findings of septal and lobular inflammation without vasculitis consistent with EN. In addition, we reviewed the pathogenesis of this disease based on our case and the previous reports.

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Mycoplasma pneumoniae infection–induced erythema nodosum, anaphylactoid purpura, and acute urticaria in 3 people in a single family

Cited by 39 publications

References 11 publications

Unusual Eruptions Associated with <b><i>Mycoplasma pneumoniae</i></b> Respiratory Infections: Review of the Literature

Unusual Eruptions Associated with <b><i>Mycoplasma pneumoniae</i></b> Respiratory Infections: Review of the Literature

Mycoplasma pneumoniae as an Under- Recognized Agent of Vasculitic Disorders

A Case of Erythema Nodosum Associated withMycoplasma pneumoniaeInfection: Pathologic Findings and a Presumed Pathogenesis

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