Mycoremediation of pretilachlor and its metabolite by <i>Aspergillus ficuum</i>

Kwatra, Nancy; Abraham, Jayanthi

doi:10.1080/03601234.2023.2232276

Journal of Environmental Science and Health, Part B

2023

DOI: 10.1080/03601234.2023.2232276

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Mycoremediation of pretilachlor and its metabolite by Aspergillus ficuum

Nancy Kwatra

Jayanthi Abraham

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2024

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Toxicity and Glutathione S-Transferase-Catalyzed Metabolism of R-/S-Metolachlor in Rice

Wei,

Chen,

Zhang

et al. 2024

J. Agric. Food Chem.

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Metolachlor, the chiral herbicide, inhibits the very-long-chain fatty acid (VLCFA) synthesis; elucidating the enantioselectivity between R-and S-metolachlor in the toxicological difference will facilitate the understanding of the site of action. We found that the endogenous accumulation of C22 VLCFAs decreased in both R-/S-metolachlor -treated plants by 6, 12, and 24 h after treatment, with more significant reduction in the S isomer group. Gene expression of glutathione S-transferase OsGST Tau members were obviously induced upon treatments with S or R isomer; both OsGSTU1 and OsGSTU4 can metabolize metolachlor effectively, with S isomer as the preference by directly catalyzing the conjugation between S-metolachlor and glutathione. In the current study, we provide the first evidence in rice seedlings that S-metolachlor showed herbicidal toxicity by blocking the synthesis of C22-type fatty acid, which eventually affects the whole elongation chain of (V)LCFA. Meanwhile, OsGSTU1 and 4 metabolize the metolachlor with the S isomer as preference. All of these discoveries broaden our knowledge about metolachlor toxicology and enantioselectivity.

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Toxicity and Glutathione S-Transferase-Catalyzed Metabolism of R-/S-Metolachlor in Rice

Wei,

Chen,

Zhang

et al. 2024

J. Agric. Food Chem.

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show abstract

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Mycoremediation of pretilachlor and its metabolite by Aspergillus ficuum

Cited by 1 publication

References 32 publications

Toxicity and Glutathione S-Transferase-Catalyzed Metabolism of R-/S-Metolachlor in Rice

Toxicity and Glutathione S-Transferase-Catalyzed Metabolism of R-/S-Metolachlor in Rice

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