Mycoses and Antifungals: reviewing the basis of a current problem that still is a biotechnological target for marine products

Terra, Luciana; Abreu, Paula Alvarez; Teixeira, Valéria Laneuville; Paixão, Izabel Christina Nunes de Palmer; Pereira, Rebeca; Leal, Bruno; Lourenço, André Luiz; Rampelotto, Pabulo Henrique; Castro, Helena C.

doi:10.3389/fmars.2014.00012

Cited by 10 publications

(9 citation statements)

References 123 publications

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“…Unlike planktonic organisms, cells encased in biofilm matrix exhibit 1000-fold increased resistance to antifungal agents ( Rasmussen and Givskov, 2006 ). Azole groups such as fluconazole, ketoconazole, itraconazole, voriconazole, and posaconazole which target the ergosterol biosynthetic pathway are commonly used for antifungal treatments.3pc Shortly, fluconazole resistant C. albicans, C. glabrata , and C. krusei have been reported in immunocompromised patients ( Cowen et al, 2000 ; Vandeputte et al, 2011 ; Terra et al, 2014 ). Similarly, antifungal resistance in NAC species against caspofungin and amphotericin B in the mixed species milieu as well as in transplant recipients has already been reported ( Schwartz and Patterson, 2018 ; Vipulanandan et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Quinic Acid Derived From Syzygium cumini and Undecanoic Acid Against Candida spp. Biofilm and Virulence

et al. 2018

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In recent decades, fungal infections have incredibly increased with Candida genus as the major cause of morbidity and mortality in hospitalized and immunocompromised patients. Most of the Candida species are proficient in biofilm formation on implanted medical devices as well as human tissues. Biofilm related Candida infections are very difficult to treat using common antifungal agents owing to their increased drug resistance. To address these issues, the present study investigated the antibiofilm and antivirulent properties of Syzygium cumini derived quinic acid in combination with known antifungal compound undecanoic acid. Initially, antibiofilm potential of S. cumini leaf extract was assessed and the active principles were identified through gas chromatography and mass spectrometry analysis. Among the compounds identified, quinic acid was one of the major compounds. The interaction between quinic acid and undecanoic acid was found to be synergistic in the Fractional inhibitory concentration index (≤0.5). Results of in vitro assays and gene expression analysis suggested that the synergistic combinations of quinic acid and undecanoic acid significantly inhibited virulence traits of Candida spp. such as the biofilm formation, yeast-to-hyphal transition, extracellular polymeric substances production, filamentation, secreted hydrolases production and ergosterol biosynthesis. In addition, result of in vivo studies using Caenorhabditis elegans demonstrated the non-toxic nature of QA-UDA combination and antivirulence effect against Candida spp. For the first time, synergistic antivirulence ability of quinic acid and undecanoic acid was explored against Candida spp. Thus, results obtained from the present study suggest that combination of phytochemicals might be used an alternate therapeutic strategy for the prevention and treatment of biofilm associated Candida infection.

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Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Quinic Acid Derived From Syzygium cumini and Undecanoic Acid Against Candida spp. Biofilm and Virulence

et al. 2018

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“…Antifungal resistance is the major concern in the management of invasive candidiasis and also prime cause of treatment failure in the patients . Drug resistance in C. albicans and NCAC species against azoles, echinocandins, amphotericin B and flucytosine has already been reported . The urgent need to overcome the current situation is to go for anti‐infectives against Candida infections which can target biofilm formation and drug resistance without any selection pressure on growth of the pathogen.…”

Section: Introductionmentioning

confidence: 99%

Green synthesized silver nanoparticles demonstrating enhanced in vitro and in vivo antibiofilm activity against Candida spp.

et al. 2018

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Candida species are opportunistic fungal pathogens, which are known for their biofilm associated infections on implanted medical devices in clinical settings. Broad spectrum usage of azole groups and other antifungal agents leads to the occurrence of drug resistance among Candida species. Most of the antifungal agents have failed to treat the biofilm mediated Candida infections. In the present study, silver nanoparticles (AgNPs) were synthesized using Dodonaea viscosa and Hyptis suoveolens methanolic leaf extracts and characterized by ultraviolet-visible absorption spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy and Scanning electron microscopy, Dynamic light scattering, and Zeta potential analysis. The main goal of this study was to assess the AgNPs for their antibiofilm efficacy against Candida spp. through microscopic analysis and in vitro virulence assays. The results revealed that AgNPs strongly inhibited more than 80% biofilm formed by Candida spp. Furthermore, the AgNPs also reduced the yeast-to-hyphal transition, exopolysaccharide biosynthesis, secreted aspartyl proteinase production which are the major virulence factors of Candida species. This study reveals that biosynthesized AgNPs can be considered for the treatment of biofilm related Candida infections.

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“…A good enhancer of pimaricin ( 58 ) in S. natalensis , named PI factor, 2,3-diamino-2,3-bis(hydroxymethyl)-1,4-butanediol, has been detected from S. natalensis , and was found to exert its eliciting action at very low concentrations [ 87 ]. Pimaricin is a glycosylated polyene, with powerful and promising antiviral, antibacterial and antifungal potencies [ 88 ].…”

Section: Specific Chemical Elicitorsmentioning

confidence: 99%

A Glossary for Chemical Approaches towards Unlocking the Trove of Metabolic Treasures in Actinomycetes

et al. 2021

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Actinobacterial natural products showed a critical basis for the discovery of new antibiotics as well as other lead secondary metabolites. Varied environmental and physiological signals touch the antibiotic machinery that faced a serious decline in the last decades. The reason was exposed by genomic sequencing data, which revealed that Actinomycetes harbor a large portion of silent biosynthetic gene clusters in their genomes that encrypt for secondary metabolites. These gene clusters are linked with a great reservoir of yet unknown molecules, and arranging them is considered a major challenge for biotechnology approaches. In the present paper, we discuss the recent strategies that have been taken to augment the yield of secondary metabolites via awakening these cryptic genes in Actinomycetes with emphasis on chemical signaling molecules used to induce the antibiotics biosynthesis. The rationale, types, applications and mechanisms are discussed in detail, to reveal the productive path for the unearthing of new metabolites, covering the literature until the end of 2020.

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Mycoses and Antifungals: reviewing the basis of a current problem that still is a biotechnological target for marine products

Cited by 10 publications

References 123 publications

Synergistic Effect of Quinic Acid Derived From Syzygium cumini and Undecanoic Acid Against Candida spp. Biofilm and Virulence

Synergistic Effect of Quinic Acid Derived From Syzygium cumini and Undecanoic Acid Against Candida spp. Biofilm and Virulence

Green synthesized silver nanoparticles demonstrating enhanced in vitro and in vivo antibiofilm activity against Candida spp.

A Glossary for Chemical Approaches towards Unlocking the Trove of Metabolic Treasures in Actinomycetes

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