Mycosilver Nanoparticles: Synthesis, Characterization and its Efficacy against Plant Pathogenic Fungi

Akther, Tahira; Hemalatha, S.

doi:10.1007/s12668-019-0607-y

Cited by 68 publications

(19 citation statements)

References 30 publications

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“…The solution was boiled for 1 minute in the microwave and incubated for 10 minutes at 1000 rpm at 25 °C. The supernatant was filtered through Whatmann No:1 filter paper, and was concentrated to a final volume of 5 mL 59,60 .…”

Section: Discussionmentioning

confidence: 99%

High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study

Mittal

Camarillo

Varadarajan

et al. 2020

Sci Rep

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Triple negative breast cancer (TNBC) represents 15-20% of the over one million new breast cancer cases occurring each year. TNBC is an aggressive cancer phenotype, with low 5-year survival rates, high 3-year recurrence rates, and increased risk of metastasis. A lack of three commonly exploited hormone receptors renders tnBc resistant to endocrine therapies and lends to its critical absence of viable therapeutic targets. This necessitates the development of alternate and effective novel therapeutic strategies for tnBc. towards this, our current work seeks to develop the technique of electrical pulse (ep)-mediated turmeric silver nanoparticles (turnp) therapy, known as electrochemotherapy (ect), to effectively target TNBC cells. This technique involves the efficient delivery of natural bioactive molecules with anti-cancer effects via a biophysical means. In these experiments, the bioactive molecules are turmeric, a dried rhizome of Curcuma longa that has been used for centuries, both as a dietary supplement and as a medicine in Ayurveda (science of life) in the indian subcontinent and in traditional Chinese medicine. Our results reveal the combined effect of TurNP + ep treatment in reducing MDA-MB-231 cell viability to as low as 9% at 12 h. Showing biological selectivity, this combination treatment has a substantially lower effect on non-tumorigenic mammary epithelial MCF10A cells (67% viability). To gain mechanistic insights into the actions of TurNP-based ECT treatment, we performed high-throughput, label-free quantitative proteomics studies. proteomics results indicate that turnp + EP treatment significantly influenced expression of a diverse list of proteins, including receptors, transcription factors, structural proteins, kinases, and metabolic enzymes. This include the downregulation of 25 proteins in PI3K-Akt signaling pathway (such as GRB2, EGFR, EPHA2, GNB1, GNB2, 14-3-3 family, and Integrin family proteins), and 12 proteins (AKR1A1,

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Section: Discussionmentioning

confidence: 99%

High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study

Mittal

Camarillo

Varadarajan

et al. 2020

Sci Rep

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“…By altering the membrane permeability, the CANCs can easily enters the cell, disturbs the normal metabolism, and damages the cell organelles. Previous studies showed that silver nanoparticles damage the cell membrane, reduce the enzyme activity and affect the replication, transcription and translation process (Shunyu et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…UV–visible spectroscopy was used for confirming the synthesis of CANCs, by scanning between the range of 200–800 nm. The footprint of functional groups present in the synthesized nanoparticles were analysed through FT-IR spectroscopy, where both the aqueous extracts and CANCs are used and scanned between the range 4000–400 cm − 1 (Perkin Elmer Spectrum100) (Akther et al 2019 ). The synthesised CANCs was analysed through particle size analyzer (Malvern Instruments Ltd), to calculate the average diameter of CANCs based on the random movement of particles present in the colloidal solution.…”

Section: Methodsmentioning

confidence: 99%

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Multi potent aromatic nano colloid: synthesis, characterization and applications

et al. 2020

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In this study the aromatic nanocolloids (CANCs) are synthesized using the noble metal silver by using Citronella extract and confirmed through physio chemical analysis. The synthesised CANCs were evaluated for its antimicrobial activity and antibiofilm activity against pathogenic biofilm forming E. coli. In addition, synthesized CANCs were evaluated for the expression of virulent genes encoding AmpC and CTX-M-15. The results confirmed that CANCs showed effective antimicrobial activity through its bacteriostatic, bactericidal and quorum quencher activity and downregulated CTX-M-15 gene. CANCs were validated as alternate to the commercial fungicides to control plant pathogenic fungi such as A. niger MTCC (281), Fusarium graminearum MTCC (2089) and F. udum MTCC (2204). Furthermore, analysis of CANCs on breast cancer (MCF-7) cells under in vitro condition showed that the cytotoxicity of CANCs is dose dependent. Thus, the multifunctional CANCs can be utilized as potential antimicrobial, antifungal and anticancer agent.

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“…On the contrary, biologically synthesised silver nanoparticles are biocompatible with the living system and do not illicit any fatal immune response due to the presence of bioactive group acting as reducers and capping agents. 14 Since these silver nanoparticles are majorly used in sunscreen lotions, ointments, toothpastes and cosmetic products as compared to chemically synthesized silver nanoparticles. 15 Green synthesis of silver nanoparticles via plant extracts or microorganisms is rapid and quick.…”

Section: Introductionmentioning

confidence: 99%

Brief review on recent outcomes of applications of green synthesis vs chemical synthesis of silver nanoparticles

Rani¹

2020

IJCAAP

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Silver nanoparticles (AgNP) have been already proposed for many advanced research approaches in the fields of therapeutics and nanomedicine due to their non-antigenicity and more potent optical characteristics along with their respective antioxidant and antimicrobial properties in effective site specific targeted drug-delivery practices systems. In last few years, chemically synthesized metal based nanoparticles has been studies for their biological and delivery behaviours because of use of various chemical and bio-hazardous chemicals in their preparations. Various previous studies on green synthesis of silver metal based nanoparticles have been designed which involved biological sources like microorganisms, plants and herbal extracts as cost effective, eco-friendly and non-toxic approaches. So that, green synthesis of silver nanoparticles has been much exploited in wider range of applications in the field of biomedical, therapeutics, nanomedicine and pharmaceuticals as more potent and safe drug delivery vehicles as compared to chemically preparations of silver nanoparticles. Therefore, in this review, we recollected the comparative studies based on advantages of green approaches of silver nanoparticles over their respective chemical preparations.

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Mycosilver Nanoparticles: Synthesis, Characterization and its Efficacy against Plant Pathogenic Fungi

Cited by 68 publications

References 30 publications

High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study

High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study

Multi potent aromatic nano colloid: synthesis, characterization and applications

Brief review on recent outcomes of applications of green synthesis vs chemical synthesis of silver nanoparticles

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