2014
DOI: 10.1097/dad.0000000000000207
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Mycosis Fungoides

Abstract: Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. Although it was first described in 1833, our understanding of this disease has continued to evolve. From a diagnostic perspective, the diagnosis of MF can be challenging particularly in the early stages of the disease, because of overlap between the histological features of early MF lesions and many other inflammatory dermatoses. Furthermore, there has been an emergence of numerous clinicopathologic and immunohistochemical variants of… Show more

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Cited by 58 publications
(50 citation statements)
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“…Classic histopathologic findings include lymphocytes infiltrating the epidermis (epidermotropism), atypical lymphocytes with cerebriform nuclei [2], small aggregates of atypical lymphocytes in association with Langerhans cells (Pautrier microabcesses) [2,3], and increasing size of lymphocytes as they migrate towards the granular layer of the epidermis [2]. Pautrier microabscesses are seen in less than a quarter of patients with early MF and atypical lymphocytes are seen in less than 10% [4].…”
Section: Discussionmentioning
confidence: 99%
“…Classic histopathologic findings include lymphocytes infiltrating the epidermis (epidermotropism), atypical lymphocytes with cerebriform nuclei [2], small aggregates of atypical lymphocytes in association with Langerhans cells (Pautrier microabcesses) [2,3], and increasing size of lymphocytes as they migrate towards the granular layer of the epidermis [2]. Pautrier microabscesses are seen in less than a quarter of patients with early MF and atypical lymphocytes are seen in less than 10% [4].…”
Section: Discussionmentioning
confidence: 99%
“…Mycosis fungoides (MF) is the most common primary form of cutaneous lymphoma (Ahn et al, 2014) and accounts for almost 50% of all these types of lymphoma (Doukaki et al, 2009, Whittaker and Foss, 2007). MF affects most commonly middle-aged and elderly adults of all races Hwang et al, 2008, Scarisbrick, 2006) who usually present with persistent and/or slowly progressive skin lesions of varying sizes and shapes (Fatemi Naeini et al, 2015, Jang et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Although MF was first described in 1833 (Ahn et al, 2014) and our understanding of this disease continues to evolve, MF remains a significant diagnostic challenge (Arps et al, 2014, Diwan, 2016, Nashan et al, 2007, Ngan et al, 2014, Oschlies and Klapper, 2013) because it can have different diagnoses on the basis of clinical and histological test results, especially at the early stage of the infection (i.e., mainly inflammatory dermatoses). Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon.…”
Section: Introductionmentioning
confidence: 99%
“…It is a malignant, insidious, cutaneous, extranodal non-Hodgkin's lymphoma (NHL) [1]. MF encompasses about 4% of all lymphoma cases worldwide and has an incidence of 0.36 per 100,00 [2].…”
Section: Introductionmentioning
confidence: 99%
“…MF encompasses about 4% of all lymphoma cases worldwide and has an incidence of 0.36 per 100,00 [2]. The MF disease process has a relatively predictable pattern: in three phases, erythematous or eczematous patches can become infiltrated plaques and cutaneous tumors [1]. Extracutaneous manifestations of MF can involve a wide array of sites, particularly lymph nodes [3].…”
Section: Introductionmentioning
confidence: 99%