Mycosis fungoides: An important differential diagnosis for acquired palmoplantar keratoderma

Abstract

Mycosis fungoides is the most common subtype of primary cutaneous lymphoma and has several clinical variants. We report a 74-year-old man presenting with an acquired palmoplantar keratoderma initially diagnosed and treated as psoriasis with suboptimal improvement. Several months later the patient developed patches and plaques that were histologically consistent with mycosis fungoides. These lesions were ameliorated with the treatment of the underlying mycosis fungoides and the palmoplantar keratoderma resolved promptly with radiotherapy. This case highlights the importance of considering mycosis fungoides as an infrequent but serious cause of acquired palmoplantar keratoderma.

Case of mycosis fungoides palmaris et plantaris possibly associated with nail psoriasis

“…3 Some reports have also described MFPP progressing from psoriasis or lichen planus. 4,5 In our case, improvement of the nail deformity following secukinumab indicated the presence of nail psoriasis. However, we were unable to confirm an association between nail psoriasis and MFPP because of the lack of nail biopsy.…”

A case of cutaneous T-cell lymphoma, masquerading as psoriasis, was given etanercept and secukinumab: Emphasizing the need for biopsy confirmation before starting biologics

“…CTCL can mimic psoriasis in different stages as it may produce psoriasiform plaques[ 1 ] or acquired palmoplantar keratoderma[ 2 ] and erythroderma. [ 3 ] Moreover, even histopathologically, early CTCL may be difficult to be differentiated from psoriasiform dermatitis.…”