Mycosis fungoides associated with B-cell malignancies

Abstract

This case series indicates that while the coexistence of Hodgkin's lymphoma and mycosis fungoides is extremely rare, the association of mycosis fungoides and B-cell malignancies is not as rare as reflected in the literature, with non-Hodgkin's lymphoma constituting the most common associated B-cell malignancy. In this series as well as in the cases reported in the literature mycosis fungoides usually preceded the development of B-cell malignancies, which may be in accordance with previous reports of an increased risk of developing a second haematological neoplasm. The importance of a competent immune system for patients with mycosis fungoides is well demonstrated in these cases. It is suggested that for greater precision the criteria for diagnosis of composite lymphoma of the skin should include both phenotypic and genotypic features.

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

“…The coexistence of cutaneous T-cell leukemia (CTCL) with various B-cell lymphoproliferative disorders has been recently reviewed by Barzilai et al [17]. Of the 47 cases reported to that time, 18 (38%) had CLL, and we have summarized the clinical features of these cases plus 8 additional cases in table 1[13,14,15,16,18,19,20,21,22,23,24,25,26,27,28,29,30,31].…”

Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man

“…Narrowing the results, we were able to find 5 cases of hairy cell leukemia along with mycosis fungoides reported [2, 5]. However, the possibility that both T- and B-cell malignancies occurring unrelated to one another in one patient is unlikely, as the incidence of each cutaneous and systemic neoplasm separately is very low [4, 6]. Therefore, the development of cutaneous T-cell lymphoma and hairy cell leukemia is a very rare phenomenon.…”

“…A thorough review of the literature on PubMed, using the search terms (“mycosis fungoides” OR “cutaneous T-cell lymphoma”) AND (leukemia OR leukaemia OR lymphoma OR “lymphoid malignancy” OR “Hodgkin's disease” OR “non-Hodgkin's disease” OR “multiple myeloma” OR “B-cell”), identified 68 cases of concomitant mycosis fungoides and a lymphoid malignancy [2, 4, 5, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27]. Narrowing the results, we were able to find 5 cases of hairy cell leukemia along with mycosis fungoides reported [2, 5].…”

Cutaneous Borreliosis With a T-Cell–Rich Infiltrate and Simultaneous Involvement by B-Cell Chronic Lymphocytic Leukemia With t(14;18)(q32;q21)

“…[13][14][15][16][17][18] Additionally, an association of B-CLL and various cutaneous T-cell lymphomas has been documented, including MF, Sézary syndrome, peripheral T-cell lymphoma involving the skin, and natural killer-cell lymphoma. [19][20][21] Occurrence of leukemic infiltrates on the site of a previous herpes simplex or herpes zoster infection leads to the speculation that specific skin infiltrates of B-CLL can be triggered by antigenic stimulation. [2][3][4][5]22 We are aware of 2 previously published articles documenting the association of specific B-CLL infiltrates and B. burgdorferi infection.…”