Mycosis fungoides: association of <scp>KIR</scp> ligands and <scp>HLA</scp>‐<scp>DQB</scp>1*05 with bad prognosis of the disease

Brazzelli, Valeria; Rivetti, Nicolò; Badulli, C.; Carugno, Andrea; Cananzi, Raffaello; Silvestri, Annalisa De; Martinetti, Miryam; Borroni, G.

doi:10.1111/jdv.13083

Cited by 7 publications

(9 citation statements)

References 14 publications

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“…[1] Study by Brazzelli et al indicated that the susceptibility of MF progression and prognosis depends on specific HLA alleles. [2,3] In vitro study showed that TOX promotes the proliferation of malignant cells in MF. [4] There were also other evidences showing different gene expression between early MF variants and that of late stage.…”

Section: Introductionmentioning

confidence: 99%

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SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF‐κB pathway in Mycosis Fungoides

Chen

Zheng

Zhu

et al. 2019

Experimental Dermatology

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Mycosis Fungoides (MF) is the most common subtype of cutaneous T-cell lymphomas (CTCL). Shank-associated RH domain-interacting protein (SHARPIN) participates in the initiation and development of multiple tumors. However, the clinical significance of SHARPIN in MF hasn't been investigated. The c-Jun N-terminal kinases (JNKs) pathway is a member of mitogen-activated protein kinases (MAPKs). Its dysregulation is observed in various tumors including CTCL, whereas the roles of JNKs pathway in MF remain largely unknown, the relationship between SHARPIN and JNKs pathway remains elusive. Herein, we showed that upregulated expression of SHARPIN was related to poor prognosis of MF patients. In vitro experiments found increased SHARPIN expression and activation of JNKs pathway in MF cell line MyLa2059. SHARPIN induced transforming growth factor β activated kinase-1 (TAK1) transcription, which is an upstream kinase of JNKs, NF-κB and p38 pathway, leading to activation of JNKs and NF-κB pathway. SHARPIN also promoted p38 signalling independent of TAK1 expression, by which overexpression of SHARPIN induced cell proliferation, inhibited apoptosis, enhanced migration and invasion of MyLa2059. Our work provided direct evidences for effects of SHARPIN on JNKs and NF-κB pathway, and the contributing roles of JNKs, NF-κB and p38 pathway regulated by SHARPIN in the development of MF.

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Section: Introductionmentioning

confidence: 99%

“…However, advanced stage of MF, especially with lymph nodes and visceral involvement, is associated with poor prognosis . Study by Brazzelli et al indicated that the susceptibility of MF progression and prognosis depends on specific HLA alleles . In vitro study showed that TOX promotes the proliferation of malignant cells in MF .…”

Section: Introductionmentioning

confidence: 99%

SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF‐κB pathway in Mycosis Fungoides

Chen

Zheng

Zhu

et al. 2019

Experimental Dermatology

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“…Our latest data shows that, 47 alleles of the DQB1 locus were identified and DQB1*05 was common with frequency (16.231%) in Chinese volunteers . One study suggested that the presence of the HLA‐DQB1*05 alleles characterizes the patients with the poorest prognosis in Mycosis fungoides …”

Section: Conflict Of Interestmentioning

confidence: 97%

Characterization of the novel HLA‐DQB105:155* allele by sequencing‐based typing

Zhang

Zhou

Xiao

et al. 2017

HLA

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“…Research Programme, IMIM-Hospital del Mar, Barcelona, Spain 14 Laboratori de Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain 15 Departament de Genètica, Microbiologia i Estadística, Universitat de Barcelona, Barcelona, Spain 16 Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain 17 Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain 18 Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain…”

Section: Ack N Owled G M Entsunclassified

High‐throughput RNA sequencing of the T cell receptor alpha and beta chains for simultaneous clonality and biological analyses in Sezary syndrome

Blanco,

López‐Aventín,

Pujol

et al. 2023

Clinical Laboratory Analysis

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BackgroundPrevious investigations pointed out a role for antigen stimulation in Sezary syndrome (SS). High‐throughput sequencing of the T cell receptor (TR) offers several applications beyond diagnostic purposes, including the study of T cell pathogenesis.MethodsWe performed high‐throughput RNA sequencing of the TR alpha (TRA) and beta (TRB) genes focusing on the complementarity‐determining region 3 (CDR3) in 11 SS and one erythrodermic mycosis fungoides (MF) patients. Five psoriasis patients were employed as controls. Peripheral blood CD4+ cells were isolated and RNA sequenced (HiSeq2500). High‐resolution HLA typing was performed in neoplastic patients.ResultsHighly expanded predominant TRA and TRB CDR3 were only found in SS patients (median frequency: 94.4% and 93.7%). No remarkable CDR3 expansions were observed in psoriasis patients (median frequency of predominant TRA and TRB CDR3: 0.87% and 0.69%, p < 0.001 compared to SS). CDR3 almost identical to the predominant were identified within each SS patient and were exponentially correlated with frequencies of the predominant CDR3 (R2 = 0.918, p < 0.001). Forty‐six different CDR3 were shared between SS patients displaying HLA similarities, including predominant TRA and TRB CDR3 in one patient that were found in other three patients. Additionally, 351 antigen matches were detected (Cytomegalovirus, Epstein–Barr, Influenza virus, and self‐antigens), and the predominant CDR3 of two different SS patients matched CDR3 with specificity for Influenza and Epstein–Barr viruses.ConclusionsBesides detecting clonality, these findings shed light on the nature of SS‐related antigens, pointing to RNA sequencing as a useful tool for simultaneous clonality and biological analysis in SS.

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Mycosis fungoides: association of KIR ligands and HLA‐DQB1*05 with bad prognosis of the disease

Abstract: Our observations suggest that the presence of the HLA-DQB1*05 alleles characterizes the patients with the poorest prognosis in MF. In addition, absence of the KIR-ligand epitope HLA-B Bw4 showed a trend of being more prominent in MF patients with the poorest prognosis.

Cited by 7 publications

References 14 publications

SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF‐κB pathway in Mycosis Fungoides

SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF‐κB pathway in Mycosis Fungoides

Characterization of the novel HLA‐DQB105:155* allele by sequencing‐based typing

High‐throughput RNA sequencing of the T cell receptor alpha and beta chains for simultaneous clonality and biological analyses in Sezary syndrome

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Mycosis fungoides: association of KIR ligands and HLA‐DQB1*05 with bad prognosis of the disease

Abstract: Our observations suggest that the presence of the HLA-DQB1*05 alleles characterizes the patients with the poorest prognosis in MF. In addition, absence of the KIR-ligand epitope HLA-B Bw4 showed a trend of being more prominent in MF patients with the poorest prognosis.

Cited by 7 publications

References 14 publications

SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF‐κB pathway in Mycosis Fungoides

SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF‐κB pathway in Mycosis Fungoides

Characterization of the novel HLA‐DQB1*05:155 allele by sequencing‐based typing

High‐throughput RNA sequencing of the T cell receptor alpha and beta chains for simultaneous clonality and biological analyses in Sezary syndrome

Contact Info

Product

Resources

About

Characterization of the novel HLA‐DQB105:155* allele by sequencing‐based typing