Mycosis Fungoides

Mycosis fungoides—clinical and histopathologic features, differential diagnosis, and treatment

“…ycosis fungoides (MF) is the most common type of cutaneous lymphoma, representing almost 50% of all lymphomas arising primarily in the skin. [1][2][3] It is defined as an epidermotropic, primary cutaneous T-cell lymphoma (CTCL) composed of small-to medium-sized T lymphocytes with cerebriform nuclei and with a T-helper phenotype (but cytotoxic variants are not uncommon). The term MF should be used only for the classical presentation of the disease characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course.…”

“…It is estimated that over 90% of patients with early MF do not progress to tumor stage and do not show extracutaneous manifestations of the disease in their lifetime. [1][2][3]7 Clinical features Clinically, MF presents with patches, plaques, or tumors or a combination of them. 1 Although patches are considered a clinical feature of early MF, it should be underlined that they are frequently seen admixed with plaques and tumors in patients with advanced disease and that patients with advanced MF who are in complete remission may relapse with patches, plaques, or tumors.…”

“…[1][2][3]7 Clinical features Clinically, MF presents with patches, plaques, or tumors or a combination of them. 1 Although patches are considered a clinical feature of early MF, it should be underlined that they are frequently seen admixed with plaques and tumors in patients with advanced disease and that patients with advanced MF who are in complete remission may relapse with patches, plaques, or tumors. Patches of MF are characterized by generalized or localized, variably large, erythematous lesions with a predilection for sun-protected areas, particularly the buttocks and the breast in women (Figures 1 and 2).…”